FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311700592> ?p ?o ?g. }

• W4311700592 abstract "ABSTRACT Cellular plasminogen (Pg) receptors (PgR) are utilized to recruit Pg, stimulate its activation to the serine protease, plasmin (Pm), and sterically protect the generated Pm from inactivation by natural host inhibitors. The net result is that cells contain a stable proteolytic surface used for biological mechanisms involved in cell migration. One such PgR is the moonlighting enzyme, enolase, some of which leaves the cytoplasm and resides at the cell surface to potentially function as a PgR. Since microbes employ conscription of host Pg by PgRs as one virulence mechanism, we explored the structural basis of the ability of Streptococcus pyogenes enolase (Sen) to function in this regard. Employing single-particle cryo-electron microscopy (cryo-EM), recombinant Sen from S. pyogenes was modeled at 2.6 Å as a stable symmetrical homooctamer displaying point group 422 (D4) symmetry, with a monomeric subunit molecular weight of ~49 kDa. Subunit-subunit interactions showed four major and four minor interfaces in the octamer. Binding sites for hPg were previously proposed to include the COOH-terminal K 434,435 residues of Sen, but in native Sen these residues are buried within the minor interfaces of the octamer and do not function as a Pg binding epitope. Whereas Sen and hPg do not interact in solution, when Sen is bound to a surface, hPg interacts with Sen independently of K 434,434 . We propose that the octameric structure of Sen is important to its ability to interact with hPg, but disruption of its overall octameric conformation without dissociation of the octamer exposes neoepitopes for hPg binding." @default.
• W4311700592 created "2022-12-28" @default.
• W4311700592 creator A5036470972 @default.
• W4311700592 creator A5050593261 @default.
• W4311700592 creator A5082840407 @default.
• W4311700592 creator A5084762380 @default.
• W4311700592 date "2022-12-06" @default.
• W4311700592 modified "2023-09-24" @default.
• W4311700592 title "A high-resolution single-particle cryo-EM hydrated structure of<i>Streptococcus pyogenes</i>enolase offers insights into its function as a plasminogen receptor" @default.
• W4311700592 cites W108760005 @default.
• W4311700592 cites W1575825966 @default.
• W4311700592 cites W1608138774 @default.
• W4311700592 cites W1622871881 @default.
• W4311700592 cites W1838014421 @default.
• W4311700592 cites W1878063116 @default.
• W4311700592 cites W1978665246 @default.
• W4311700592 cites W1990882513 @default.
• W4311700592 cites W2023989921 @default.
• W4311700592 cites W2033647971 @default.
• W4311700592 cites W2035376062 @default.
• W4311700592 cites W2038073946 @default.
• W4311700592 cites W2039797673 @default.
• W4311700592 cites W2042314261 @default.
• W4311700592 cites W2045122069 @default.
• W4311700592 cites W2046493944 @default.
• W4311700592 cites W2049593412 @default.
• W4311700592 cites W2059312712 @default.
• W4311700592 cites W2062831002 @default.
• W4311700592 cites W2065172521 @default.
• W4311700592 cites W2066578236 @default.
• W4311700592 cites W2068047966 @default.
• W4311700592 cites W2070214660 @default.
• W4311700592 cites W2079830634 @default.
• W4311700592 cites W2081250069 @default.
• W4311700592 cites W2095036479 @default.
• W4311700592 cites W2095847870 @default.
• W4311700592 cites W2103647828 @default.
• W4311700592 cites W2127694483 @default.
• W4311700592 cites W2134592108 @default.
• W4311700592 cites W2147203214 @default.
• W4311700592 cites W2150922454 @default.
• W4311700592 cites W2155476753 @default.
• W4311700592 cites W2156861139 @default.
• W4311700592 cites W2157900089 @default.
• W4311700592 cites W2159762359 @default.
• W4311700592 cites W2301668719 @default.
• W4311700592 cites W2312350416 @default.
• W4311700592 cites W2337035537 @default.
• W4311700592 cites W2513507568 @default.
• W4311700592 cites W2587625522 @default.
• W4311700592 cites W2591899840 @default.
• W4311700592 cites W2593511418 @default.
• W4311700592 cites W2791030740 @default.
• W4311700592 cites W2922359080 @default.
• W4311700592 cites W2935946695 @default.
• W4311700592 cites W2946553245 @default.
• W4311700592 cites W2953320394 @default.
• W4311700592 cites W2981719851 @default.
• W4311700592 cites W2990838964 @default.
• W4311700592 cites W3127652098 @default.
• W4311700592 cites W3154855081 @default.
• W4311700592 cites W51183767 @default.
• W4311700592 doi "https://doi.org/10.1101/2022.12.06.518574" @default.
• W4311700592 hasPublicationYear "2022" @default.
• W4311700592 type Work @default.
• W4311700592 citedByCount "0" @default.
• W4311700592 crossrefType "posted-content" @default.
• W4311700592 hasAuthorship W4311700592A5036470972 @default.
• W4311700592 hasAuthorship W4311700592A5050593261 @default.
• W4311700592 hasAuthorship W4311700592A5082840407 @default.
• W4311700592 hasAuthorship W4311700592A5084762380 @default.
• W4311700592 hasBestOaLocation W43117005921 @default.
• W4311700592 hasConcept C104292427 @default.
• W4311700592 hasConcept C104317684 @default.
• W4311700592 hasConcept C12554922 @default.
• W4311700592 hasConcept C151730666 @default.
• W4311700592 hasConcept C166342909 @default.
• W4311700592 hasConcept C170493617 @default.
• W4311700592 hasConcept C173681060 @default.
• W4311700592 hasConcept C175156509 @default.
• W4311700592 hasConcept C185592680 @default.
• W4311700592 hasConcept C188618488 @default.
• W4311700592 hasConcept C203014093 @default.
• W4311700592 hasConcept C204232928 @default.
• W4311700592 hasConcept C2777339483 @default.
• W4311700592 hasConcept C2779306812 @default.
• W4311700592 hasConcept C2779489039 @default.
• W4311700592 hasConcept C43369102 @default.
• W4311700592 hasConcept C47701112 @default.
• W4311700592 hasConcept C523546767 @default.
• W4311700592 hasConcept C54355233 @default.
• W4311700592 hasConcept C55493867 @default.
• W4311700592 hasConcept C64927066 @default.
• W4311700592 hasConcept C84772758 @default.
• W4311700592 hasConcept C86803240 @default.
• W4311700592 hasConceptScore W4311700592C104292427 @default.
• W4311700592 hasConceptScore W4311700592C104317684 @default.
• W4311700592 hasConceptScore W4311700592C12554922 @default.
• W4311700592 hasConceptScore W4311700592C151730666 @default.
• W4311700592 hasConceptScore W4311700592C166342909 @default.

• next