Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311590068> ?p ?o ?g. }
- W4311590068 abstract "Cancer recurrence and metastasis are still common causes of postsurgery death in patients with solid tumors, suggesting that additional consolidation therapeutic strategies are necessary. We have previously found that oxaliplatin (OXA) treatment causes further up-regulation of CD155, which is abundantly expressed in tumors for resulting in increased sensitivity of cancer to anti-CD155 therapy. Here, we report O-TPNVs, which are TIGIT-expressing cell membrane and platelet cell membrane fusion nanovesicles (TPNVs) loaded with OXA. Platelet-derived membrane components enable O-TPNVs to target postsurgery wounds and interact with circulating tumor cells (CTCs). OXA directly kills residual tumor cells and CTCs, induces immunogenic cell death, and activates the immune system. TPNVs bind to CD155 on tumor cells, block the CD155/TIGIT pathway, and restore CD8 + T cell activity. In vivo analyses reveal that O-TPNVs achieve synergistic chemotherapeutic and immunotherapeutic effects, effectively inhibiting the recurrence and metastasis of triple-negative breast cancer (4T1) after surgery." @default.
- W4311590068 created "2022-12-27" @default.
- W4311590068 creator A5018056497 @default.
- W4311590068 creator A5025764843 @default.
- W4311590068 creator A5033490134 @default.
- W4311590068 creator A5038617728 @default.
- W4311590068 creator A5045285053 @default.
- W4311590068 creator A5050953693 @default.
- W4311590068 creator A5074626282 @default.
- W4311590068 creator A5090510226 @default.
- W4311590068 date "2022-12-09" @default.
- W4311590068 modified "2023-10-18" @default.
- W4311590068 title "Engineered drug-loaded cellular membrane nanovesicles for efficient treatment of postsurgical cancer recurrence and metastasis" @default.
- W4311590068 cites W1767508090 @default.
- W4311590068 cites W196347017 @default.
- W4311590068 cites W1968519475 @default.
- W4311590068 cites W1974693247 @default.
- W4311590068 cites W2029399624 @default.
- W4311590068 cites W2047902191 @default.
- W4311590068 cites W2054790573 @default.
- W4311590068 cites W2060953438 @default.
- W4311590068 cites W2080232352 @default.
- W4311590068 cites W2099342434 @default.
- W4311590068 cites W2102869104 @default.
- W4311590068 cites W2120426523 @default.
- W4311590068 cites W2134094618 @default.
- W4311590068 cites W2134105940 @default.
- W4311590068 cites W2149169462 @default.
- W4311590068 cites W2190141802 @default.
- W4311590068 cites W2239788766 @default.
- W4311590068 cites W2277313374 @default.
- W4311590068 cites W2403400382 @default.
- W4311590068 cites W2554773181 @default.
- W4311590068 cites W2565834876 @default.
- W4311590068 cites W2581996160 @default.
- W4311590068 cites W2597618526 @default.
- W4311590068 cites W26912359 @default.
- W4311590068 cites W2803997637 @default.
- W4311590068 cites W2885017820 @default.
- W4311590068 cites W2885447533 @default.
- W4311590068 cites W2900583139 @default.
- W4311590068 cites W2902979010 @default.
- W4311590068 cites W2905522695 @default.
- W4311590068 cites W2913798055 @default.
- W4311590068 cites W2914243049 @default.
- W4311590068 cites W2914723294 @default.
- W4311590068 cites W2982245165 @default.
- W4311590068 cites W2999417355 @default.
- W4311590068 cites W3018214848 @default.
- W4311590068 cites W3024043480 @default.
- W4311590068 cites W3030448313 @default.
- W4311590068 cites W3044905371 @default.
- W4311590068 cites W3084404519 @default.
- W4311590068 cites W3091696020 @default.
- W4311590068 cites W3092655545 @default.
- W4311590068 cites W3096521890 @default.
- W4311590068 cites W3137798620 @default.
- W4311590068 cites W3181724709 @default.
- W4311590068 cites W3200213699 @default.
- W4311590068 cites W4200442435 @default.
- W4311590068 cites W4280554695 @default.
- W4311590068 cites W70383152 @default.
- W4311590068 doi "https://doi.org/10.1126/sciadv.add3599" @default.
- W4311590068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36490349" @default.
- W4311590068 hasPublicationYear "2022" @default.
- W4311590068 type Work @default.
- W4311590068 citedByCount "17" @default.
- W4311590068 countsByYear W43115900682023 @default.
- W4311590068 crossrefType "journal-article" @default.
- W4311590068 hasAuthorship W4311590068A5018056497 @default.
- W4311590068 hasAuthorship W4311590068A5025764843 @default.
- W4311590068 hasAuthorship W4311590068A5033490134 @default.
- W4311590068 hasAuthorship W4311590068A5038617728 @default.
- W4311590068 hasAuthorship W4311590068A5045285053 @default.
- W4311590068 hasAuthorship W4311590068A5050953693 @default.
- W4311590068 hasAuthorship W4311590068A5074626282 @default.
- W4311590068 hasAuthorship W4311590068A5090510226 @default.
- W4311590068 hasBestOaLocation W43115900681 @default.
- W4311590068 hasConcept C121608353 @default.
- W4311590068 hasConcept C126322002 @default.
- W4311590068 hasConcept C167672396 @default.
- W4311590068 hasConcept C203014093 @default.
- W4311590068 hasConcept C2777701055 @default.
- W4311590068 hasConcept C2777877232 @default.
- W4311590068 hasConcept C2779013556 @default.
- W4311590068 hasConcept C2779118045 @default.
- W4311590068 hasConcept C502942594 @default.
- W4311590068 hasConcept C71924100 @default.
- W4311590068 hasConcept C8891405 @default.
- W4311590068 hasConcept C96232424 @default.
- W4311590068 hasConceptScore W4311590068C121608353 @default.
- W4311590068 hasConceptScore W4311590068C126322002 @default.
- W4311590068 hasConceptScore W4311590068C167672396 @default.
- W4311590068 hasConceptScore W4311590068C203014093 @default.
- W4311590068 hasConceptScore W4311590068C2777701055 @default.
- W4311590068 hasConceptScore W4311590068C2777877232 @default.
- W4311590068 hasConceptScore W4311590068C2779013556 @default.
- W4311590068 hasConceptScore W4311590068C2779118045 @default.
- W4311590068 hasConceptScore W4311590068C502942594 @default.
- W4311590068 hasConceptScore W4311590068C71924100 @default.