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- W4311704134 abstract "In recent studies published in Science and Nature Communications, three independent groups identified TMEM251, one transmembrane protein in Golgi, is an indispensable factor for lysosomal enzyme trafficking. Loss or mutation of TMEM251 results in hypersecretion of lysosomal enzymes due to lack of mannose-6-phosphate (M6P) modification, leading to lysosomal dysfunction and eventually lysosome storage disorders (LSDs)." @default.
- W4311704134 created "2022-12-28" @default.
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- W4311704134 date "2022-12-17" @default.
- W4311704134 modified "2023-10-05" @default.
- W4311704134 title "TMEM251, a new player in lysosomal enzyme trafficking" @default.
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- W4311704134 doi "https://doi.org/10.1093/lifemeta/loac039" @default.
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