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- W4311703114 abstract "Abstract Non-epileptic seizures are identified as a common epileptogenic trigger. Early metaplasticity following seizures may contribute to epileptogenesis by abnormally altering synaptic strength and homeostatic plasticity. We now studied how in vitro epileptiform activity triggers early changes in CA1 long-term potentiation (LTP) induced by theta-burst stimulation (TBS) in rat hippocampal slices and the involvement of lipid rafts in these early metaplasticity events. Two forms of epileptiform activity (EA) were induced: 1) interictal-like EA triggered by withdrawal of Mg 2+ and K + elevation to 6mM in the superfusion medium or 2) ictal-like EA induced by bicuculine (10μM) delivery. LTP induced 30 min post EA was impaired, an effect more pronounced after ictal-like EA. LTP recovered to control levels 60 min post interictal-like EA but was still impaired 60 min after ictal-like EA. The synaptic molecular events underlying this altered LTP were investigated 30 min post EA. Synaptosomes isolated from parallel slices showed enhanced AMPA GluA1 Ser831 phosphorylation but decreased Ser 845 phosphorylation and a marked decrease in GluA1/GluA2 ratio. A marked decrease in flotillin-1 and caveolin-1 levels concomitantly with a moderate increase in PSD-95 and marked increase in gephyrin levels. Altogether, EA differentially influences hippocampal CA1 LTP thorough regulation of GluA1/GluA2 levels and AMPA GluA1 phosphorylation suggesting altered LTP post-seizures may be a relevant target of antiepileptogenic therapies. In addition, this metaplasticity is also associated with marked alterations in classic and synaptic lipid raft markers, suggesting these may also constitute promising targets in epileptogenesis prevention." @default.
- W4311703114 created "2022-12-28" @default.
- W4311703114 creator A5027568151 @default.
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- W4311703114 creator A5053744677 @default.
- W4311703114 creator A5055295321 @default.
- W4311703114 creator A5057426890 @default.
- W4311703114 date "2022-12-06" @default.
- W4311703114 modified "2023-09-27" @default.
- W4311703114 title "Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for lipid raft dynamics in early metaplasticity" @default.
- W4311703114 cites W108664672 @default.
- W4311703114 cites W1550524407 @default.
- W4311703114 cites W1557771190 @default.
- W4311703114 cites W1617948373 @default.
- W4311703114 cites W1972482555 @default.
- W4311703114 cites W1973533307 @default.
- W4311703114 cites W1974367131 @default.
- W4311703114 cites W1974528572 @default.
- W4311703114 cites W1976598676 @default.
- W4311703114 cites W1977253719 @default.
- W4311703114 cites W1983252720 @default.
- W4311703114 cites W1983456012 @default.
- W4311703114 cites W1985966523 @default.
- W4311703114 cites W1992226873 @default.
- W4311703114 cites W1993241283 @default.
- W4311703114 cites W1993443442 @default.
- W4311703114 cites W1994794429 @default.
- W4311703114 cites W1999906572 @default.
- W4311703114 cites W2000629783 @default.
- W4311703114 cites W2008774676 @default.
- W4311703114 cites W2011469680 @default.
- W4311703114 cites W2012872872 @default.
- W4311703114 cites W2014270209 @default.
- W4311703114 cites W2014995849 @default.
- W4311703114 cites W2015430216 @default.
- W4311703114 cites W2017618304 @default.
- W4311703114 cites W2018930679 @default.
- W4311703114 cites W2024831991 @default.
- W4311703114 cites W2037015340 @default.
- W4311703114 cites W2038280427 @default.
- W4311703114 cites W2038519029 @default.
- W4311703114 cites W2040347331 @default.
- W4311703114 cites W2043634258 @default.
- W4311703114 cites W2053187308 @default.
- W4311703114 cites W2054628503 @default.
- W4311703114 cites W2058572310 @default.
- W4311703114 cites W2058930537 @default.
- W4311703114 cites W2066358338 @default.
- W4311703114 cites W2067066246 @default.
- W4311703114 cites W2068958444 @default.
- W4311703114 cites W2081988754 @default.
- W4311703114 cites W2089413793 @default.
- W4311703114 cites W2092155648 @default.
- W4311703114 cites W2106492868 @default.
- W4311703114 cites W2128862836 @default.
- W4311703114 cites W2142181855 @default.
- W4311703114 cites W2152044871 @default.
- W4311703114 cites W2153162096 @default.
- W4311703114 cites W2153892947 @default.
- W4311703114 cites W2157228939 @default.
- W4311703114 cites W2165570345 @default.
- W4311703114 cites W2166494613 @default.
- W4311703114 cites W2168319429 @default.
- W4311703114 cites W2319723740 @default.
- W4311703114 cites W2481671282 @default.
- W4311703114 cites W2507555648 @default.
- W4311703114 cites W2514378822 @default.
- W4311703114 cites W2521658051 @default.
- W4311703114 cites W2560629319 @default.
- W4311703114 cites W2593617453 @default.
- W4311703114 cites W2743912370 @default.
- W4311703114 cites W2751162263 @default.
- W4311703114 cites W2767248639 @default.
- W4311703114 cites W2768199509 @default.
- W4311703114 cites W2786519072 @default.
- W4311703114 cites W2883615957 @default.
- W4311703114 cites W2895257150 @default.
- W4311703114 cites W2897057615 @default.
- W4311703114 cites W2898610081 @default.
- W4311703114 cites W2912679084 @default.
- W4311703114 cites W2917576966 @default.
- W4311703114 cites W2945567856 @default.
- W4311703114 cites W2946318369 @default.
- W4311703114 cites W2954314772 @default.
- W4311703114 cites W2966533410 @default.
- W4311703114 cites W2969420263 @default.
- W4311703114 cites W2995822259 @default.
- W4311703114 cites W3047413884 @default.
- W4311703114 cites W3047891029 @default.
- W4311703114 cites W3050120412 @default.
- W4311703114 cites W3095738444 @default.
- W4311703114 cites W3097654994 @default.
- W4311703114 cites W3111419394 @default.
- W4311703114 cites W3120392574 @default.
- W4311703114 cites W3137199685 @default.
- W4311703114 cites W3153119306 @default.
- W4311703114 cites W3179121572 @default.
- W4311703114 cites W3182251250 @default.
- W4311703114 cites W3202710969 @default.
- W4311703114 cites W4210974819 @default.