Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311608240> ?p ?o ?g. }
- W4311608240 endingPage "700" @default.
- W4311608240 startingPage "683" @default.
- W4311608240 abstract "Abstract Ciprofloxacin-Piperazine C-7 linked quinoline derivatives 6a–c and 8a–c were synthesized and investigated for their antibacterial, antifungal, and anti-proliferative activities. Ciprofloxacin-quinoline-4-yl-1,3,4 oxadiazoles 6a and 6b showed promising anticancer activity against SR- leukemia and UO-31 renal cancer cell lines. The hybrids 8a–c and compound 6b exhibited noticeable antifungal activities against C. Albicans ; 8a experienced the most potent antifungal activity compared to Itraconazole with MICs of 21.88 µg/mL and 11.22 µg/mL; respectively. Most of derivatives displayed better antibacterial activity than the parent ciprofloxacin against all the tested strains. Compound 6b was the most potent against the highly resistant Gram-negative K. pneumoniae with MIC 16.96 of µg/mL relative to the parent ciprofloxacin (MIC = 29.51 µg/mL). Docking studies of the tested hydrides in the active site of Topo IV enzyme of K. pneumoniae ( 5EIX ) and S. aureus gyrase ( 2XCT) indicate that they had stronger binding affinity in both enzymes than ciprofloxacin but have different binding interactions. The hybrid 6b could be considered a promising lead compound for finding new dual antibacterial/anticancer agents. Moreover, Compound 8a could be a lead for discovering new dual antibacterial/antifungal agents. Graphical abstract" @default.
- W4311608240 created "2022-12-27" @default.
- W4311608240 creator A5033562597 @default.
- W4311608240 creator A5034800239 @default.
- W4311608240 creator A5044481467 @default.
- W4311608240 creator A5072393450 @default.
- W4311608240 date "2022-12-06" @default.
- W4311608240 modified "2023-10-15" @default.
- W4311608240 title "Design, synthesis, and biological investigation of quinoline/ciprofloxacin hybrids as antimicrobial and anti-proliferative agents" @default.
- W4311608240 cites W1602855316 @default.
- W4311608240 cites W1874501207 @default.
- W4311608240 cites W1979230737 @default.
- W4311608240 cites W2002284310 @default.
- W4311608240 cites W2004503571 @default.
- W4311608240 cites W2015160278 @default.
- W4311608240 cites W2017758807 @default.
- W4311608240 cites W2019332449 @default.
- W4311608240 cites W2026553441 @default.
- W4311608240 cites W2032247032 @default.
- W4311608240 cites W2035191998 @default.
- W4311608240 cites W2043035052 @default.
- W4311608240 cites W2054948698 @default.
- W4311608240 cites W2062972160 @default.
- W4311608240 cites W2067368474 @default.
- W4311608240 cites W2069397868 @default.
- W4311608240 cites W2070770172 @default.
- W4311608240 cites W2075733775 @default.
- W4311608240 cites W2080705284 @default.
- W4311608240 cites W2081183202 @default.
- W4311608240 cites W2086586135 @default.
- W4311608240 cites W2091078895 @default.
- W4311608240 cites W2119085884 @default.
- W4311608240 cites W2120893358 @default.
- W4311608240 cites W2129319023 @default.
- W4311608240 cites W2130948107 @default.
- W4311608240 cites W2137088409 @default.
- W4311608240 cites W2139554217 @default.
- W4311608240 cites W2142408897 @default.
- W4311608240 cites W2146778078 @default.
- W4311608240 cites W2152069719 @default.
- W4311608240 cites W2159574231 @default.
- W4311608240 cites W2163990308 @default.
- W4311608240 cites W2164956573 @default.
- W4311608240 cites W2175250289 @default.
- W4311608240 cites W2320456355 @default.
- W4311608240 cites W2321417224 @default.
- W4311608240 cites W2346464968 @default.
- W4311608240 cites W2759191832 @default.
- W4311608240 cites W2788701548 @default.
- W4311608240 cites W2791460195 @default.
- W4311608240 cites W2807176395 @default.
- W4311608240 cites W2910011013 @default.
- W4311608240 cites W2949170244 @default.
- W4311608240 cites W2987344358 @default.
- W4311608240 cites W3098849776 @default.
- W4311608240 cites W3156588285 @default.
- W4311608240 cites W4293215167 @default.
- W4311608240 doi "https://doi.org/10.1007/s13738-022-02704-7" @default.
- W4311608240 hasPublicationYear "2022" @default.
- W4311608240 type Work @default.
- W4311608240 citedByCount "0" @default.
- W4311608240 crossrefType "journal-article" @default.
- W4311608240 hasAuthorship W4311608240A5033562597 @default.
- W4311608240 hasAuthorship W4311608240A5034800239 @default.
- W4311608240 hasAuthorship W4311608240A5044481467 @default.
- W4311608240 hasAuthorship W4311608240A5072393450 @default.
- W4311608240 hasBestOaLocation W43116082401 @default.
- W4311608240 hasConcept C159110408 @default.
- W4311608240 hasConcept C178790620 @default.
- W4311608240 hasConcept C185592680 @default.
- W4311608240 hasConcept C21951064 @default.
- W4311608240 hasConcept C2776309666 @default.
- W4311608240 hasConcept C2777907353 @default.
- W4311608240 hasConcept C2778512257 @default.
- W4311608240 hasConcept C2779922871 @default.
- W4311608240 hasConcept C2780104969 @default.
- W4311608240 hasConcept C2780917455 @default.
- W4311608240 hasConcept C41685203 @default.
- W4311608240 hasConcept C4937899 @default.
- W4311608240 hasConcept C501593827 @default.
- W4311608240 hasConcept C523546767 @default.
- W4311608240 hasConcept C54355233 @default.
- W4311608240 hasConcept C55493867 @default.
- W4311608240 hasConcept C71240020 @default.
- W4311608240 hasConcept C71924100 @default.
- W4311608240 hasConcept C86803240 @default.
- W4311608240 hasConcept C89423630 @default.
- W4311608240 hasConceptScore W4311608240C159110408 @default.
- W4311608240 hasConceptScore W4311608240C178790620 @default.
- W4311608240 hasConceptScore W4311608240C185592680 @default.
- W4311608240 hasConceptScore W4311608240C21951064 @default.
- W4311608240 hasConceptScore W4311608240C2776309666 @default.
- W4311608240 hasConceptScore W4311608240C2777907353 @default.
- W4311608240 hasConceptScore W4311608240C2778512257 @default.
- W4311608240 hasConceptScore W4311608240C2779922871 @default.
- W4311608240 hasConceptScore W4311608240C2780104969 @default.
- W4311608240 hasConceptScore W4311608240C2780917455 @default.
- W4311608240 hasConceptScore W4311608240C41685203 @default.