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- W4311595554 abstract "Nitrogen-bearing rings are common features in the molecular structures of modern drugs, with chiral δ-lactams being an important subclass due to their known pharmacological properties. Catalytic dearomatization of preactivated pyridinium ion derivatives emerged as a powerful method for the rapid construction of chiral N-heterocycles. However, direct catalytic dearomatization of simple pyridine derivatives are scarce and methodologies yielding chiral δ-lactams are yet to be developed. Herein, we describe an enantioselective C4-dearomatization of methoxypyridine derivatives for the preparation of functionalised enantioenriched δ-lactams using chiral copper catalysis. Experimental 13 C kinetic isotope effects and density functional theory calculations shed light on the reaction mechanism and the origin of enantioselectivity." @default.
- W4311595554 created "2022-12-27" @default.
- W4311595554 creator A5012293576 @default.
- W4311595554 creator A5028901741 @default.
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- W4311595554 date "2023-01-18" @default.
- W4311595554 modified "2023-10-14" @default.
- W4311595554 title "Catalytic Access to Chiral <i>δ</i>‐Lactams via Nucleophilic Dearomatization of Pyridine Derivatives" @default.
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- W4311595554 doi "https://doi.org/10.1002/anie.202217328" @default.
- W4311595554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36522289" @default.
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