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- W4311674988 abstract "Most people with von Willebrand disease (VWD) have a partial quantitative deficiency of plasma von Willebrand factor (VWF) or type 1 VWD. In contrast to type 2 and type 3 VWD, laboratory assays will not always establish the diagnosis in type 1 VWD. This is because plasma VWF levels in type 1 VWD, especially those with levels closer to 50 IU/dL, overlap with the general population. Assessment is further complicated by increased plasma VWF levels in response to physiologic stressors or aging. Diagnosis of those with type 1 VWD with plasma VWF levels 30 to 50 IU/dL (previously referred to as low VWF) requires expert assessment of bleeding phenotype as well as an understanding of the limitations of both bleeding assessment tools (BATs) and laboratory testing. Using the available evidence and highlighting research gaps, we discuss common dilemmas facing providers relating to assessment of adolescents, transition from pediatrics to adult care, and older individuals with type 1 VWD." @default.
- W4311674988 created "2022-12-28" @default.
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- W4311674988 date "2022-12-09" @default.
- W4311674988 modified "2023-09-27" @default.
- W4311674988 title "Diagnostic pitfalls and conundrums in type 1 von Willebrand disease" @default.
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- W4311674988 doi "https://doi.org/10.1182/hematology.2022000389" @default.
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