FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311652106> ?p ?o ?g. }

• W4311652106 abstract "Abstract Hantaan virus (HTNV) is a rodent-borne virus that can cause hemorrhagic fever with renal syndrome (HFRS) with a case fatality rate of 15% and is listed as a re-emerging infectious disease (REID) in China. At present, no specific therapeutic strategies against HTNV are available. Interferon (IFN) is a crucial antiviral molecular which can trigger interferon-stimulated genes (ISGs) expression through the Janus kinase-signal transducer and activator of transcription 1 (JAK-STAT) pathway. Large quantities of IFN produced at the late stage of HTNV infection could not effectively restrain viral replication, the mechanism of which is still unclear. Here, we identified the receptor-interacting protein kinase 3 (RIPK3), a critical molecular to mediate necroptosis, could facilitate HTNV infection by blocking JAK/STAT signaling. HTNV infection promoted the total expression level of RIPK3, but not the phosphorylation of RIPK3, thus not leading to cell death. RIPK3 ablation could restrain HTNV replication by enhancing the expression of multiple ISGs, during which the type I IFN generation did not strengthened. Exogenously expressing RIPK3 might hinder the host anti-hantaviral responses. RIPK3 −/− mice also maintained a robust ability to clear HTNV promptly with enhanced innate immune responses. Mechanistically, RIPK3 restricted STAT1 activation by bonding to STAT1 and blocking its phosphorylation sites, hence interfering with host IFN responses. Overall, these observations demonstrated a noncanonical function of RIPK3 during viral infection, and shed light on the novel evasion strategy of host innate immunity by HTNV." @default.
• W4311652106 created "2022-12-27" @default.
• W4311652106 creator A5022527850 @default.
• W4311652106 creator A5026089390 @default.
• W4311652106 creator A5028013101 @default.
• W4311652106 creator A5030597324 @default.
• W4311652106 creator A5035958047 @default.
• W4311652106 creator A5043007901 @default.
• W4311652106 creator A5043532920 @default.
• W4311652106 creator A5046308150 @default.
• W4311652106 creator A5049277365 @default.
• W4311652106 creator A5052899991 @default.
• W4311652106 creator A5061182355 @default.
• W4311652106 creator A5066599847 @default.
• W4311652106 creator A5081676218 @default.
• W4311652106 creator A5082066213 @default.
• W4311652106 creator A5085727632 @default.
• W4311652106 creator A5086528941 @default.
• W4311652106 creator A5088291390 @default.
• W4311652106 date "2022-12-06" @default.
• W4311652106 modified "2023-10-18" @default.
• W4311652106 title "RIPK3 Promotes Hantaviral Replication by Restricting JAK-STAT Signaling but not Triggering Necroptosis." @default.
• W4311652106 cites W1666433089 @default.
• W4311652106 cites W1820985142 @default.
• W4311652106 cites W1970822092 @default.
• W4311652106 cites W1973872887 @default.
• W4311652106 cites W1980321224 @default.
• W4311652106 cites W1986283558 @default.
• W4311652106 cites W1992573369 @default.
• W4311652106 cites W1993032029 @default.
• W4311652106 cites W2006273251 @default.
• W4311652106 cites W2014176574 @default.
• W4311652106 cites W2023122823 @default.
• W4311652106 cites W2033993387 @default.
• W4311652106 cites W2037151930 @default.
• W4311652106 cites W2050843600 @default.
• W4311652106 cites W2066196606 @default.
• W4311652106 cites W2092270470 @default.
• W4311652106 cites W2094279541 @default.
• W4311652106 cites W2094905665 @default.
• W4311652106 cites W2096259698 @default.
• W4311652106 cites W2107779325 @default.
• W4311652106 cites W2133402546 @default.
• W4311652106 cites W2139209512 @default.
• W4311652106 cites W2152021080 @default.
• W4311652106 cites W2152810785 @default.
• W4311652106 cites W2270042517 @default.
• W4311652106 cites W2570738774 @default.
• W4311652106 cites W2587820129 @default.
• W4311652106 cites W2601742683 @default.
• W4311652106 cites W2607501063 @default.
• W4311652106 cites W2611631307 @default.
• W4311652106 cites W2613027753 @default.
• W4311652106 cites W2659748313 @default.
• W4311652106 cites W2675105470 @default.
• W4311652106 cites W2783495890 @default.
• W4311652106 cites W2804802143 @default.
• W4311652106 cites W2890087043 @default.
• W4311652106 cites W2898336728 @default.
• W4311652106 cites W2902593728 @default.
• W4311652106 cites W2931678155 @default.
• W4311652106 cites W2944998017 @default.
• W4311652106 cites W2982017088 @default.
• W4311652106 cites W2996238888 @default.
• W4311652106 cites W3014027022 @default.
• W4311652106 cites W3047876262 @default.
• W4311652106 cites W3080649333 @default.
• W4311652106 cites W3110591293 @default.
• W4311652106 cites W3152941924 @default.
• W4311652106 cites W3160107858 @default.
• W4311652106 cites W3163276509 @default.
• W4311652106 cites W3186294780 @default.
• W4311652106 cites W3186425734 @default.
• W4311652106 cites W3200053343 @default.
• W4311652106 cites W3203623718 @default.
• W4311652106 cites W4210378872 @default.
• W4311652106 cites W4214848801 @default.
• W4311652106 cites W4281717942 @default.
• W4311652106 doi "https://doi.org/10.21203/rs.3.rs-2252467/v1" @default.
• W4311652106 hasPublicationYear "2022" @default.
• W4311652106 type Work @default.
• W4311652106 citedByCount "0" @default.
• W4311652106 crossrefType "posted-content" @default.
• W4311652106 hasAuthorship W4311652106A5022527850 @default.
• W4311652106 hasAuthorship W4311652106A5026089390 @default.
• W4311652106 hasAuthorship W4311652106A5028013101 @default.
• W4311652106 hasAuthorship W4311652106A5030597324 @default.
• W4311652106 hasAuthorship W4311652106A5035958047 @default.
• W4311652106 hasAuthorship W4311652106A5043007901 @default.
• W4311652106 hasAuthorship W4311652106A5043532920 @default.
• W4311652106 hasAuthorship W4311652106A5046308150 @default.
• W4311652106 hasAuthorship W4311652106A5049277365 @default.
• W4311652106 hasAuthorship W4311652106A5052899991 @default.
• W4311652106 hasAuthorship W4311652106A5061182355 @default.
• W4311652106 hasAuthorship W4311652106A5066599847 @default.
• W4311652106 hasAuthorship W4311652106A5081676218 @default.
• W4311652106 hasAuthorship W4311652106A5082066213 @default.
• W4311652106 hasAuthorship W4311652106A5085727632 @default.
• W4311652106 hasAuthorship W4311652106A5086528941 @default.
• W4311652106 hasAuthorship W4311652106A5088291390 @default.

• next