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- W4311662899 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a global health crisis after its emergence in 2019. Replication of the virus is initiated by binding of the viral spike (S) protein to human angiotensin-converting enzyme 2 (ACE2) on the target cell surface. Mutations acquired by SARS-CoV-2 S variants likely influence virus-target cell interaction. Here, using single-virus tracking to capture these initial steps, we observe how viruses carrying variant S interact with target cells. Specificity for ACE2 occurs for viruses with the reference sequence or D614G mutation. Analysis of the Alpha, Beta, and Delta SARS-CoV-2 variant S proteins revealed a progressive altered cell interaction with a reduced dependence on ACE2. Notably, the Delta variant S affinity was independent of ACE2. These enhanced interactions may account for the increased transmissibility of variants. Knowledge of how mutations influence cell interaction is essential for vaccine development against emerging variants of SARS-CoV-2." @default.
- W4311662899 created "2022-12-27" @default.
- W4311662899 creator A5004871354 @default.
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- W4311662899 date "2022-12-09" @default.
- W4311662899 modified "2023-10-01" @default.
- W4311662899 title "Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions" @default.
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- W4311662899 doi "https://doi.org/10.1126/sciadv.abo3977" @default.
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