Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311622393> ?p ?o ?g. }
- W4311622393 abstract "Abstract Saxagliptin (Saxa) belongs to a new generation of antidiabetic pharmaceutical compounds used in combination with healthy diet and exercise to lower blood glucose levels in patients with type 2 diabetes mellitus (T2DM). In this work, we report for the first time a molecularly imprinted polymer (MIP) based electrochemical sensor for the determination of Saxa. Computational calculations were performed, based on which five MIPs were synthesized using Saxa as a template, itaconic acid as a monomer, crosslinked with ethylene glycol dimethacrylate and Di methyl sulfoxide (DMSO) as a porogen with different ratios. Non‐covalent interaction (NCI) analysis has been also conducted, and the obtained isosurface analysis was used for graphical visualization of NCI that could occur in real space as well as for the discrimination between hydrogen bond interaction, Van Der Waals attraction and spatial repulsion. The optimized polymer was incorporated as a modifier for designing an electrochemical sensor comprising MIP and Multiwalled carbon nanotubes (MwCNT) within carbon paste electrode (CPE). The operational variables including incubation time, pH, scan rate, and accumulation time were optimized. The sensor showed linearity over the concentration range (1 × 10 −9 –1 × 10 −15 M) with low limit of detection (LOD) 8 × 10 −16 and 2 × 10 −16 M on using DPV and EIS, respectively. The sensor was successfully applied for pharmaceutical formulations, urine, and human serum samples with recovery range between 97.45–100.64 %." @default.
- W4311622393 created "2022-12-27" @default.
- W4311622393 creator A5009482744 @default.
- W4311622393 creator A5015335550 @default.
- W4311622393 creator A5069865152 @default.
- W4311622393 creator A5084287357 @default.
- W4311622393 creator A5086577940 @default.
- W4311622393 date "2023-02-06" @default.
- W4311622393 modified "2023-10-02" @default.
- W4311622393 title "Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin" @default.
- W4311622393 cites W1966394825 @default.
- W4311622393 cites W1971198008 @default.
- W4311622393 cites W1976005387 @default.
- W4311622393 cites W1978530704 @default.
- W4311622393 cites W2008569521 @default.
- W4311622393 cites W2011127335 @default.
- W4311622393 cites W2029055551 @default.
- W4311622393 cites W2030102515 @default.
- W4311622393 cites W2032067043 @default.
- W4311622393 cites W2039668215 @default.
- W4311622393 cites W2051196482 @default.
- W4311622393 cites W2062323858 @default.
- W4311622393 cites W2087179216 @default.
- W4311622393 cites W2104919283 @default.
- W4311622393 cites W2105798688 @default.
- W4311622393 cites W2132525235 @default.
- W4311622393 cites W2133034433 @default.
- W4311622393 cites W2161370795 @default.
- W4311622393 cites W2171865586 @default.
- W4311622393 cites W2335653546 @default.
- W4311622393 cites W2501986109 @default.
- W4311622393 cites W2556204610 @default.
- W4311622393 cites W2561929946 @default.
- W4311622393 cites W2587328774 @default.
- W4311622393 cites W2604251581 @default.
- W4311622393 cites W2610065067 @default.
- W4311622393 cites W2801234501 @default.
- W4311622393 cites W2887498527 @default.
- W4311622393 cites W2897156637 @default.
- W4311622393 cites W2903340139 @default.
- W4311622393 cites W2903852367 @default.
- W4311622393 cites W2905059131 @default.
- W4311622393 cites W2906552187 @default.
- W4311622393 cites W2907433443 @default.
- W4311622393 cites W2910063978 @default.
- W4311622393 cites W2924059973 @default.
- W4311622393 cites W2953385245 @default.
- W4311622393 cites W2956386480 @default.
- W4311622393 cites W3005099627 @default.
- W4311622393 cites W3016159331 @default.
- W4311622393 cites W3044690508 @default.
- W4311622393 cites W3045552121 @default.
- W4311622393 cites W3046327406 @default.
- W4311622393 cites W3046744780 @default.
- W4311622393 cites W3108229809 @default.
- W4311622393 cites W3121345183 @default.
- W4311622393 cites W3124533962 @default.
- W4311622393 cites W3127601967 @default.
- W4311622393 cites W3128434710 @default.
- W4311622393 cites W3150772811 @default.
- W4311622393 cites W3172255251 @default.
- W4311622393 cites W3174695264 @default.
- W4311622393 cites W3187774525 @default.
- W4311622393 cites W3195642105 @default.
- W4311622393 cites W3202450911 @default.
- W4311622393 cites W3202608861 @default.
- W4311622393 cites W3204921867 @default.
- W4311622393 cites W3205343026 @default.
- W4311622393 cites W3208821450 @default.
- W4311622393 cites W3213795439 @default.
- W4311622393 cites W3217622173 @default.
- W4311622393 cites W4200305309 @default.
- W4311622393 cites W4200413478 @default.
- W4311622393 cites W4205357958 @default.
- W4311622393 cites W4205401557 @default.
- W4311622393 cites W4207085117 @default.
- W4311622393 cites W4214592555 @default.
- W4311622393 cites W4221014346 @default.
- W4311622393 cites W4223487457 @default.
- W4311622393 cites W4223571025 @default.
- W4311622393 cites W4224248765 @default.
- W4311622393 cites W4224251284 @default.
- W4311622393 doi "https://doi.org/10.1002/elan.202200313" @default.
- W4311622393 hasPublicationYear "2023" @default.
- W4311622393 type Work @default.
- W4311622393 citedByCount "1" @default.
- W4311622393 countsByYear W43116223932023 @default.
- W4311622393 crossrefType "journal-article" @default.
- W4311622393 hasAuthorship W4311622393A5009482744 @default.
- W4311622393 hasAuthorship W4311622393A5015335550 @default.
- W4311622393 hasAuthorship W4311622393A5069865152 @default.
- W4311622393 hasAuthorship W4311622393A5084287357 @default.
- W4311622393 hasAuthorship W4311622393A5086577940 @default.
- W4311622393 hasConcept C118792377 @default.
- W4311622393 hasConcept C119128265 @default.
- W4311622393 hasConcept C134018914 @default.
- W4311622393 hasConcept C13965031 @default.
- W4311622393 hasConcept C147789679 @default.
- W4311622393 hasConcept C161790260 @default.
- W4311622393 hasConcept C162602672 @default.