FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311587722> ?p ?o ?g. }

• W4311587722 abstract "The protective arm of the renin-angiotensin system (RAS), the ACE 2/Ang-(1-7)/MasR axis, has become a new anti-inflammatory target. As a specific activator of ACE2, diminazene aceturate (DA) can promote anti-inflammatory effects by regulating the ACE2/Ang-(1-7)/MasR axis. However, due to the reported toxicity of DA, its application has been limited. In the current study, we synthesized a low toxicity DA derivative 3 (DAD3) and sought to determine whether DAD3 can also activate ACE2 in bovine mammary epithelial cells (BMEC) and regulate the RAS system to inhibit inflammation. We found that both DA and DAD3 can activate and promote ACE2 expression in BMEC. iRNA-mediated knockdown of ACE2 demonstrated that DAD3 activates the ACE2/Ang-(1-7)/MasR axis and plays an anti-inflammatory role in BMEC. Furthermore, the inhibitory effects of DA and DAD3 on the protein phosphorylation of MAPK and NF-κB pathways were reduced in ACE2-silenced BMEC. Our findings show that ACE2 is a target of DAD3, which leads to inhibition of the MAPK and NF-κB signalling pathways and protects against LPS-induced inflammation in BMEC. Thus, DAD3 may provide a new strategy to treat dairy cow mastitis." @default.
• W4311587722 created "2022-12-27" @default.
• W4311587722 creator A5009427324 @default.
• W4311587722 creator A5045155728 @default.
• W4311587722 creator A5073983425 @default.
• W4311587722 creator A5079684828 @default.
• W4311587722 creator A5079842059 @default.
• W4311587722 date "2022-12-08" @default.
• W4311587722 modified "2023-09-26" @default.
• W4311587722 title "DAD3 targets ACE2 to inhibit the MAPK and NF-κB signalling pathways and protect against LPS-induced inflammation in bovine mammary epithelial cells" @default.
• W4311587722 cites W1621802391 @default.
• W4311587722 cites W1967561584 @default.
• W4311587722 cites W1981298734 @default.
• W4311587722 cites W1993643603 @default.
• W4311587722 cites W1995373430 @default.
• W4311587722 cites W1997978122 @default.
• W4311587722 cites W2002133040 @default.
• W4311587722 cites W2007146260 @default.
• W4311587722 cites W2014420892 @default.
• W4311587722 cites W2021345753 @default.
• W4311587722 cites W2023168569 @default.
• W4311587722 cites W2028439883 @default.
• W4311587722 cites W2049832267 @default.
• W4311587722 cites W2054052958 @default.
• W4311587722 cites W2054099227 @default.
• W4311587722 cites W2060898700 @default.
• W4311587722 cites W2062199692 @default.
• W4311587722 cites W2064547101 @default.
• W4311587722 cites W2065697164 @default.
• W4311587722 cites W2088845292 @default.
• W4311587722 cites W2096069659 @default.
• W4311587722 cites W2129366803 @default.
• W4311587722 cites W2140325630 @default.
• W4311587722 cites W2156240908 @default.
• W4311587722 cites W2161399617 @default.
• W4311587722 cites W2253391583 @default.
• W4311587722 cites W2256593161 @default.
• W4311587722 cites W249128934 @default.
• W4311587722 cites W2516694377 @default.
• W4311587722 cites W2765704984 @default.
• W4311587722 cites W2768212934 @default.
• W4311587722 cites W2901027024 @default.
• W4311587722 cites W2957650199 @default.
• W4311587722 cites W2999709805 @default.
• W4311587722 cites W3159063715 @default.
• W4311587722 doi "https://doi.org/10.1186/s13567-022-01122-0" @default.
• W4311587722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36482404" @default.
• W4311587722 hasPublicationYear "2022" @default.
• W4311587722 type Work @default.
• W4311587722 citedByCount "1" @default.
• W4311587722 countsByYear W43115877222023 @default.
• W4311587722 crossrefType "journal-article" @default.
• W4311587722 hasAuthorship W4311587722A5009427324 @default.
• W4311587722 hasAuthorship W4311587722A5045155728 @default.
• W4311587722 hasAuthorship W4311587722A5073983425 @default.
• W4311587722 hasAuthorship W4311587722A5079684828 @default.
• W4311587722 hasAuthorship W4311587722A5079842059 @default.
• W4311587722 hasBestOaLocation W43115877221 @default.
• W4311587722 hasConcept C11960822 @default.
• W4311587722 hasConcept C170493617 @default.
• W4311587722 hasConcept C173396325 @default.
• W4311587722 hasConcept C185592680 @default.
• W4311587722 hasConcept C190283241 @default.
• W4311587722 hasConcept C203014093 @default.
• W4311587722 hasConcept C2776914184 @default.
• W4311587722 hasConcept C2777730290 @default.
• W4311587722 hasConcept C502942594 @default.
• W4311587722 hasConcept C55493867 @default.
• W4311587722 hasConcept C57074206 @default.
• W4311587722 hasConcept C62478195 @default.
• W4311587722 hasConcept C86803240 @default.
• W4311587722 hasConcept C88045685 @default.
• W4311587722 hasConcept C95444343 @default.
• W4311587722 hasConcept C98274493 @default.
• W4311587722 hasConceptScore W4311587722C11960822 @default.
• W4311587722 hasConceptScore W4311587722C170493617 @default.
• W4311587722 hasConceptScore W4311587722C173396325 @default.
• W4311587722 hasConceptScore W4311587722C185592680 @default.
• W4311587722 hasConceptScore W4311587722C190283241 @default.
• W4311587722 hasConceptScore W4311587722C203014093 @default.
• W4311587722 hasConceptScore W4311587722C2776914184 @default.
• W4311587722 hasConceptScore W4311587722C2777730290 @default.
• W4311587722 hasConceptScore W4311587722C502942594 @default.
• W4311587722 hasConceptScore W4311587722C55493867 @default.
• W4311587722 hasConceptScore W4311587722C57074206 @default.
• W4311587722 hasConceptScore W4311587722C62478195 @default.
• W4311587722 hasConceptScore W4311587722C86803240 @default.
• W4311587722 hasConceptScore W4311587722C88045685 @default.
• W4311587722 hasConceptScore W4311587722C95444343 @default.
• W4311587722 hasConceptScore W4311587722C98274493 @default.
• W4311587722 hasFunder F4320322877 @default.
• W4311587722 hasIssue "1" @default.
• W4311587722 hasLocation W43115877221 @default.
• W4311587722 hasLocation W43115877222 @default.
• W4311587722 hasLocation W43115877223 @default.
• W4311587722 hasLocation W43115877224 @default.
• W4311587722 hasOpenAccess W4311587722 @default.
• W4311587722 hasPrimaryLocation W43115877221 @default.
• W4311587722 hasRelatedWork W1978760124 @default.
• W4311587722 hasRelatedWork W2004726042 @default.

• next