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- W4311584611 abstract "For nearly 2000 years, Eucommia ulmoides Oliver (EUO) has been utilized in traditional Chinese medicine (TCM) throughout China. Flavonoids present in bark and leaves of EUO are responsible for their antioxidant, anti-inflammatory, antitumor, anti-osteoporosis, hypoglycemic, hypolipidemic, antibacterial, and antiviral properties, but the main bioactive compound has not been established yet. In this study, we isolated and identified quercetin glycoside (QAG) from EUO leaves (EUOL) and preliminarily explored its molecular mechanism in improving insulin resistance (IR). The results showed that QAG increased uptake of glucose as well as glycogen production in the palmitic acid (PA)-induced HepG2 cells in a dose-dependent way. Further, we observed that QAG increases glucose transporters 2 and 4 (GLUT2 and GLUT4) expression and suppresses the phosphorylation of insulin receptor substrate (IRS)-1 at serine612, thus promoting the expression of phosphatidylinositol-3-kinase (PI3K) at tyrosine458 and tyrosine199, as well as protein kinase B (Akt) and glycogen synthase kinase (GSK)-3β at serine473 and serine9, respectively. The influence posed by QAG on the improvement of uptake of glucose was significantly inhibited by LY294002, a PI3K inhibitor. In addition, the molecular docking result showed that QAG could bind to insulin receptors. In summary, our data established that QAG improved IR as demonstrated by the increased uptake of glucose and glycogen production through a signaling pathway called IRS-1/PI3K/Akt/GSK-3β." @default.
- W4311584611 created "2022-12-27" @default.
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- W4311584611 date "2023-02-01" @default.
- W4311584611 modified "2023-10-18" @default.
- W4311584611 title "Quercetin-3-<i>O</i>-α-L-arabinopyranosyl-(1→2)-β-D-glucopyranoside Isolated from <i>Eucommia ulmoides</i> Leaf Relieves Insulin Resistance in HepG2 Cells <i>via</i> the IRS-1/PI3K/Akt/GSK-3β Pathway" @default.
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- W4311584611 doi "https://doi.org/10.1248/bpb.b22-00597" @default.
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