Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311663899> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4311663899 endingPage "e0278823" @default.
- W4311663899 startingPage "e0278823" @default.
- W4311663899 abstract "Opioid-induced constipation (OIC) is one of the most common adverse events of opioid therapy and can severely reduce quality of life (QOL). Naldemedine is the orally available peripheral-acting μ-opioid receptor antagonist approved for OIC treatment. However in daily clinical practice, some cancer patients show insufficient control of OIC even while receiving naldemedine.To identify factors associated with non-response to naldemedine in cancer patients.This study retrospectively analyzed 127 cancer patients prescribed naldemedine at Seirei Hamamatsu General Hospital in Japan between November 2016 and June 2021. For the regression analysis of factors associated with OIC, variables were extracted manually from electronic medical records. Naldemedine had been prescribed by the attending physician after the presence of OIC had been defined with reference to Rome IV diagnostic criteria. Naldemedine was evaluated as effective in cases where the number of defecations increased at least once in the first 3 days after starting naldemedine. Multivariate logistic regression analysis was performed to identify factors associated with non-response to naldemedine. The data used were from the group of patients who received naldemedine in our previous study.Factors significantly associated with non-response to naldemedine included chemotherapy with taxanes within 1 month of evaluation of naldemedine effect (odds ratio [OR] = 0.063; 95% confidence interval [CI] = 0.007-0.568), and addition of or switching to naldemedine due to insufficient efficacy of prior laxatives (OR = 0.352, 95% CI = 0.129-0.966).The identification of factors associated with non-response to naldemedine prescribed for OIC may help improve QOL among cancer patients." @default.
- W4311663899 created "2022-12-27" @default.
- W4311663899 creator A5012907702 @default.
- W4311663899 creator A5026782265 @default.
- W4311663899 creator A5048563209 @default.
- W4311663899 creator A5051696209 @default.
- W4311663899 creator A5053712772 @default.
- W4311663899 creator A5084708258 @default.
- W4311663899 date "2022-12-09" @default.
- W4311663899 modified "2023-10-14" @default.
- W4311663899 title "Factors associated with non-response to naldemedine for opioid-induced constipation in cancer patients: A subgroup analysis" @default.
- W4311663899 cites W1481128086 @default.
- W4311663899 cites W1794052871 @default.
- W4311663899 cites W1978564033 @default.
- W4311663899 cites W2015009389 @default.
- W4311663899 cites W2037456262 @default.
- W4311663899 cites W2338484886 @default.
- W4311663899 cites W2344547018 @default.
- W4311663899 cites W2563316401 @default.
- W4311663899 cites W2610181166 @default.
- W4311663899 cites W2617664403 @default.
- W4311663899 cites W2763722121 @default.
- W4311663899 cites W2801854693 @default.
- W4311663899 cites W2884417868 @default.
- W4311663899 cites W2897071318 @default.
- W4311663899 cites W2897189621 @default.
- W4311663899 cites W2903959199 @default.
- W4311663899 cites W2905357805 @default.
- W4311663899 cites W2918522915 @default.
- W4311663899 cites W2958658309 @default.
- W4311663899 cites W2963662179 @default.
- W4311663899 cites W2973823229 @default.
- W4311663899 cites W2998466833 @default.
- W4311663899 cites W3006926865 @default.
- W4311663899 cites W3019463909 @default.
- W4311663899 cites W3019959385 @default.
- W4311663899 cites W3036652752 @default.
- W4311663899 cites W3156149930 @default.
- W4311663899 cites W3156415855 @default.
- W4311663899 cites W3179447472 @default.
- W4311663899 cites W4213018287 @default.
- W4311663899 cites W4224222867 @default.
- W4311663899 cites W4226324706 @default.
- W4311663899 doi "https://doi.org/10.1371/journal.pone.0278823" @default.
- W4311663899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36490241" @default.
- W4311663899 hasPublicationYear "2022" @default.
- W4311663899 type Work @default.
- W4311663899 citedByCount "1" @default.
- W4311663899 countsByYear W43116638992023 @default.
- W4311663899 crossrefType "journal-article" @default.
- W4311663899 hasAuthorship W4311663899A5012907702 @default.
- W4311663899 hasAuthorship W4311663899A5026782265 @default.
- W4311663899 hasAuthorship W4311663899A5048563209 @default.
- W4311663899 hasAuthorship W4311663899A5051696209 @default.
- W4311663899 hasAuthorship W4311663899A5053712772 @default.
- W4311663899 hasAuthorship W4311663899A5084708258 @default.
- W4311663899 hasBestOaLocation W43116638991 @default.
- W4311663899 hasConcept C126322002 @default.
- W4311663899 hasConcept C156957248 @default.
- W4311663899 hasConcept C197934379 @default.
- W4311663899 hasConcept C2781112942 @default.
- W4311663899 hasConcept C500440147 @default.
- W4311663899 hasConcept C71924100 @default.
- W4311663899 hasConcept C90924648 @default.
- W4311663899 hasConceptScore W4311663899C126322002 @default.
- W4311663899 hasConceptScore W4311663899C156957248 @default.
- W4311663899 hasConceptScore W4311663899C197934379 @default.
- W4311663899 hasConceptScore W4311663899C2781112942 @default.
- W4311663899 hasConceptScore W4311663899C500440147 @default.
- W4311663899 hasConceptScore W4311663899C71924100 @default.
- W4311663899 hasConceptScore W4311663899C90924648 @default.
- W4311663899 hasIssue "12" @default.
- W4311663899 hasLocation W43116638991 @default.
- W4311663899 hasLocation W43116638992 @default.
- W4311663899 hasLocation W43116638993 @default.
- W4311663899 hasLocation W43116638994 @default.
- W4311663899 hasOpenAccess W4311663899 @default.
- W4311663899 hasPrimaryLocation W43116638991 @default.
- W4311663899 hasRelatedWork W1984024463 @default.
- W4311663899 hasRelatedWork W2016948997 @default.
- W4311663899 hasRelatedWork W2162793463 @default.
- W4311663899 hasRelatedWork W2166613250 @default.
- W4311663899 hasRelatedWork W2317964258 @default.
- W4311663899 hasRelatedWork W2350429840 @default.
- W4311663899 hasRelatedWork W2380674154 @default.
- W4311663899 hasRelatedWork W2383281571 @default.
- W4311663899 hasRelatedWork W2606416030 @default.
- W4311663899 hasRelatedWork W2785990365 @default.
- W4311663899 hasVolume "17" @default.
- W4311663899 isParatext "false" @default.
- W4311663899 isRetracted "false" @default.
- W4311663899 workType "article" @default.