Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311671657> ?p ?o ?g. }
- W4311671657 endingPage "160646" @default.
- W4311671657 startingPage "160646" @default.
- W4311671657 abstract "Plastic pollution is recognized as a major threat to ecosystems in the 21st century. Large plastic objects undergo biotic and abiotic degradation to generate micro- and nano-sized plastic pieces. Despite tremendous efforts to evaluate the adverse effects of microplastics, a comprehensive understanding of the toxicity of nanoplastics remains elusive, especially at the protein level. To this end, we used isobaric-tag-for-relative-and-absolute-quantitation-based quantitative proteomics to investigate the proteome dynamics of the soil nematode Caenorhabditis elegans in response to exposure to 100 nm polystyrene nanoplastics (PS-NPs). After 48 h of exposure to 0.1, 1, or 10 mg/L PS-NPs, 136 out of 1684 proteins were differentially expressed and 108 of these proteins were upregulated. These proteins were related to ribosome biogenesis, translation, proteolysis, kinases, protein processing in the endoplasmic reticulum, and energy metabolism. Remarkably, changes in proteome dynamics in response to exposure to PS-NPs were consistent with the phenotypic defects of C. elegans. Collectively, our findings demonstrate that disruption of proteome homeostasis is a biological consequence of PS-NPs accumulation in C. elegans, which provides insights into the molecular mechanisms underlying the toxicology of nanoplastics." @default.
- W4311671657 created "2022-12-28" @default.
- W4311671657 creator A5013822680 @default.
- W4311671657 creator A5025336901 @default.
- W4311671657 creator A5030101186 @default.
- W4311671657 creator A5033328883 @default.
- W4311671657 creator A5046597133 @default.
- W4311671657 creator A5068255173 @default.
- W4311671657 creator A5068414824 @default.
- W4311671657 creator A5070833857 @default.
- W4311671657 creator A5078209437 @default.
- W4311671657 creator A5086174140 @default.
- W4311671657 date "2023-03-01" @default.
- W4311671657 modified "2023-10-13" @default.
- W4311671657 title "Evaluation of nanoplastics toxicity in the soil nematode Caenorhabditis elegans by iTRAQ-based quantitative proteomics" @default.
- W4311671657 cites W1489479425 @default.
- W4311671657 cites W1758551139 @default.
- W4311671657 cites W1861035294 @default.
- W4311671657 cites W1973592885 @default.
- W4311671657 cites W1986320836 @default.
- W4311671657 cites W2001003549 @default.
- W4311671657 cites W2002741326 @default.
- W4311671657 cites W2013303176 @default.
- W4311671657 cites W2021916606 @default.
- W4311671657 cites W2026463310 @default.
- W4311671657 cites W2037496050 @default.
- W4311671657 cites W2038621827 @default.
- W4311671657 cites W2064390078 @default.
- W4311671657 cites W2072020790 @default.
- W4311671657 cites W2074372206 @default.
- W4311671657 cites W2076053153 @default.
- W4311671657 cites W2084801699 @default.
- W4311671657 cites W2086691574 @default.
- W4311671657 cites W2092691099 @default.
- W4311671657 cites W2113570557 @default.
- W4311671657 cites W2119630070 @default.
- W4311671657 cites W2135983637 @default.
- W4311671657 cites W2147300658 @default.
- W4311671657 cites W2154465060 @default.
- W4311671657 cites W2157147131 @default.
- W4311671657 cites W2162515865 @default.
- W4311671657 cites W2224940506 @default.
- W4311671657 cites W2269367120 @default.
- W4311671657 cites W2334665931 @default.
- W4311671657 cites W2337621927 @default.
- W4311671657 cites W2462387182 @default.
- W4311671657 cites W2472587950 @default.
- W4311671657 cites W2491339641 @default.
- W4311671657 cites W2622663150 @default.
- W4311671657 cites W2782356235 @default.
- W4311671657 cites W2785715629 @default.
- W4311671657 cites W2789805207 @default.
- W4311671657 cites W2790379409 @default.
- W4311671657 cites W2796427113 @default.
- W4311671657 cites W2901747639 @default.
- W4311671657 cites W2904524823 @default.
- W4311671657 cites W2911948850 @default.
- W4311671657 cites W2946333424 @default.
- W4311671657 cites W2949343582 @default.
- W4311671657 cites W2951903539 @default.
- W4311671657 cites W2964417610 @default.
- W4311671657 cites W2992692303 @default.
- W4311671657 cites W3007155206 @default.
- W4311671657 cites W3007886688 @default.
- W4311671657 cites W3025632860 @default.
- W4311671657 cites W3030324325 @default.
- W4311671657 cites W3103639032 @default.
- W4311671657 cites W3107527779 @default.
- W4311671657 cites W3114399463 @default.
- W4311671657 cites W3115412306 @default.
- W4311671657 cites W3115665917 @default.
- W4311671657 cites W3122119529 @default.
- W4311671657 cites W3124536682 @default.
- W4311671657 cites W3142924439 @default.
- W4311671657 cites W3158134693 @default.
- W4311671657 cites W3181645590 @default.
- W4311671657 cites W3199846221 @default.
- W4311671657 cites W3215752507 @default.
- W4311671657 cites W4220722374 @default.
- W4311671657 cites W4282968406 @default.
- W4311671657 cites W4293104570 @default.
- W4311671657 cites W4293768856 @default.
- W4311671657 cites W4295788644 @default.
- W4311671657 cites W69618629 @default.
- W4311671657 doi "https://doi.org/10.1016/j.scitotenv.2022.160646" @default.
- W4311671657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36493839" @default.
- W4311671657 hasPublicationYear "2023" @default.
- W4311671657 type Work @default.
- W4311671657 citedByCount "5" @default.
- W4311671657 countsByYear W43116716572023 @default.
- W4311671657 crossrefType "journal-article" @default.
- W4311671657 hasAuthorship W4311671657A5013822680 @default.
- W4311671657 hasAuthorship W4311671657A5025336901 @default.
- W4311671657 hasAuthorship W4311671657A5030101186 @default.
- W4311671657 hasAuthorship W4311671657A5033328883 @default.
- W4311671657 hasAuthorship W4311671657A5046597133 @default.
- W4311671657 hasAuthorship W4311671657A5068255173 @default.
- W4311671657 hasAuthorship W4311671657A5068414824 @default.