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- W4311700521 abstract "During chronic antigen exposure, a subset of exhausted CD8+ T cells differentiate into stem cell-like or progenitor-like T cells expressing both transcription factor Tcf-1 (T cell factor-1) and co-inhibitory receptor PD-1. These Tcf-1+ stem-like or progenitor exhausted T cells represent the key target for immunotherapies. Deeper understanding of the biology of Tcf-1+PD-1+ CD8+ T cells will lead to rational design of future immunotherapies. Here, we summarize recent findings about the migratory and resident behavior of Tcf-1+ T cells. Specifically, we will focus on TGF-β-dependent lymphoid tissue residency program of Tcf-1+ T cells, which may represent a key to understanding the differentiation and maintenance of Tcf-1+ stem-like CD8+ T cells during persistent antigen stimulation." @default.
- W4311700521 created "2022-12-28" @default.
- W4311700521 creator A5014439688 @default.
- W4311700521 creator A5018268124 @default.
- W4311700521 date "2022-12-07" @default.
- W4311700521 modified "2023-09-25" @default.
- W4311700521 title "Lymphoid tissue residency: A key to understand Tcf-1+PD-1+ T cells" @default.
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- W4311700521 doi "https://doi.org/10.3389/fimmu.2022.1074698" @default.
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