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- W4311648002 abstract "Plants of the <italic>Veratrum</italic> genus have been used throughout history for their emetic properties, rheumatism, and for the treatment of high blood pressure. However, inadvertent consumption of these plants, which resemble wild ramps, induces life threatening side effects attributable to an abundance of steroidal alkaloids. Several of the steroidal alkaloids from <italic>Veratrum</italic> spp. have been investigated for their ability to antagonize the Hedgehog (Hh) signaling pathway, a key pathway for embryonic development and cell proliferation. Uncontrolled activation of this pathway is linked to the development of various cancers, most notably basal cell carcinoma and acute myeloid leukemia. Additional investigation of <italic>Veratrum</italic> spp. may lead to the identification of novel alkaloids with potential to serve as chemotherapeutics. This project aimed to identify steroidal alkaloids in <italic>V. parviflorum</italic>, perform a toxicological investigation for the presence of these alkaloids in the blood and breast milk of patients who ingested <italic>V. parviflorum</italic>, and evaluate the bioactivity of these alkaloids for inhibiting the Hh signaling pathway. Four steroidal alkaloids were identified in the ethanolic extract of <italic>V. parviflorum</italic>: cyclopamine, veratramine, jervine, and muldamine. Cyclopamine, veratramine, and jervine were identified in patient blood while cyclopamine and veratramine were identified in patient breast milk. A bioactivity assessment of the <italic>V. parviflorum</italic> extract using Shh-Light cells suggested that there are additional compounds within the plant that are antagonistic to the Hh signaling pathway." @default.
- W4311648002 created "2022-12-27" @default.
- W4311648002 creator A5071419024 @default.
- W4311648002 date "2022-12-06" @default.
- W4311648002 modified "2023-09-27" @default.
- W4311648002 title "Toxicological Investigation, Identification, and Bioactivity Evaluation of Steroidal Alkaloids Derived from <i>Veratrum parviflorum</i>" @default.
- W4311648002 doi "https://doi.org/10.18122/td.1996.boisestate" @default.
- W4311648002 hasPublicationYear "2022" @default.
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