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- W4311671161 endingPage "15423" @default.
- W4311671161 startingPage "15423" @default.
- W4311671161 abstract "The role of exogenous microRNAs (miRNAs) in renal fibrosis is poorly understood. Here, the effect of exogenous miRNAs on renal fibrosis was investigated using a renal fibrosis mouse model generated by unilateral ureteral obstruction (UUO). miRNA microarray analysis and quantitative reverse-transcription polymerase chain reaction showed that miR-122-5p was the most downregulated (0.28-fold) miRNA in the kidneys of UUO mice. The injection of an miR-122-5p mimic promoted renal fibrosis and upregulated COL1A2 and FN1, whereas an miR-122-5p inhibitor suppressed renal fibrosis and downregulated COL1A2 and FN1. The expression levels of fibrosis-related mRNAs, which were predicted targets of miR-122-5p, were evaluated. The expression level of TGFBR2, a pro-fibrotic mRNA, was upregulated by the miR-122-5p mimic, and the expression level of FOXO3, an anti-fibrotic mRNA, was upregulated by the miR-122-5p inhibitor. The protein expressions of TGFBR2 and FOXO3 were confirmed by immunohistochemistry. Additionally, the expression levels of LC3, downstream anti-fibrotic mRNAs of FOXO3, were upregulated by the miR-122-5p inhibitor. These results suggest that miR-122-5p has critical roles in renal fibrosis." @default.
- W4311671161 created "2022-12-28" @default.
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- W4311671161 date "2022-12-06" @default.
- W4311671161 modified "2023-10-18" @default.
- W4311671161 title "miR−122−5p Regulates Renal Fibrosis In Vivo" @default.
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- W4311671161 doi "https://doi.org/10.3390/ijms232315423" @default.
- W4311671161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36499744" @default.
- W4311671161 hasPublicationYear "2022" @default.
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