FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311590411> ?p ?o ?g. }

• W4311590411 endingPage "2057" @default.
• W4311590411 startingPage "2044" @default.
• W4311590411 abstract "Omega-3 fatty acids from fish oil (FO) and selenium (Se) potentiate some conventional therapies and have anticancer immune potential. This study aims to determine whether FO/Se modulates G-protein-coupled polyunsaturated fatty acid receptors (GPR-40 and GPR-120) and selenoproteins (Sel-H, Sel-W, and GPx4), and increases the therapeutic effect of doxorubicin in a dose-dependent manner on triple-negative breast cancer (TNBC) mouse. Mice were randomized into 5 groups (n = 7/group) and treated with physiological saline (control), low-dose doxorubicin, and doxorubicin in combination with low, medium, or high doses of FO/Se. The expression of signaling molecules in tumors was determined by measuring either mRNA or protein expression. Compared with doxorubicin alone, combination treatment resulted in lower tumor sizes and fewer overall metastasis, lower GPR-40 mRNA levels, and higher expression of all selenoproteins. Doxorubicin-FO/Se combination treatment decreased expression of membrane EGFR and FGFR, down-regulated downstream PI3K/AKT/mTOR, MAPK/ERK, and JAK2/c-Src/STAT3 signaling, increased tumor suppressor PTEN/TSC1/TSC2 expression and P53 activation, and suppressed oncogenic transcription factor expression. Dose-dependent inhibition of proliferation index Ki-67, cell cycle, and stem-cell-related markers were observed. Decreased immune check-points PD-L1/CTLA-4/Foxp3/CD86 and increased PD-1/CD28/IL-2 expression was also found. These observations suggest that the nutritional supplements FO/Se increase the chemotherapeutic efficacy of doxorubicin against TNBC by modulating GPR-40 and selenoprotein and targeting multiple signaling pathways in tumor tissues." @default.
• W4311590411 created "2022-12-27" @default.
• W4311590411 creator A5043555656 @default.
• W4311590411 creator A5045326776 @default.
• W4311590411 creator A5045731651 @default.
• W4311590411 creator A5047378720 @default.
• W4311590411 creator A5056803518 @default.
• W4311590411 creator A5066218543 @default.
• W4311590411 creator A5066252639 @default.
• W4311590411 creator A5076038503 @default.
• W4311590411 date "2022-01-01" @default.
• W4311590411 modified "2023-10-14" @default.
• W4311590411 title "Fish Oil and Selenium with Doxorubicin Modulates Expression of Fatty Acid Receptors and Selenoproteins, and Targets Multiple Anti-Cancer Signaling in Triple-negative Breast Cancer Tumors" @default.
• W4311590411 cites W1546056545 @default.
• W4311590411 cites W162480160 @default.
• W4311590411 cites W1939816771 @default.
• W4311590411 cites W1977706521 @default.
• W4311590411 cites W2006438942 @default.
• W4311590411 cites W2035975926 @default.
• W4311590411 cites W2038713860 @default.
• W4311590411 cites W2118605519 @default.
• W4311590411 cites W2123469081 @default.
• W4311590411 cites W2135088554 @default.
• W4311590411 cites W2167229817 @default.
• W4311590411 cites W2167926350 @default.
• W4311590411 cites W2168491140 @default.
• W4311590411 cites W2253000935 @default.
• W4311590411 cites W2272577048 @default.
• W4311590411 cites W2317055602 @default.
• W4311590411 cites W2333884632 @default.
• W4311590411 cites W2734696975 @default.
• W4311590411 cites W2761872509 @default.
• W4311590411 cites W2783471471 @default.
• W4311590411 cites W2792088038 @default.
• W4311590411 cites W2794149351 @default.
• W4311590411 cites W2794502676 @default.
• W4311590411 cites W2887014156 @default.
• W4311590411 cites W2887608949 @default.
• W4311590411 cites W2889897913 @default.
• W4311590411 cites W2894464630 @default.
• W4311590411 cites W2895674659 @default.
• W4311590411 cites W2912993657 @default.
• W4311590411 cites W2913640933 @default.
• W4311590411 cites W2913906131 @default.
• W4311590411 cites W2938395656 @default.
• W4311590411 cites W2955744180 @default.
• W4311590411 cites W2961045531 @default.
• W4311590411 cites W2980207380 @default.
• W4311590411 cites W3000598302 @default.
• W4311590411 cites W3003322622 @default.
• W4311590411 cites W3012440210 @default.
• W4311590411 cites W3024789895 @default.
• W4311590411 cites W3045964587 @default.
• W4311590411 cites W3083138954 @default.
• W4311590411 cites W3087612301 @default.
• W4311590411 cites W3097277890 @default.
• W4311590411 cites W3110928893 @default.
• W4311590411 cites W3123582767 @default.
• W4311590411 cites W3128049872 @default.
• W4311590411 cites W3148452568 @default.
• W4311590411 cites W3183739288 @default.
• W4311590411 cites W3197431129 @default.
• W4311590411 doi "https://doi.org/10.7150/ijms.75848" @default.
• W4311590411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36483592" @default.
• W4311590411 hasPublicationYear "2022" @default.
• W4311590411 type Work @default.
• W4311590411 citedByCount "1" @default.
• W4311590411 countsByYear W43115904112023 @default.
• W4311590411 crossrefType "journal-article" @default.
• W4311590411 hasAuthorship W4311590411A5043555656 @default.
• W4311590411 hasAuthorship W4311590411A5045326776 @default.
• W4311590411 hasAuthorship W4311590411A5045731651 @default.
• W4311590411 hasAuthorship W4311590411A5047378720 @default.
• W4311590411 hasAuthorship W4311590411A5056803518 @default.
• W4311590411 hasAuthorship W4311590411A5066218543 @default.
• W4311590411 hasAuthorship W4311590411A5066252639 @default.
• W4311590411 hasAuthorship W4311590411A5076038503 @default.
• W4311590411 hasBestOaLocation W43115904111 @default.
• W4311590411 hasConcept C126322002 @default.
• W4311590411 hasConcept C185592680 @default.
• W4311590411 hasConcept C2776694085 @default.
• W4311590411 hasConcept C2781303535 @default.
• W4311590411 hasConcept C502942594 @default.
• W4311590411 hasConcept C62478195 @default.
• W4311590411 hasConcept C71924100 @default.
• W4311590411 hasConcept C75217442 @default.
• W4311590411 hasConcept C86554907 @default.
• W4311590411 hasConcept C86803240 @default.
• W4311590411 hasConcept C95444343 @default.
• W4311590411 hasConceptScore W4311590411C126322002 @default.
• W4311590411 hasConceptScore W4311590411C185592680 @default.
• W4311590411 hasConceptScore W4311590411C2776694085 @default.
• W4311590411 hasConceptScore W4311590411C2781303535 @default.
• W4311590411 hasConceptScore W4311590411C502942594 @default.
• W4311590411 hasConceptScore W4311590411C62478195 @default.
• W4311590411 hasConceptScore W4311590411C71924100 @default.
• W4311590411 hasConceptScore W4311590411C75217442 @default.
• W4311590411 hasConceptScore W4311590411C86554907 @default.

• next