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- W4311698899 abstract "<h3>Introduction</h3> A number of series have reported on the use of minimally invasive diaphragmatic plication (MI-DP), but very little is reported on patients with diaphragmatic paralysis who do not undergo surgery. We reviewed all patients referred to us for consideration of MI-DP to gain insight into the epidemiology and natural history of the disease, and how this may influence surgical decision-making. <h3>Methods</h3> We retrospectively reviewed all patients referred for consideration of MIS-DP from April 2017 to May 2022 to analyse demographic, clinical and radiographic data. In all cases, before surgery was performed, there was a minimum 18-month observation policy from first documented evidence of paralysis. <h3>Results</h3> 58 patients were referred and screened. Demographics, aetiology, symptoms, physiological and radiological aspects are summarised in table 1. Radiological and/or symptomatic evidence of diaphragmatic paralysis was present for a median of 20 months (3–134) from onset to first surgical assessment. 15 patients (26%) underwent MIS-DP (M:F 8:7, median age 56, 22–77); symptomatic improvement was achieved in 14 (98%). 15 patients (26%) remained under review. 28 patients (48%) were rejected for surgery (reasons also reported in table 1). Of these, 8 were rejected due to symptomatic improvement, while 5 showed spontaneous recovery at a later stage after being turned down. In this subgroup (n=13, 22%), median time from onset to recovery was 32 months (21–68). Patients were more predominantly male (84%), younger (median 52), had slightly higher FEV1 (median 74%) and FVC (median 78%). Despite VC drop >15% being more frequent (46%), presence of paradoxical movement was less likely (23% only). The proportion of patients with severe symptoms was however similar, as it was radiological severity on CXR, laterality and distribution of aetiology. <h3>Conclusion</h3> Diaphragmatic paralysis is a complex condition for which spontaneous recovery is not uncommon and surgery is indicated in select cases. A multidimensional assessment is required as no single aspect alone seems able to predict evolution. Our results support the continuation of a judicious 18-month minimum observation policy, which could merit extension for certain patients." @default.
- W4311698899 created "2022-12-28" @default.
- W4311698899 creator A5053827480 @default.
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- W4311698899 date "2022-11-01" @default.
- W4311698899 modified "2023-10-17" @default.
- W4311698899 title "P110 The untold tale of diaphragmatic paralysis: epidemiology, natural history and decision-making for surgical repair" @default.
- W4311698899 doi "https://doi.org/10.1136/thorax-2022-btsabstracts.246" @default.
- W4311698899 hasPublicationYear "2022" @default.
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