Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311681489> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4311681489 abstract "Abstract Zoonotic cutaneous leishmaniasis caused by Leishmania major is the most common type of disease in Iran. Conventional anticoagulants have been used in the treatment of cutaneous leishmaniasis for a long time, but drug resistance and some serious side effects have been reported. Therefore, the discovery and development of new therapeutic candidates is needed. Peptide CM11 is one of these peptides whose antibacterial activity has been proven. This peptide is a short cecropin-melittin hybrid peptide obtained through a hybrid sequencing method. The aim of this study is to evaluate the anti-leishmanial activity of CM11 platelets against amastigote forms of Leishmania major. In this research, amastigote forms of Iranian garlic L. major (MRHO / IR / 75 / ER) were cultured in the presence of different molar concentrations of methylantimony (glucanthium) to find the most suitable concentration of glucanthium in comparison with L. major amastigotes, then the anti-leishmania activity Different concentrations of CM11 peptide (8, 16, 32 and 64 µM) for 24, 48 and 72 hours were examined by DAPI staining. In addition, MTT was used to determine the cytotoxic effects of CM11 peptide on mouse fibroblast cells. The results showed that CM11 peptide has an antimicrobial effect against the Iranian isolate of L. major in laboratory conditions. CM11 peptide seems to have significant potential as a new anti-leishmanial agent." @default.
- W4311681489 created "2022-12-28" @default.
- W4311681489 creator A5003795980 @default.
- W4311681489 date "2022-12-16" @default.
- W4311681489 modified "2023-09-27" @default.
- W4311681489 title "Investigation of antimicrobial peptide activity against amastigote forms of Leishmania major" @default.
- W4311681489 cites W1577113681 @default.
- W4311681489 cites W1969745695 @default.
- W4311681489 cites W1978525080 @default.
- W4311681489 cites W1997152791 @default.
- W4311681489 cites W1997231586 @default.
- W4311681489 cites W2011615074 @default.
- W4311681489 cites W2024410063 @default.
- W4311681489 cites W2053132846 @default.
- W4311681489 cites W2054743571 @default.
- W4311681489 cites W2055791407 @default.
- W4311681489 cites W2057580255 @default.
- W4311681489 cites W2058656891 @default.
- W4311681489 cites W2066954635 @default.
- W4311681489 cites W2067546903 @default.
- W4311681489 cites W2069913623 @default.
- W4311681489 cites W2074505948 @default.
- W4311681489 cites W2075370926 @default.
- W4311681489 cites W2113617378 @default.
- W4311681489 cites W2118361133 @default.
- W4311681489 cites W2119678650 @default.
- W4311681489 cites W2127277747 @default.
- W4311681489 cites W2134403063 @default.
- W4311681489 cites W2142224224 @default.
- W4311681489 cites W2142656313 @default.
- W4311681489 cites W2170956456 @default.
- W4311681489 cites W2318591953 @default.
- W4311681489 cites W2492622187 @default.
- W4311681489 cites W2736103680 @default.
- W4311681489 cites W2783981376 @default.
- W4311681489 cites W3147310958 @default.
- W4311681489 doi "https://doi.org/10.21203/rs.3.rs-2382504/v1" @default.
- W4311681489 hasPublicationYear "2022" @default.
- W4311681489 type Work @default.
- W4311681489 citedByCount "0" @default.
- W4311681489 crossrefType "posted-content" @default.
- W4311681489 hasAuthorship W4311681489A5003795980 @default.
- W4311681489 hasBestOaLocation W43116814891 @default.
- W4311681489 hasConcept C136764020 @default.
- W4311681489 hasConcept C185592680 @default.
- W4311681489 hasConcept C202751555 @default.
- W4311681489 hasConcept C203014093 @default.
- W4311681489 hasConcept C2776555147 @default.
- W4311681489 hasConcept C2778702967 @default.
- W4311681489 hasConcept C2779281246 @default.
- W4311681489 hasConcept C2780599195 @default.
- W4311681489 hasConcept C2780783641 @default.
- W4311681489 hasConcept C2781092759 @default.
- W4311681489 hasConcept C41008148 @default.
- W4311681489 hasConcept C4937899 @default.
- W4311681489 hasConcept C540938839 @default.
- W4311681489 hasConcept C55493867 @default.
- W4311681489 hasConcept C71928629 @default.
- W4311681489 hasConcept C86803240 @default.
- W4311681489 hasConcept C89423630 @default.
- W4311681489 hasConcept C98274493 @default.
- W4311681489 hasConcept C98319499 @default.
- W4311681489 hasConceptScore W4311681489C136764020 @default.
- W4311681489 hasConceptScore W4311681489C185592680 @default.
- W4311681489 hasConceptScore W4311681489C202751555 @default.
- W4311681489 hasConceptScore W4311681489C203014093 @default.
- W4311681489 hasConceptScore W4311681489C2776555147 @default.
- W4311681489 hasConceptScore W4311681489C2778702967 @default.
- W4311681489 hasConceptScore W4311681489C2779281246 @default.
- W4311681489 hasConceptScore W4311681489C2780599195 @default.
- W4311681489 hasConceptScore W4311681489C2780783641 @default.
- W4311681489 hasConceptScore W4311681489C2781092759 @default.
- W4311681489 hasConceptScore W4311681489C41008148 @default.
- W4311681489 hasConceptScore W4311681489C4937899 @default.
- W4311681489 hasConceptScore W4311681489C540938839 @default.
- W4311681489 hasConceptScore W4311681489C55493867 @default.
- W4311681489 hasConceptScore W4311681489C71928629 @default.
- W4311681489 hasConceptScore W4311681489C86803240 @default.
- W4311681489 hasConceptScore W4311681489C89423630 @default.
- W4311681489 hasConceptScore W4311681489C98274493 @default.
- W4311681489 hasConceptScore W4311681489C98319499 @default.
- W4311681489 hasLocation W43116814891 @default.
- W4311681489 hasOpenAccess W4311681489 @default.
- W4311681489 hasPrimaryLocation W43116814891 @default.
- W4311681489 hasRelatedWork W2041644651 @default.
- W4311681489 hasRelatedWork W2103928203 @default.
- W4311681489 hasRelatedWork W2123798969 @default.
- W4311681489 hasRelatedWork W2163231569 @default.
- W4311681489 hasRelatedWork W2790526432 @default.
- W4311681489 hasRelatedWork W2903412769 @default.
- W4311681489 hasRelatedWork W2907130457 @default.
- W4311681489 hasRelatedWork W3021207022 @default.
- W4311681489 hasRelatedWork W3110109783 @default.
- W4311681489 hasRelatedWork W4311681489 @default.
- W4311681489 isParatext "false" @default.
- W4311681489 isRetracted "false" @default.
- W4311681489 workType "article" @default.