Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311664554> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4311664554 endingPage "543" @default.
- W4311664554 startingPage "539" @default.
- W4311664554 abstract "Although estimates of the prevalence of cardiac arrhythmias in healthy volunteers exist, there is a lack of baseline data in other specific populations, such as people living with overweight and obesity, who are increasingly involved in clinical trials. This study investigated the baseline prevalence of arrhythmias in participants with overweight or obesity in 2 phase 1 trials of weight management medications (NCT03661879, NCT03308721). Participants aged 18-55 years, without a history of cardiovascular disease, and with body mass index (BMI) of 25.0-39.9 kg/m2 , were screened for abnormalities in vital signs, electrocardiogram (ECG) recordings, and electrolytes. Baseline 24-hour ECG (Holter) data were collected and manually reviewed by a cardiologist. The primary endpoint was the proportion of participants with ≥1 episode of the predefined cardiac arrhythmias. Continuous 12-lead ECG data were obtained from 207 participants. Most arrhythmias occurred in <3% of participants. Atrioventricular blocks and other potentially malignant arrhythmias were uncommon. There were no associations with age, sex, or BMI. Prevalence of atrioventricular blocks, nonsustained ventricular tachycardia, and other potentially malignant arrhythmias mirrored those reported in healthy participants with normal weight. In clinical trials of weight management medication, knowledge of the baseline prevalence of arrhythmias in people with overweight and obesity may inform trial eligibility criteria, improve on-trial decisions, and could be useful in discussions with health authorities. Baseline Holter readings and real-time ECG telemetry monitoring should be considered in such trials if arrhythmia risk is intrinsic to the molecule, or when signals have been observed in preclinical studies." @default.
- W4311664554 created "2022-12-27" @default.
- W4311664554 creator A5002882004 @default.
- W4311664554 creator A5018535962 @default.
- W4311664554 creator A5025369867 @default.
- W4311664554 creator A5029901911 @default.
- W4311664554 creator A5039269787 @default.
- W4311664554 creator A5055673082 @default.
- W4311664554 creator A5077717495 @default.
- W4311664554 creator A5085348099 @default.
- W4311664554 creator A5088864688 @default.
- W4311664554 date "2023-01-20" @default.
- W4311664554 modified "2023-09-26" @default.
- W4311664554 title "Prevalence of Baseline Cardiac Arrhythmias in Participants with Overweight or Obesity in Phase 1 Clinical Trials: Analysis of 24‐Hour Holter Electrocardiogram Recordings" @default.
- W4311664554 cites W1973410958 @default.
- W4311664554 cites W1990267183 @default.
- W4311664554 cites W2058761320 @default.
- W4311664554 cites W2062336203 @default.
- W4311664554 cites W2062461639 @default.
- W4311664554 cites W2095345961 @default.
- W4311664554 cites W2114212037 @default.
- W4311664554 cites W2119375148 @default.
- W4311664554 cites W2134362869 @default.
- W4311664554 cites W2168111687 @default.
- W4311664554 cites W2183751423 @default.
- W4311664554 cites W2283475911 @default.
- W4311664554 cites W2288617387 @default.
- W4311664554 cites W2538559610 @default.
- W4311664554 cites W2888628330 @default.
- W4311664554 cites W4317639815 @default.
- W4311664554 doi "https://doi.org/10.1002/jcph.2193" @default.
- W4311664554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36524539" @default.
- W4311664554 hasPublicationYear "2023" @default.
- W4311664554 type Work @default.
- W4311664554 citedByCount "0" @default.
- W4311664554 crossrefType "journal-article" @default.
- W4311664554 hasAuthorship W4311664554A5002882004 @default.
- W4311664554 hasAuthorship W4311664554A5018535962 @default.
- W4311664554 hasAuthorship W4311664554A5025369867 @default.
- W4311664554 hasAuthorship W4311664554A5029901911 @default.
- W4311664554 hasAuthorship W4311664554A5039269787 @default.
- W4311664554 hasAuthorship W4311664554A5055673082 @default.
- W4311664554 hasAuthorship W4311664554A5077717495 @default.
- W4311664554 hasAuthorship W4311664554A5085348099 @default.
- W4311664554 hasAuthorship W4311664554A5088864688 @default.
- W4311664554 hasBestOaLocation W43116645541 @default.
- W4311664554 hasConcept C126322002 @default.
- W4311664554 hasConcept C164705383 @default.
- W4311664554 hasConcept C1862650 @default.
- W4311664554 hasConcept C203092338 @default.
- W4311664554 hasConcept C2776331378 @default.
- W4311664554 hasConcept C2779812945 @default.
- W4311664554 hasConcept C2780040984 @default.
- W4311664554 hasConcept C2780221984 @default.
- W4311664554 hasConcept C2780283014 @default.
- W4311664554 hasConcept C2780586474 @default.
- W4311664554 hasConcept C511355011 @default.
- W4311664554 hasConcept C535046627 @default.
- W4311664554 hasConcept C71924100 @default.
- W4311664554 hasConceptScore W4311664554C126322002 @default.
- W4311664554 hasConceptScore W4311664554C164705383 @default.
- W4311664554 hasConceptScore W4311664554C1862650 @default.
- W4311664554 hasConceptScore W4311664554C203092338 @default.
- W4311664554 hasConceptScore W4311664554C2776331378 @default.
- W4311664554 hasConceptScore W4311664554C2779812945 @default.
- W4311664554 hasConceptScore W4311664554C2780040984 @default.
- W4311664554 hasConceptScore W4311664554C2780221984 @default.
- W4311664554 hasConceptScore W4311664554C2780283014 @default.
- W4311664554 hasConceptScore W4311664554C2780586474 @default.
- W4311664554 hasConceptScore W4311664554C511355011 @default.
- W4311664554 hasConceptScore W4311664554C535046627 @default.
- W4311664554 hasConceptScore W4311664554C71924100 @default.
- W4311664554 hasIssue "5" @default.
- W4311664554 hasLocation W43116645541 @default.
- W4311664554 hasLocation W43116645542 @default.
- W4311664554 hasOpenAccess W4311664554 @default.
- W4311664554 hasPrimaryLocation W43116645541 @default.
- W4311664554 hasRelatedWork W1866091461 @default.
- W4311664554 hasRelatedWork W2000335303 @default.
- W4311664554 hasRelatedWork W2022378324 @default.
- W4311664554 hasRelatedWork W2047277250 @default.
- W4311664554 hasRelatedWork W2363570094 @default.
- W4311664554 hasRelatedWork W2403825624 @default.
- W4311664554 hasRelatedWork W2625095604 @default.
- W4311664554 hasRelatedWork W2777447650 @default.
- W4311664554 hasRelatedWork W4380150467 @default.
- W4311664554 hasRelatedWork W8959992 @default.
- W4311664554 hasVolume "63" @default.
- W4311664554 isParatext "false" @default.
- W4311664554 isRetracted "false" @default.
- W4311664554 workType "article" @default.