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- W4311679975 abstract "We read with interest the results of the MAPLE trial showing additional suppression by prednisolone of FeNO, blood, and sputum eosinophils in patients taking mepolizumab.1 These findings illustrate the limited impact of mepolizumab on type 2 inflammation with regard to persistent IL4/IL13 escape in the presence of IL5 blockade.2 As such, this reinforces the importance of carefully observing type 2 biomarkers in patients treated with mepolizumab and considering other biologics that have more broad-spectrum effects in suppressing the type 2 inflammatory phenotype." @default.
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- W4311679975 date "2022-12-01" @default.
- W4311679975 modified "2023-09-24" @default.
- W4311679975 title "Partial suppression of type 2 inflammation with mepolizumab" @default.
- W4311679975 cites W4210272860 @default.
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- W4311679975 doi "https://doi.org/10.1016/j.jaip.2022.08.053" @default.
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