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- W4311638863 abstract "Iron is an essential trace element which mainly involves in the metabolism of neurotransmitters and myelin formation in the nervous system. However, its high redox potential can exacerbate bodily oxidative stress and toxicity under extreme concentrations. Thus, brain iron homeostasis is vital to brain health, as tight iron regulations in the CNS prevents abnormal iron localization and catastrophic oxidative damage to cellular structures and components. As such, it is hypothesized that iron dyshomeostasis is strongly associated with the occurrence of neurodegenerative diseases such as AD. Therefore, it is of utmost importance to fully understand the fundamental mechanisms of brain iron metabolism and regulation to better study the beneficial and/or harmful roles of iron in AD. This book chapter presented the pathology of AD and the mechanism of action of iron in the principal pathways of AD development. It is concluded that iron could initiate and contribute to the pathology of AD, as it is significantly associated with key AD protein filaments of Aβ and τ hyperphosphorylation that leads to the accumulation of senile plaques and NFTs. Besides its ability to create free radicals, ferroptosis has been considered to be a significant factor in the neuronal loss of AD through brain cell necrosis and AD neurotoxicity. The ferroptosis pathway has then become a research hotspot by targeting the iron to invent new interventions to counter the onset of AD and its lethal effects on human health." @default.
- W4311638863 created "2022-12-27" @default.
- W4311638863 creator A5060276344 @default.
- W4311638863 creator A5081911114 @default.
- W4311638863 date "2022-12-17" @default.
- W4311638863 modified "2023-09-23" @default.
- W4311638863 title "Iron and Alzheimer’s Disease" @default.
- W4311638863 cites W1494932082 @default.
- W4311638863 cites W1520399944 @default.
- W4311638863 cites W1554868992 @default.
- W4311638863 cites W1558835554 @default.
- W4311638863 cites W1559294607 @default.
- W4311638863 cites W1583101023 @default.
- W4311638863 cites W1715245971 @default.
- W4311638863 cites W1752793417 @default.
- W4311638863 cites W1772300761 @default.
- W4311638863 cites W1825967587 @default.
- W4311638863 cites W1904458203 @default.
- W4311638863 cites W1933803332 @default.
- W4311638863 cites W1948712038 @default.
- W4311638863 cites W1966777603 @default.
- W4311638863 cites W1968771810 @default.
- W4311638863 cites W1969061171 @default.
- W4311638863 cites W1970031775 @default.
- W4311638863 cites W1970096539 @default.
- W4311638863 cites W1970830035 @default.
- W4311638863 cites W1972856320 @default.
- W4311638863 cites W1979101450 @default.
- W4311638863 cites W1979369962 @default.
- W4311638863 cites W1980560945 @default.
- W4311638863 cites W1981238903 @default.
- W4311638863 cites W1983588767 @default.
- W4311638863 cites W1989420290 @default.
- W4311638863 cites W1993877143 @default.
- W4311638863 cites W1994358095 @default.
- W4311638863 cites W1997183854 @default.
- W4311638863 cites W1997849651 @default.
- W4311638863 cites W1999794509 @default.
- W4311638863 cites W2001692959 @default.
- W4311638863 cites W2005585076 @default.
- W4311638863 cites W2006012000 @default.
- W4311638863 cites W2007794772 @default.
- W4311638863 cites W2008699078 @default.
- W4311638863 cites W2011538447 @default.
- W4311638863 cites W2012347766 @default.
- W4311638863 cites W2013708662 @default.
- W4311638863 cites W2015551931 @default.
- W4311638863 cites W2021720310 @default.
- W4311638863 cites W2022523341 @default.
- W4311638863 cites W2028034405 @default.
- W4311638863 cites W2028241732 @default.
- W4311638863 cites W2030249003 @default.
- W4311638863 cites W2035731717 @default.
- W4311638863 cites W2039069312 @default.
- W4311638863 cites W2039314393 @default.
- W4311638863 cites W2043870032 @default.
- W4311638863 cites W2045267711 @default.
- W4311638863 cites W2046690822 @default.
- W4311638863 cites W2049120554 @default.
- W4311638863 cites W2050769195 @default.
- W4311638863 cites W2050794707 @default.
- W4311638863 cites W2053486814 @default.
- W4311638863 cites W2061916198 @default.
- W4311638863 cites W2062197172 @default.
- W4311638863 cites W2062588841 @default.
- W4311638863 cites W2064618467 @default.
- W4311638863 cites W2066918975 @default.
- W4311638863 cites W2067448305 @default.
- W4311638863 cites W2072829138 @default.
- W4311638863 cites W2073271820 @default.
- W4311638863 cites W2081768689 @default.
- W4311638863 cites W2083715632 @default.
- W4311638863 cites W2084272059 @default.
- W4311638863 cites W2085440855 @default.
- W4311638863 cites W2097246500 @default.
- W4311638863 cites W2097416445 @default.
- W4311638863 cites W2103369856 @default.
- W4311638863 cites W2104552307 @default.
- W4311638863 cites W2105767248 @default.
- W4311638863 cites W2107606449 @default.
- W4311638863 cites W2108926627 @default.
- W4311638863 cites W2111698897 @default.
- W4311638863 cites W2112867510 @default.
- W4311638863 cites W2114655563 @default.
- W4311638863 cites W2115235249 @default.
- W4311638863 cites W2116030076 @default.
- W4311638863 cites W2118269481 @default.
- W4311638863 cites W2119657643 @default.
- W4311638863 cites W2124490243 @default.
- W4311638863 cites W2125411036 @default.
- W4311638863 cites W2126866334 @default.
- W4311638863 cites W2126915795 @default.
- W4311638863 cites W2128047032 @default.
- W4311638863 cites W2128613449 @default.
- W4311638863 cites W2130320001 @default.
- W4311638863 cites W2132871355 @default.
- W4311638863 cites W2134711807 @default.
- W4311638863 cites W2135812251 @default.