FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311604602> ?p ?o ?g. }

• W4311604602 abstract "The endogenous plasmid pUTI89 harbored by the uropathogenic Escherichia coli (UPEC) strain UTI89 plays an important role in the acute stage of infection. The partitioning gene parB is important for stable inheritance of pUTI89. However, the function of partitioning genes located on the plasmid in pathogenesis of UPEC still needs to be further investigated. In the present study, we observed that disruption of the parB gene leads to a deficiency in biofilm formation in vitro. Moreover, in a mixed infection with the wild type strain and the parB mutant, in an ascending UTI mouse model, the mutant displayed a lower bacterial burden in the bladder and kidneys, not only at the acute infection stage but also extending to 72 hours post infection. However, in the single infection test, the reduced colonization ability of the parB mutant was only observed at six hpi in the bladder, but not in the kidneys. The colonization capacity in vivo of the parB-complemented strain was recovered. qRT-PCR assay suggested that ParB could be a global regulator, influencing the expression of genes located on both the endogenous plasmid and chromosome, while the gene parA or the operon parAB could not. Our study demonstrates that parB contributes to the virulence of UPEC by influencing biofilm formation and proposes that the parB gene of the endogenous plasmid could regulate gene expression globally." @default.
• W4311604602 created "2022-12-27" @default.
• W4311604602 creator A5007360264 @default.
• W4311604602 creator A5017414844 @default.
• W4311604602 creator A5035569738 @default.
• W4311604602 creator A5036254947 @default.
• W4311604602 creator A5065315322 @default.
• W4311604602 date "2022-12-16" @default.
• W4311604602 modified "2023-09-26" @default.
• W4311604602 title "Plasmid parB contributes to uropathogenic Escherichia coli colonization in vivo by acting on biofilm formation and global gene regulation" @default.
• W4311604602 cites W1532814292 @default.
• W4311604602 cites W1550557848 @default.
• W4311604602 cites W1648827992 @default.
• W4311604602 cites W1964004889 @default.
• W4311604602 cites W1970455873 @default.
• W4311604602 cites W1973150982 @default.
• W4311604602 cites W1987331617 @default.
• W4311604602 cites W2012031105 @default.
• W4311604602 cites W2019875425 @default.
• W4311604602 cites W2028478260 @default.
• W4311604602 cites W2059872230 @default.
• W4311604602 cites W2065164437 @default.
• W4311604602 cites W2067656740 @default.
• W4311604602 cites W2067759009 @default.
• W4311604602 cites W2069784921 @default.
• W4311604602 cites W2097739005 @default.
• W4311604602 cites W2104923518 @default.
• W4311604602 cites W2107277218 @default.
• W4311604602 cites W2108998157 @default.
• W4311604602 cites W2116137883 @default.
• W4311604602 cites W2117663119 @default.
• W4311604602 cites W2126017466 @default.
• W4311604602 cites W2128311206 @default.
• W4311604602 cites W2138779519 @default.
• W4311604602 cites W2146706999 @default.
• W4311604602 cites W2146996551 @default.
• W4311604602 cites W2151645494 @default.
• W4311604602 cites W2169024982 @default.
• W4311604602 cites W2192080449 @default.
• W4311604602 cites W2229890647 @default.
• W4311604602 cites W2347158652 @default.
• W4311604602 cites W2534093914 @default.
• W4311604602 cites W2914415623 @default.
• W4311604602 cites W2947544293 @default.
• W4311604602 cites W2995522508 @default.
• W4311604602 cites W3043339164 @default.
• W4311604602 cites W3185270078 @default.
• W4311604602 cites W746378013 @default.
• W4311604602 doi "https://doi.org/10.3389/fmolb.2022.1053888" @default.
• W4311604602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36589237" @default.
• W4311604602 hasPublicationYear "2022" @default.
• W4311604602 type Work @default.
• W4311604602 citedByCount "0" @default.
• W4311604602 crossrefType "journal-article" @default.
• W4311604602 hasAuthorship W4311604602A5007360264 @default.
• W4311604602 hasAuthorship W4311604602A5017414844 @default.
• W4311604602 hasAuthorship W4311604602A5035569738 @default.
• W4311604602 hasAuthorship W4311604602A5036254947 @default.
• W4311604602 hasAuthorship W4311604602A5065315322 @default.
• W4311604602 hasBestOaLocation W43116046021 @default.
• W4311604602 hasConcept C104317684 @default.
• W4311604602 hasConcept C143065580 @default.
• W4311604602 hasConcept C203075996 @default.
• W4311604602 hasConcept C22744801 @default.
• W4311604602 hasConcept C523546767 @default.
• W4311604602 hasConcept C54355233 @default.
• W4311604602 hasConcept C547475151 @default.
• W4311604602 hasConcept C58123911 @default.
• W4311604602 hasConcept C60987743 @default.
• W4311604602 hasConcept C86803240 @default.
• W4311604602 hasConcept C89423630 @default.
• W4311604602 hasConceptScore W4311604602C104317684 @default.
• W4311604602 hasConceptScore W4311604602C143065580 @default.
• W4311604602 hasConceptScore W4311604602C203075996 @default.
• W4311604602 hasConceptScore W4311604602C22744801 @default.
• W4311604602 hasConceptScore W4311604602C523546767 @default.
• W4311604602 hasConceptScore W4311604602C54355233 @default.
• W4311604602 hasConceptScore W4311604602C547475151 @default.
• W4311604602 hasConceptScore W4311604602C58123911 @default.
• W4311604602 hasConceptScore W4311604602C60987743 @default.
• W4311604602 hasConceptScore W4311604602C86803240 @default.
• W4311604602 hasConceptScore W4311604602C89423630 @default.
• W4311604602 hasFunder F4320321001 @default.
• W4311604602 hasLocation W43116046021 @default.
• W4311604602 hasLocation W43116046022 @default.
• W4311604602 hasLocation W43116046023 @default.
• W4311604602 hasLocation W43116046024 @default.
• W4311604602 hasLocation W43116046025 @default.
• W4311604602 hasOpenAccess W4311604602 @default.
• W4311604602 hasPrimaryLocation W43116046021 @default.
• W4311604602 hasRelatedWork W1758289648 @default.
• W4311604602 hasRelatedWork W2038157797 @default.
• W4311604602 hasRelatedWork W2045070223 @default.
• W4311604602 hasRelatedWork W2107871141 @default.
• W4311604602 hasRelatedWork W2118762463 @default.
• W4311604602 hasRelatedWork W2154140056 @default.
• W4311604602 hasRelatedWork W2318106903 @default.
• W4311604602 hasRelatedWork W2590948392 @default.
• W4311604602 hasRelatedWork W2739219804 @default.
• W4311604602 hasRelatedWork W3172068086 @default.

• next