FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311588651> ?p ?o ?g. }

• W4311588651 abstract "Abstract Background Polycystic ovary syndrome is associated with an increased rate of spontaneous abortion/early pregnancy loss and pups delivered to PCOS animals were abnormal. Currently, assisted reproductive technology has been used to help numerous infertile couples to have their babies. However, there is a low implantation rate after the transfer of embryos. Till now, it could not be concluded whether the reduced pregnancy rates observed were due to abnormal embryos or endometrial modification. Further, transgenic mouse models have been used to find out the molecular deficits behind early pregnancy complications. But, the deletion of crucial genes could lead to systemic deficiencies/embryonic lethality. Also, pregnancy is a complex process with overlapping expression patterns making it challenging to mimic their stage-specific role. Therefore, the motive of the current study was to investigate the probable molecular cascade to decipher the early pregnancy loss in the letrozole-induced PCOS mouse model. Methods PCOS was induced in mice by oral administration of letrozole daily for 21 days. Following, the pregnancy was established and animals were sacrificed on the day 6th of pregnancy. Animals were assessed for early pregnancy loss, hormonal profile, mRNA expression of steroid receptors ( Ar, Pr, Esr1/2 ), decidualization markers ( Hox10/11a ), adhesion markers ( Itgavb3, Itga4b1 ), matrix metalloproteinases and their endogenous inhibitor ( Mmp2/9, Timp1/2) and key mediators of LIF/STAT pathway ( Lif, Lifr, gp130 , stat3 ) were analyzed in the embryo implanted region of the uterus. Morphological changes in ovaries and implanted regions of the uterus were assessed. Results Mice treated with letrozole demonstrated significant increases in testosterone levels along with a decline in progesterone levels as compared to control animals. PCOS animals also exhibited decreased fertility index and disrupted ovarian and embryo-containing uterus histopathology. Altered gene expression of the steroid receptors and reduced expression of Hox10a , integrins, Mmp9, Timp1/3 , Gp130 & Stat3 was observed in the implanted region of the uterus of PCOS animals. Conclusion Our results reveal that majority of the molecular markers alteration in the establishment of early pregnancy could be due to the aberrant progesterone signaling in the embryonic-uterine tissue of PCOS animals, which further translates into poor fetal outcomes as observed in the current study and in several IVF patients." @default.
• W4311588651 created "2022-12-27" @default.
• W4311588651 creator A5060755347 @default.
• W4311588651 creator A5086350231 @default.
• W4311588651 date "2022-12-07" @default.
• W4311588651 modified "2023-10-02" @default.
• W4311588651 title "Decoding the molecular cascade of embryonic-uterine modulators in pregnancy loss of PCOS mother- an “in vivo” study" @default.
• W4311588651 cites W1936533229 @default.
• W4311588651 cites W1984843817 @default.
• W4311588651 cites W1996578742 @default.
• W4311588651 cites W2006494078 @default.
• W4311588651 cites W2011872875 @default.
• W4311588651 cites W2016676909 @default.
• W4311588651 cites W2031856129 @default.
• W4311588651 cites W2037342776 @default.
• W4311588651 cites W2048852622 @default.
• W4311588651 cites W2048885486 @default.
• W4311588651 cites W2064608831 @default.
• W4311588651 cites W2064758929 @default.
• W4311588651 cites W2072762743 @default.
• W4311588651 cites W2098209538 @default.
• W4311588651 cites W2099578825 @default.
• W4311588651 cites W2108070144 @default.
• W4311588651 cites W2110497419 @default.
• W4311588651 cites W2117243630 @default.
• W4311588651 cites W2130638146 @default.
• W4311588651 cites W2132836193 @default.
• W4311588651 cites W2133638137 @default.
• W4311588651 cites W2133883611 @default.
• W4311588651 cites W2142003876 @default.
• W4311588651 cites W2164576139 @default.
• W4311588651 cites W2166693944 @default.
• W4311588651 cites W2167164284 @default.
• W4311588651 cites W2171308782 @default.
• W4311588651 cites W2173213419 @default.
• W4311588651 cites W2202234957 @default.
• W4311588651 cites W2470829143 @default.
• W4311588651 cites W2606670613 @default.
• W4311588651 cites W2763505512 @default.
• W4311588651 cites W2799658728 @default.
• W4311588651 cites W2900935950 @default.
• W4311588651 cites W2903390416 @default.
• W4311588651 cites W2906107223 @default.
• W4311588651 cites W3023058886 @default.
• W4311588651 cites W3124596163 @default.
• W4311588651 cites W4220783199 @default.
• W4311588651 cites W4238872648 @default.
• W4311588651 cites W4241304794 @default.
• W4311588651 cites W4256214420 @default.
• W4311588651 doi "https://doi.org/10.1186/s12958-022-01041-x" @default.
• W4311588651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36476384" @default.
• W4311588651 hasPublicationYear "2022" @default.
• W4311588651 type Work @default.
• W4311588651 citedByCount "1" @default.
• W4311588651 countsByYear W43115886512023 @default.
• W4311588651 crossrefType "journal-article" @default.
• W4311588651 hasAuthorship W4311588651A5060755347 @default.
• W4311588651 hasAuthorship W4311588651A5086350231 @default.
• W4311588651 hasBestOaLocation W43115886511 @default.
• W4311588651 hasConcept C121608353 @default.
• W4311588651 hasConcept C126322002 @default.
• W4311588651 hasConcept C134018914 @default.
• W4311588651 hasConcept C160099875 @default.
• W4311588651 hasConcept C16685009 @default.
• W4311588651 hasConcept C2777176818 @default.
• W4311588651 hasConcept C2777391703 @default.
• W4311588651 hasConcept C2778316770 @default.
• W4311588651 hasConcept C2778812593 @default.
• W4311588651 hasConcept C2779066055 @default.
• W4311588651 hasConcept C2779234561 @default.
• W4311588651 hasConcept C2779306644 @default.
• W4311588651 hasConcept C2779742232 @default.
• W4311588651 hasConcept C2909731803 @default.
• W4311588651 hasConcept C3018442814 @default.
• W4311588651 hasConcept C46973012 @default.
• W4311588651 hasConcept C530470458 @default.
• W4311588651 hasConcept C54355233 @default.
• W4311588651 hasConcept C71924100 @default.
• W4311588651 hasConcept C86803240 @default.
• W4311588651 hasConceptScore W4311588651C121608353 @default.
• W4311588651 hasConceptScore W4311588651C126322002 @default.
• W4311588651 hasConceptScore W4311588651C134018914 @default.
• W4311588651 hasConceptScore W4311588651C160099875 @default.
• W4311588651 hasConceptScore W4311588651C16685009 @default.
• W4311588651 hasConceptScore W4311588651C2777176818 @default.
• W4311588651 hasConceptScore W4311588651C2777391703 @default.
• W4311588651 hasConceptScore W4311588651C2778316770 @default.
• W4311588651 hasConceptScore W4311588651C2778812593 @default.
• W4311588651 hasConceptScore W4311588651C2779066055 @default.
• W4311588651 hasConceptScore W4311588651C2779234561 @default.
• W4311588651 hasConceptScore W4311588651C2779306644 @default.
• W4311588651 hasConceptScore W4311588651C2779742232 @default.
• W4311588651 hasConceptScore W4311588651C2909731803 @default.
• W4311588651 hasConceptScore W4311588651C3018442814 @default.
• W4311588651 hasConceptScore W4311588651C46973012 @default.
• W4311588651 hasConceptScore W4311588651C530470458 @default.
• W4311588651 hasConceptScore W4311588651C54355233 @default.
• W4311588651 hasConceptScore W4311588651C71924100 @default.
• W4311588651 hasConceptScore W4311588651C86803240 @default.
• W4311588651 hasIssue "1" @default.

• next