FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311664148> ?p ?o ?g. }

• W4311664148 endingPage "212" @default.
• W4311664148 startingPage "208" @default.
• W4311664148 abstract "Cholestasis is characterized by impaired bile flow which results in inflammation, cirrhosis, and ultimately liver failure. The current study is aimed to evaluate the anti-cholestatic effect of silymarin against α-naphthylisothiocyanate (ANIT) induced cholestasis. Mice were gavaged with various doses of silymarin or ursodeoxycholic acid (UDCA) for 19 days. Then they were challenged with α-naphthylisothiocyanate (ANIT) and after 48 hours the animals were sacrificed to obtain blood and liver sections. Serum levels of bilirubin, aspartate transaminase (AST), alanine transaminase (ALP), and liver histology were analyzed. mRNA expression of selected transporters (Bile salt export pump (BSEP) and sodium taurocholate cotransporting polypeptide (NTCP)) and proteins (farnesoid x receptor (FXR) and Cytochrome P450 Family 7 Subfamily A Member 1 (Cyp7a1)) involved in bile acids biosynthesis, excretion and uptake were also evaluated by quantitative PCR. The results indicated that the serum levels of bilirubin, AST, and ALP were significantly higher in a cholestatic model group as compared to an untreated control group. However, in silymarin groups, the serum level of these parameters is significantly lower than in a cholestatic model group. Liver histology also showed that silymarin prevents ANIT-induced hepatic injury. mRNA expression of FXR, BSEP, and NTCP was downregulated and expression of Cyp7a1 was upregulated in a cholestatic model group as compared to an untreated control group. However, in silymarin treatment groups, the expression of FXR, BSEP and NTCP was upregulated and the expression of Cyp7a1 was downregulated as compared to the cholestatic model group. In conclusion, silymarin could alleviate hepatic injury by modulating the expression of genes involved in bile acid homeostasis." @default.
• W4311664148 created "2022-12-27" @default.
• W4311664148 creator A5015446047 @default.
• W4311664148 creator A5020532199 @default.
• W4311664148 creator A5054471551 @default.
• W4311664148 creator A5057027395 @default.
• W4311664148 creator A5057686100 @default.
• W4311664148 creator A5074619520 @default.
• W4311664148 date "2022-07-31" @default.
• W4311664148 modified "2023-10-01" @default.
• W4311664148 title "Silymarin protects the liver from α-naphthylisothiocyanate-induced cholestasis by modulating the expression of genes involved in bile acid homeostasis" @default.
• W4311664148 doi "https://doi.org/10.14715/cmb/2022.68.7.34" @default.
• W4311664148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36495494" @default.
• W4311664148 hasPublicationYear "2022" @default.
• W4311664148 type Work @default.
• W4311664148 citedByCount "1" @default.
• W4311664148 countsByYear W43116641482023 @default.
• W4311664148 crossrefType "journal-article" @default.
• W4311664148 hasAuthorship W4311664148A5015446047 @default.
• W4311664148 hasAuthorship W4311664148A5020532199 @default.
• W4311664148 hasAuthorship W4311664148A5054471551 @default.
• W4311664148 hasAuthorship W4311664148A5057027395 @default.
• W4311664148 hasAuthorship W4311664148A5057686100 @default.
• W4311664148 hasAuthorship W4311664148A5074619520 @default.
• W4311664148 hasBestOaLocation W43116641481 @default.
• W4311664148 hasConcept C10213722 @default.
• W4311664148 hasConcept C104317684 @default.
• W4311664148 hasConcept C126322002 @default.
• W4311664148 hasConcept C127561419 @default.
• W4311664148 hasConcept C134018914 @default.
• W4311664148 hasConcept C149011108 @default.
• W4311664148 hasConcept C160160445 @default.
• W4311664148 hasConcept C170493617 @default.
• W4311664148 hasConcept C181199279 @default.
• W4311664148 hasConcept C185592680 @default.
• W4311664148 hasConcept C203862802 @default.
• W4311664148 hasConcept C2775936931 @default.
• W4311664148 hasConcept C2776637226 @default.
• W4311664148 hasConcept C2777513400 @default.
• W4311664148 hasConcept C2778593092 @default.
• W4311664148 hasConcept C2778606649 @default.
• W4311664148 hasConcept C2779399885 @default.
• W4311664148 hasConcept C2779679107 @default.
• W4311664148 hasConcept C2780965833 @default.
• W4311664148 hasConcept C2910800957 @default.
• W4311664148 hasConcept C36201501 @default.
• W4311664148 hasConcept C44312359 @default.
• W4311664148 hasConcept C55493867 @default.
• W4311664148 hasConcept C63932345 @default.
• W4311664148 hasConcept C71924100 @default.
• W4311664148 hasConcept C74373430 @default.
• W4311664148 hasConcept C86339819 @default.
• W4311664148 hasConcept C89673097 @default.
• W4311664148 hasConceptScore W4311664148C10213722 @default.
• W4311664148 hasConceptScore W4311664148C104317684 @default.
• W4311664148 hasConceptScore W4311664148C126322002 @default.
• W4311664148 hasConceptScore W4311664148C127561419 @default.
• W4311664148 hasConceptScore W4311664148C134018914 @default.
• W4311664148 hasConceptScore W4311664148C149011108 @default.
• W4311664148 hasConceptScore W4311664148C160160445 @default.
• W4311664148 hasConceptScore W4311664148C170493617 @default.
• W4311664148 hasConceptScore W4311664148C181199279 @default.
• W4311664148 hasConceptScore W4311664148C185592680 @default.
• W4311664148 hasConceptScore W4311664148C203862802 @default.
• W4311664148 hasConceptScore W4311664148C2775936931 @default.
• W4311664148 hasConceptScore W4311664148C2776637226 @default.
• W4311664148 hasConceptScore W4311664148C2777513400 @default.
• W4311664148 hasConceptScore W4311664148C2778593092 @default.
• W4311664148 hasConceptScore W4311664148C2778606649 @default.
• W4311664148 hasConceptScore W4311664148C2779399885 @default.
• W4311664148 hasConceptScore W4311664148C2779679107 @default.
• W4311664148 hasConceptScore W4311664148C2780965833 @default.
• W4311664148 hasConceptScore W4311664148C2910800957 @default.
• W4311664148 hasConceptScore W4311664148C36201501 @default.
• W4311664148 hasConceptScore W4311664148C44312359 @default.
• W4311664148 hasConceptScore W4311664148C55493867 @default.
• W4311664148 hasConceptScore W4311664148C63932345 @default.
• W4311664148 hasConceptScore W4311664148C71924100 @default.
• W4311664148 hasConceptScore W4311664148C74373430 @default.
• W4311664148 hasConceptScore W4311664148C86339819 @default.
• W4311664148 hasConceptScore W4311664148C89673097 @default.
• W4311664148 hasIssue "7" @default.
• W4311664148 hasLocation W43116641481 @default.
• W4311664148 hasLocation W43116641482 @default.
• W4311664148 hasOpenAccess W4311664148 @default.
• W4311664148 hasPrimaryLocation W43116641481 @default.
• W4311664148 hasRelatedWork W1987784816 @default.
• W4311664148 hasRelatedWork W2028908767 @default.
• W4311664148 hasRelatedWork W2089950370 @default.
• W4311664148 hasRelatedWork W2102434679 @default.
• W4311664148 hasRelatedWork W2162200550 @default.
• W4311664148 hasRelatedWork W2791938916 @default.
• W4311664148 hasRelatedWork W2995732359 @default.
• W4311664148 hasRelatedWork W3172816816 @default.
• W4311664148 hasRelatedWork W4280490778 @default.
• W4311664148 hasRelatedWork W4311664148 @default.
• W4311664148 hasVolume "68" @default.
• W4311664148 isParatext "false" @default.

• next