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• W4311700922 abstract "Summary Complex cellular interactions between the immune system and cancer can impact tumour development, growth, and progression. T cells play a key role in these interactions; however, the challenge for T cells is to recognize tumour antigens whilst minimizing cross-reactivity with antigens associated with healthy tissue. Some tumour cells, including those associated with viral infections, have clear, tumour-specific antigens that can be targeted by T cells. A high mutational burden can lead to increased numbers of mutational neoantigens that allow very specific immune responses to be generated but also allow escape variants to develop. Other cancer indications and those with low mutational burden are less easily distinguished from normal tissue. Recent studies have suggested that cancer-associated alterations in tumour cell biology including changes in post-translational modification (PTM) patterns may also lead to novel antigens that can be directly recognized by T cells. The PTM-derived antigens provide tumour-specific T-cell responses that both escape central tolerance and avoid the necessity for individualized therapies. PTM-specific CD4 T-cell responses have shown tumour therapy in murine models and highlight the importance of CD4 T cells as well as CD8 T cells in reversing the immunosuppressive tumour microenvironment. Understanding which cancer-specific antigens can be recognized by T cells and the way that immune tolerance and the tumour microenvironment shape immune responses to cancer is vital for the future development of cancer therapies." @default.
• W4311700922 created "2022-12-28" @default.
• W4311700922 creator A5007328073 @default.
• W4311700922 creator A5029353304 @default.
• W4311700922 creator A5033099606 @default.
• W4311700922 creator A5035005938 @default.
• W4311700922 creator A5064156337 @default.
• W4311700922 creator A5089356328 @default.
• W4311700922 date "2022-12-06" @default.
• W4311700922 modified "2023-10-14" @default.
• W4311700922 title "What do cancer-specific T cells ‘see’?" @default.
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