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- W4311698190 abstract "<h3>Background</h3> There is an increasing urgency for healthcare professionals to also consider the environmental impact when making decisions on care. For inhaled therapies, pressurized metered dose inhalers (pMDI) have a 20–40-fold greater carbon footprint compared to dry powder inhalers (DPI), which make them a significantly more sustainable form of treatment. However, there is a persistent concern among clinicians whether patients with advanced COPD can generate sufficient inspiratory effort to use DPIs successfully to ensure effective and consistent inhaler therapy. <h3>Methods</h3> Pooled data of 246 patients (34.6% female, mean age 66.8 years and FEV1 1.5l) with COPD from previous clinical trials were analysed to identify possible predictors of peak inspiratory flow rate (PIF) via the DPI Easyhaler (PIF<sub>EH</sub>) and to assess the proportion of patients able to achieve a PIF<sub>EH</sub> of 30 L/min, which is needed to use the Easyhaler successfully. <h3>Results</h3> The mean PIF<sub>EH</sub> was 56.9 L/min and 99% (243/246) of the study patients achieved sufficient PIF levels. In the statistical modelling, none of the analysed patient characteristics (age, gender and BMI) or expiratory spirometry values predicted PIF<sub>EH</sub> significantly and the model accounted only for 18% of the observed variation in PIF<sub>EH</sub>. <h3>Conclusions</h3> Based on our results, impaired expiratory lung function or patient characteristics do not predict patient’s ability to efficiently use Easyhaler DPI in COPD. 99% of the patients succeeded in generating sufficient inspiratory effort for correct dose delivery from the Easyhaler. Considering the targets set for sustainability in healthcare, this topic should be addressed in the clinics as DPIs are a valid alternative for most patients when choosing the best inhaler for each individual patient." @default.
- W4311698190 created "2022-12-28" @default.
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- W4311698190 date "2022-11-01" @default.
- W4311698190 modified "2023-10-17" @default.
- W4311698190 title "P183 COPD patients are able to use DPI successfully, regardless of age and severity of airflow limitation" @default.
- W4311698190 doi "https://doi.org/10.1136/thorax-2022-btsabstracts.317" @default.
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