Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311624411> ?p ?o ?g. }
- W4311624411 endingPage "9549" @default.
- W4311624411 startingPage "9535" @default.
- W4311624411 abstract "Multiple myeloma (MM) is a complex disease driven by numerous genetic and epigenetic alterations that are acquired over time. Despite recent progress in the understanding of MM pathobiology and the availability of innovative drugs, which have pronounced clinical outcome, this malignancy eventually progresses to a drug-resistant lethal stage and, thus, novel therapeutic drugs/models always play an important role in effective management of MM. Modulation of tumor microenvironment is one of the hallmarks of cancer biology, including MM, which affects the myeloma genomic architecture and disease progression subtly through chromatin modifications. The bone marrow niche has a prime role in progression, survival, and drug resistance of multiple myeloma cells. Therefore, it is important to develop means for targeting the ecosystem between multiple myeloma bone marrow microenvironment and chromatin remodeling. Extensive gene expression profile analysis has indeed provided the framework for new risk stratification of MM patients and identifying novel molecular targets and therapeutics. However, key tumor microenvironment factors/immune cells and their interactions with chromatin remodeling complex proteins that drive MM cell growth and progression remain grossly undefined." @default.
- W4311624411 created "2022-12-27" @default.
- W4311624411 creator A5014170615 @default.
- W4311624411 creator A5015176078 @default.
- W4311624411 date "2022-12-05" @default.
- W4311624411 modified "2023-10-13" @default.
- W4311624411 title "Molecular Crosstalk between Chromatin Remodeling and Tumor Microenvironment in Multiple Myeloma" @default.
- W4311624411 cites W1533898383 @default.
- W4311624411 cites W156974138 @default.
- W4311624411 cites W1660332899 @default.
- W4311624411 cites W1868397411 @default.
- W4311624411 cites W1874408158 @default.
- W4311624411 cites W1911375134 @default.
- W4311624411 cites W1968326919 @default.
- W4311624411 cites W1968628080 @default.
- W4311624411 cites W1969705003 @default.
- W4311624411 cites W1976556343 @default.
- W4311624411 cites W1981030303 @default.
- W4311624411 cites W1986506949 @default.
- W4311624411 cites W1988924112 @default.
- W4311624411 cites W1989269356 @default.
- W4311624411 cites W1989968124 @default.
- W4311624411 cites W1996840022 @default.
- W4311624411 cites W2002032142 @default.
- W4311624411 cites W2005718040 @default.
- W4311624411 cites W2010552629 @default.
- W4311624411 cites W2014051864 @default.
- W4311624411 cites W2015520692 @default.
- W4311624411 cites W2016024994 @default.
- W4311624411 cites W2017682198 @default.
- W4311624411 cites W2017719257 @default.
- W4311624411 cites W2018887276 @default.
- W4311624411 cites W2020103166 @default.
- W4311624411 cites W2022385796 @default.
- W4311624411 cites W2030956730 @default.
- W4311624411 cites W2031496441 @default.
- W4311624411 cites W2034817882 @default.
- W4311624411 cites W2038329170 @default.
- W4311624411 cites W2038545166 @default.
- W4311624411 cites W2038781914 @default.
- W4311624411 cites W2041357218 @default.
- W4311624411 cites W2043984986 @default.
- W4311624411 cites W2045691095 @default.
- W4311624411 cites W2048600214 @default.
- W4311624411 cites W2054540776 @default.
- W4311624411 cites W2054638358 @default.
- W4311624411 cites W2059997542 @default.
- W4311624411 cites W2060930865 @default.
- W4311624411 cites W2061123122 @default.
- W4311624411 cites W2065210647 @default.
- W4311624411 cites W2065577291 @default.
- W4311624411 cites W2067680442 @default.
- W4311624411 cites W2068065167 @default.
- W4311624411 cites W2075428268 @default.
- W4311624411 cites W2077330278 @default.
- W4311624411 cites W2082097313 @default.
- W4311624411 cites W2089030718 @default.
- W4311624411 cites W2091835858 @default.
- W4311624411 cites W2092246736 @default.
- W4311624411 cites W2104195581 @default.
- W4311624411 cites W2106439318 @default.
- W4311624411 cites W2107775880 @default.
- W4311624411 cites W2116429223 @default.
- W4311624411 cites W2117776343 @default.
- W4311624411 cites W2118934629 @default.
- W4311624411 cites W2124076790 @default.
- W4311624411 cites W2124282663 @default.
- W4311624411 cites W2138746101 @default.
- W4311624411 cites W2140069364 @default.
- W4311624411 cites W2142793991 @default.
- W4311624411 cites W2146946610 @default.
- W4311624411 cites W2149053153 @default.
- W4311624411 cites W2161232450 @default.
- W4311624411 cites W2162117160 @default.
- W4311624411 cites W2164373700 @default.
- W4311624411 cites W2168307206 @default.
- W4311624411 cites W2194404144 @default.
- W4311624411 cites W2261579786 @default.
- W4311624411 cites W2264691042 @default.
- W4311624411 cites W2288611291 @default.
- W4311624411 cites W2328864297 @default.
- W4311624411 cites W2330541121 @default.
- W4311624411 cites W2338457593 @default.
- W4311624411 cites W2396599501 @default.
- W4311624411 cites W2475153636 @default.
- W4311624411 cites W2500913424 @default.
- W4311624411 cites W2529729253 @default.
- W4311624411 cites W2549396793 @default.
- W4311624411 cites W2560134060 @default.
- W4311624411 cites W2560827811 @default.
- W4311624411 cites W2566175157 @default.
- W4311624411 cites W2589859055 @default.
- W4311624411 cites W2592644822 @default.
- W4311624411 cites W2594100081 @default.
- W4311624411 cites W2603753881 @default.
- W4311624411 cites W2607044226 @default.
- W4311624411 cites W2624346565 @default.
- W4311624411 cites W2768869002 @default.