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• W4311698344 abstract "<h3>Introduction</h3> Cough is a common symptom in patients with interstitial lung disease. Studies have previously focused on the burden of cough in idiopathic pulmonary fibrosis (IPF) and research is lacking in patients with hypersensitivity pneumonitis (HP). We aimed to investigate reported cough severity in subjects with HP, using an IPF cohort as disease controls. <h3>Methods</h3> We recruited incident cases of IPF and HP into a prospective observational study. Cough visual analogue scales (VAS, range 0–100 mm) and Leicester Cough Questionnaires (LCQ, range 3–21) were collected at baseline. Demographic details, lung function and bronchoalveolar lavage (BAL) cell differentials were collected. <h3>Results</h3> A total of 207 IPF and 35 HP patients were recruited. Demographic data is summarised in table 1. All subjects with IPF had never received antifibrotic therapy. Only 6/35 patients with HP had received prior steroid treatment. Median cough VAS was 29 mm in IPF and 29.5 mm in HP (Mann-Whitney U, <i>p</i> = 0.732). Median LCQ was 16.1 in IPF and 15.1 in HP (Mann-Whitney U, <i>p</i> = 0.138). FVC and TLco negatively correlated with cough VAS in both IPF and HP subgroups. While TLco positively correlated with LCQ in IPF, neither lung function parameters derived correlation with LCQ in HP. BAL percentage lymphocyte fraction was available for 46 IPF and 28 HP patients (mean 11.2% and 33.2% respectively). In the cohort as a whole an elevated BAL lymphocyte count was associated with higher cough VAS (<i>r</i> = 0.313; p = 0.007). To establish independent predictors of cough within our combined cohort a general linear model analysis was conducted for cough VAS and LCQ. The variables assessed in this model included smoking history, age, sex, reflux, FVC and TLco. FVC (p = 0.002) and sex (p = 0.049) were predictive of cough VAS. However, none of the independent variables were predictive of LCQ. <h3>Conclusion</h3> Cough burden in HP is similar to IPF, with poorer FVC seemingly a factor in predicting reported cough severity. The association between BAL lymphocytosis and cough VAS support the theory that inflammation is linked to cough." @default.
• W4311698344 created "2022-12-28" @default.
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• W4311698344 date "2022-11-01" @default.
• W4311698344 modified "2023-09-28" @default.
• W4311698344 title "S3 Characterising cough burden in hypersensitivity pneumonitis" @default.
• W4311698344 doi "https://doi.org/10.1136/thorax-2022-btsabstracts.9" @default.
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