FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311651447> ?p ?o ?g. }

• W4311651447 abstract "Abstract Background Puberty is a time of considerable metabolic and hormonal changes associated with a physiological increase in peripheral tissue insulin resistance (IR). There is evidence that physiological IR does not resolve in youth who are obese, which may result in increased cardio-metabolic risk. Understanding the molecular and biological processes underlying the development of IR in puberty and the additional impact of obesity on these processes is crucial to prevent type 2 diabetes. Methods This is a longitudinal study based on the follow-up until puberty of a cohort of prepubertal Spanish boys and girls. The study population was composed of 139 children organized in a longitudinal approach of 90 subjects (47 females) and two cross-sectional approaches of 99 (52 females) and 130 (71 females) subjects for prepubertal and pubertal stages, respectively. Children were allocated into experimental groups according to their obesity and IR status before and after the onset of puberty. All participants presented blood DNA samples for GWAS and EWAS analyses. In 44 children of the pubertal stage, we counted on blood RNA samples for RNA-seq analysis. Results Our large-scale integrative molecular analysis identified novel blood multi-omics signatures (mapping the loci ABCG1, ESR1 and VASN , among others) significantly associated with IR longitudinal trajectories in children with obesity during pubertal maturation. Functional enrichment analysis revealed that identified loci participate in systemic metabolic pathways and sexual maturation processes relevant to the pathogenesis of IR in the context of puberty. Additional analyses on cardiometabolic and inflammatory phenotypes showed that blood DNAm patterns of some of the identified loci are further associated, beyond IR, with an overall risky-cardiometabolic profile in children. Serum protein levels of vasorin (VASN), one of the most promising novel biomarkers identified in this study, were further associated with IR in the pubertal stage. Conclusions To our knowledge, this is the first longitudinal multi-omics approach characterizing molecular blood alterations for IR and obesity during the metabolically critical period of puberty. Our results shed light on the molecular mechanisms underlying epigenetic alterations in obesity and propose novel and promising biomarkers for IR and metabolic alterations in children." @default.
• W4311651447 created "2022-12-27" @default.
• W4311651447 creator A5000969754 @default.
• W4311651447 creator A5004108820 @default.
• W4311651447 creator A5007045654 @default.
• W4311651447 creator A5009907472 @default.
• W4311651447 creator A5028178430 @default.
• W4311651447 creator A5031733933 @default.
• W4311651447 creator A5049170644 @default.
• W4311651447 creator A5056922543 @default.
• W4311651447 creator A5074229554 @default.
• W4311651447 creator A5076021671 @default.
• W4311651447 creator A5089947179 @default.
• W4311651447 date "2022-12-16" @default.
• W4311651447 modified "2023-10-16" @default.
• W4311651447 title "Integrative analysis of blood cells DNA methylation, transcriptomics and genomics identifies novel epigenetic regulatory mechanisms of insulin resistance during puberty in children with obesity" @default.
• W4311651447 cites W1513044495 @default.
• W4311651447 cites W1666284134 @default.
• W4311651447 cites W1808248494 @default.
• W4311651447 cites W1855280120 @default.
• W4311651447 cites W1925664165 @default.
• W4311651447 cites W2001795292 @default.
• W4311651447 cites W2020596859 @default.
• W4311651447 cites W2021664357 @default.
• W4311651447 cites W2025143098 @default.
• W4311651447 cites W2028260332 @default.
• W4311651447 cites W2035284391 @default.
• W4311651447 cites W2035293214 @default.
• W4311651447 cites W2036017373 @default.
• W4311651447 cites W2048755332 @default.
• W4311651447 cites W2064444082 @default.
• W4311651447 cites W2082122713 @default.
• W4311651447 cites W2093362931 @default.
• W4311651447 cites W2102278945 @default.
• W4311651447 cites W2107060225 @default.
• W4311651447 cites W2108234281 @default.
• W4311651447 cites W2114970231 @default.
• W4311651447 cites W2138207763 @default.
• W4311651447 cites W2138765302 @default.
• W4311651447 cites W2138928618 @default.
• W4311651447 cites W2146512944 @default.
• W4311651447 cites W2157709412 @default.
• W4311651447 cites W2158822657 @default.
• W4311651447 cites W2159422401 @default.
• W4311651447 cites W2159444491 @default.
• W4311651447 cites W2161209070 @default.
• W4311651447 cites W2161633633 @default.
• W4311651447 cites W2166968390 @default.
• W4311651447 cites W2264595441 @default.
• W4311651447 cites W2265429569 @default.
• W4311651447 cites W2279723444 @default.
• W4311651447 cites W2286048432 @default.
• W4311651447 cites W2316239158 @default.
• W4311651447 cites W2388227991 @default.
• W4311651447 cites W2469938949 @default.
• W4311651447 cites W2514674853 @default.
• W4311651447 cites W2523166651 @default.
• W4311651447 cites W2560048039 @default.
• W4311651447 cites W2560510482 @default.
• W4311651447 cites W2561301122 @default.
• W4311651447 cites W2606547955 @default.
• W4311651447 cites W2617316722 @default.
• W4311651447 cites W2619003201 @default.
• W4311651447 cites W2735376054 @default.
• W4311651447 cites W2751722940 @default.
• W4311651447 cites W2754385607 @default.
• W4311651447 cites W2757030954 @default.
• W4311651447 cites W2762689525 @default.
• W4311651447 cites W2790188097 @default.
• W4311651447 cites W2885294207 @default.
• W4311651447 cites W2900598537 @default.
• W4311651447 cites W2900850864 @default.
• W4311651447 cites W2903378764 @default.
• W4311651447 cites W2916077215 @default.
• W4311651447 cites W2921344398 @default.
• W4311651447 cites W2937020137 @default.
• W4311651447 cites W2939354927 @default.
• W4311651447 cites W2952742521 @default.
• W4311651447 cites W2963021014 @default.
• W4311651447 cites W2964720681 @default.
• W4311651447 cites W2972630199 @default.
• W4311651447 cites W2990273965 @default.
• W4311651447 cites W3003356907 @default.
• W4311651447 cites W3007736356 @default.
• W4311651447 cites W3035263498 @default.
• W4311651447 cites W3132172325 @default.
• W4311651447 cites W4210767115 @default.
• W4311651447 doi "https://doi.org/10.1101/2022.12.13.22283415" @default.
• W4311651447 hasPublicationYear "2022" @default.
• W4311651447 type Work @default.
• W4311651447 citedByCount "1" @default.
• W4311651447 countsByYear W43116514472023 @default.
• W4311651447 crossrefType "posted-content" @default.
• W4311651447 hasAuthorship W4311651447A5000969754 @default.
• W4311651447 hasAuthorship W4311651447A5004108820 @default.
• W4311651447 hasAuthorship W4311651447A5007045654 @default.
• W4311651447 hasAuthorship W4311651447A5009907472 @default.
• W4311651447 hasAuthorship W4311651447A5028178430 @default.
• W4311651447 hasAuthorship W4311651447A5031733933 @default.
• W4311651447 hasAuthorship W4311651447A5049170644 @default.

• next