FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311662019> ?p ?o ?g. }

• W4311662019 endingPage "103400" @default.
• W4311662019 startingPage "103400" @default.
• W4311662019 abstract "Oxidative stress (OS) and neuroinflammatory pathways play an important role in the pathophysiology of schizophrenia. The present study investigated the relationship between OS, inflammatory cytokines, and clinical features in male patients with treatment-resistant schizophrenia (TRS).We measured plasma OS parameters, including manganese-superoxide dismutase (Mn-SOD), copper/zinc-containing SOD (CuZn-SOD), total-SOD (T-SOD), malondialdehyde (MDA), catalase (CAT), and glutathione peroxidase (GSH-Px); and serum inflammatory cytokines, including interleukin (IL)- 1α, IL-6, tumor necrosis factor-alpha (TNF-α), and interferon (IFN)-γ, from 80 male patients with chronic schizophrenia (31 had TRS and 49 had chronic stable schizophrenia (CSS)), and 42 healthy controls. The severity of psychotic symptoms was evaluated using the Positive and Negative Syndrome Scale (PANSS).Compared with healthy controls, plasma Mn-SOD, CuZn-SOD, T-SOD, GSH-Px, and MDA levels were significantly lower, while CAT and serum IL-6 levels were higher in both TRS and CSS male patients (all P < 0.05). Significant differences in the activities of CAT (F = 6.068, P = 0.016) and IL-6 levels (F = 6.876, P = 0.011) were observed between TRS and CSS male patients after analysis of covariance. Moreover, a significant positive correlation was found between IL-6 levels and PANSS general psychopathology subscores (r = 0.485, P = 0.006) and between CAT activity and PANSS total scores (r = 0.409, P = 0.022) in TRS male patients. CAT and IL-6 levels were predictors for TRS. Additionally, in chronic schizophrenia patients, a significant positive correlation was observed between IL-6 and GSH-Px (r = 0.292, P = 0.012), and the interaction effect of IL-6 and GSH-Px was positively associated with PANSS general psychopathology scores (r = 0.287, P = 0.014).This preliminary study indicated that variations in OS and inflammatory cytokines may be involved in psychopathology for patients with chronic schizophrenia, especially in male patients with TRS." @default.
• W4311662019 created "2022-12-27" @default.
• W4311662019 creator A5005005281 @default.
• W4311662019 creator A5011504657 @default.
• W4311662019 creator A5021430693 @default.
• W4311662019 creator A5038165954 @default.
• W4311662019 creator A5058073748 @default.
• W4311662019 creator A5070531600 @default.
• W4311662019 creator A5082298601 @default.
• W4311662019 date "2023-01-01" @default.
• W4311662019 modified "2023-10-14" @default.
• W4311662019 title "Catalase and interleukin-6 serum elevation in a prediction of treatment-resistance in male schizophrenia patients" @default.
• W4311662019 cites W1146519293 @default.
• W4311662019 cites W1253730247 @default.
• W4311662019 cites W1559088113 @default.
• W4311662019 cites W1976950210 @default.
• W4311662019 cites W1990417242 @default.
• W4311662019 cites W1990672905 @default.
• W4311662019 cites W1996955714 @default.
• W4311662019 cites W2009814577 @default.
• W4311662019 cites W2014109189 @default.
• W4311662019 cites W2017419668 @default.
• W4311662019 cites W2019956180 @default.
• W4311662019 cites W2029856455 @default.
• W4311662019 cites W2035859458 @default.
• W4311662019 cites W2038989423 @default.
• W4311662019 cites W2040909297 @default.
• W4311662019 cites W2047797335 @default.
• W4311662019 cites W2065494319 @default.
• W4311662019 cites W2082809298 @default.
• W4311662019 cites W2087484885 @default.
• W4311662019 cites W2105527159 @default.
• W4311662019 cites W2118742454 @default.
• W4311662019 cites W2135689380 @default.
• W4311662019 cites W2138714131 @default.
• W4311662019 cites W2142804847 @default.
• W4311662019 cites W2143325578 @default.
• W4311662019 cites W2158618087 @default.
• W4311662019 cites W2174335190 @default.
• W4311662019 cites W2210219816 @default.
• W4311662019 cites W2234053937 @default.
• W4311662019 cites W2558634429 @default.
• W4311662019 cites W2558879170 @default.
• W4311662019 cites W2560754155 @default.
• W4311662019 cites W2601087407 @default.
• W4311662019 cites W2750472899 @default.
• W4311662019 cites W2766233891 @default.
• W4311662019 cites W2801704870 @default.
• W4311662019 cites W2802931820 @default.
• W4311662019 cites W2806274450 @default.
• W4311662019 cites W2888923340 @default.
• W4311662019 cites W2889005116 @default.
• W4311662019 cites W2892238272 @default.
• W4311662019 cites W2896544938 @default.
• W4311662019 cites W2896691245 @default.
• W4311662019 cites W2902635231 @default.
• W4311662019 cites W2945575042 @default.
• W4311662019 cites W2956553143 @default.
• W4311662019 cites W2969616952 @default.
• W4311662019 cites W2982685163 @default.
• W4311662019 cites W2983514836 @default.
• W4311662019 cites W2984052120 @default.
• W4311662019 cites W2988195298 @default.
• W4311662019 cites W2989233097 @default.
• W4311662019 cites W2993797302 @default.
• W4311662019 cites W2998758116 @default.
• W4311662019 cites W2999966539 @default.
• W4311662019 cites W3004054511 @default.
• W4311662019 cites W3004064545 @default.
• W4311662019 cites W3014400703 @default.
• W4311662019 cites W3021167563 @default.
• W4311662019 cites W3033173266 @default.
• W4311662019 cites W3044253833 @default.
• W4311662019 cites W3047202359 @default.
• W4311662019 cites W3048384444 @default.
• W4311662019 cites W3083900586 @default.
• W4311662019 cites W3091977258 @default.
• W4311662019 cites W3094153337 @default.
• W4311662019 cites W3120693639 @default.
• W4311662019 cites W3121061938 @default.
• W4311662019 cites W3122208075 @default.
• W4311662019 cites W3137975801 @default.
• W4311662019 cites W3148228643 @default.
• W4311662019 cites W3163608549 @default.
• W4311662019 cites W3164864606 @default.
• W4311662019 cites W3196868658 @default.
• W4311662019 cites W3202141940 @default.
• W4311662019 cites W3216319414 @default.
• W4311662019 cites W4200270222 @default.
• W4311662019 cites W4205105460 @default.
• W4311662019 cites W4206254523 @default.
• W4311662019 cites W4210383558 @default.
• W4311662019 cites W4211025465 @default.
• W4311662019 doi "https://doi.org/10.1016/j.ajp.2022.103400" @default.
• W4311662019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36521406" @default.
• W4311662019 hasPublicationYear "2023" @default.
• W4311662019 type Work @default.
• W4311662019 citedByCount "1" @default.

• next