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• W4311651448 endingPage "e0279372" @default.
• W4311651448 startingPage "e0279372" @default.
• W4311651448 abstract "Salmonella enterica serovars Typhimurium and Typhi are enteropathogens that differ in host range and the diseases that they cause. We found that exposure to a combination of hypotonicity and the detergent Triton X-100 significantly reduced the viability of the S . Typhi strain Ty2 but had no effect on the S . Typhimurium strain SL1344. Further analysis revealed that hypotonicity was the critical factor: incubation in distilled water alone was sufficient to kill Ty2, while the addition of sodium chloride inhibited killing in a dose-dependent manner. Ty2’s loss of viability in water was modified by culture conditions: bacteria grown in well-aerated shaking cultures were more susceptible than bacteria grown under less aerated static conditions. Ty2, like many S . Typhi clinical isolates, has an inactivating mutation in the rpoS gene, a transcriptional regulator of stress responses, whereas most S . Typhimurium strains, including SL1344, have the wild-type gene. Transformation of Ty2 with a plasmid expressing wild-type rpoS , but not the empty vector, significantly increased survival in distilled water. Moreover, an S . Typhi strain with wild-type rpoS had unimpaired survival in water. Inactivation of the wild-type gene in this strain significantly reduced survival, while replacement with an arabinose-inducible allele of rpoS restored viability in water under inducing conditions. Our observations on rpoS -dependent differences in susceptibility to hypotonic conditions may be relevant to the ability of S . Typhi and S . Typhimurium to tolerate the various environments they encounter during the infectious cycle. They also have implications for the handling of these organisms during experimental manipulations." @default.
• W4311651448 created "2022-12-27" @default.
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• W4311651448 date "2022-12-16" @default.
• W4311651448 modified "2023-10-18" @default.
• W4311651448 title "The rpoS gene confers resistance to low osmolarity conditions in Salmonella enterica serovar Typhi" @default.
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• W4311651448 doi "https://doi.org/10.1371/journal.pone.0279372" @default.
• W4311651448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36525423" @default.
• W4311651448 hasPublicationYear "2022" @default.
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