Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311704346> ?p ?o ?g. }
- W4311704346 endingPage "173" @default.
- W4311704346 startingPage "163" @default.
- W4311704346 abstract "Introduction Chronic obstructive pulmonary disease (COPD) is a disorder characterized by a complicated chronic inflammatory response that is resistant to corticosteroid therapy. As a result, there is a critical need for effective anti-inflammatory medications to treat people with COPD. Using monoclonal antibodies (mAbs) to inhibit cytokines and chemokines or their receptors could be a potential approach to treating the inflammatory component of COPD.Areas covered The therapeutic potential that some of these mAbs might have in COPD is reviewed.Expert opinion No mAb directed against cytokines or chemokines has shown any therapeutic impact in COPD patients, apart from mAbs targeting the IL-5 pathway that appear to have statistically significant, albeit weak, effect in patients with eosinophilic COPD. This may reflect the complexity of COPD, in which no single cytokine or chemokine has a dominant role. Because the umbrella term COPD encompasses several endotypes with diverse underlying processes, mAbs targeting specific cytokines or chemokines should most likely be evaluated in limited and focused populations." @default.
- W4311704346 created "2022-12-28" @default.
- W4311704346 creator A5050589916 @default.
- W4311704346 creator A5053217610 @default.
- W4311704346 creator A5060089859 @default.
- W4311704346 creator A5062907116 @default.
- W4311704346 creator A5072493273 @default.
- W4311704346 date "2022-12-26" @default.
- W4311704346 modified "2023-10-03" @default.
- W4311704346 title "Biologic therapies for chronic obstructive pulmonary disease" @default.
- W4311704346 cites W146790210 @default.
- W4311704346 cites W1757801909 @default.
- W4311704346 cites W1787903757 @default.
- W4311704346 cites W1854658697 @default.
- W4311704346 cites W1935159738 @default.
- W4311704346 cites W1970028992 @default.
- W4311704346 cites W1994779731 @default.
- W4311704346 cites W1996136023 @default.
- W4311704346 cites W2001220620 @default.
- W4311704346 cites W2019394772 @default.
- W4311704346 cites W2022188895 @default.
- W4311704346 cites W2030108904 @default.
- W4311704346 cites W2033683444 @default.
- W4311704346 cites W2034058980 @default.
- W4311704346 cites W2034711268 @default.
- W4311704346 cites W2039270725 @default.
- W4311704346 cites W2058065781 @default.
- W4311704346 cites W2075964458 @default.
- W4311704346 cites W2077917566 @default.
- W4311704346 cites W2080299160 @default.
- W4311704346 cites W2096567616 @default.
- W4311704346 cites W2096651238 @default.
- W4311704346 cites W2107610047 @default.
- W4311704346 cites W2128190180 @default.
- W4311704346 cites W2133119717 @default.
- W4311704346 cites W2136822492 @default.
- W4311704346 cites W2142195757 @default.
- W4311704346 cites W2145370817 @default.
- W4311704346 cites W2166049797 @default.
- W4311704346 cites W2171875475 @default.
- W4311704346 cites W2176721723 @default.
- W4311704346 cites W2179074340 @default.
- W4311704346 cites W2398413522 @default.
- W4311704346 cites W2467573936 @default.
- W4311704346 cites W2508357902 @default.
- W4311704346 cites W2511267861 @default.
- W4311704346 cites W2562179046 @default.
- W4311704346 cites W2593002735 @default.
- W4311704346 cites W2595314229 @default.
- W4311704346 cites W2608737345 @default.
- W4311704346 cites W2620841583 @default.
- W4311704346 cites W2739692869 @default.
- W4311704346 cites W2761511671 @default.
- W4311704346 cites W2776823702 @default.
- W4311704346 cites W2788654997 @default.
- W4311704346 cites W2795098310 @default.
- W4311704346 cites W2795748093 @default.
- W4311704346 cites W2800326251 @default.
- W4311704346 cites W2903929541 @default.
- W4311704346 cites W2912998273 @default.
- W4311704346 cites W2921533322 @default.
- W4311704346 cites W2935954941 @default.
- W4311704346 cites W2944047291 @default.
- W4311704346 cites W2944802131 @default.
- W4311704346 cites W2965980836 @default.
- W4311704346 cites W2968943016 @default.
- W4311704346 cites W2971346861 @default.
- W4311704346 cites W2975842537 @default.
- W4311704346 cites W2985732505 @default.
- W4311704346 cites W2990642475 @default.
- W4311704346 cites W2991213077 @default.
- W4311704346 cites W2995019413 @default.
- W4311704346 cites W3007780891 @default.
- W4311704346 cites W3040807924 @default.
- W4311704346 cites W3044708056 @default.
- W4311704346 cites W3080244005 @default.
- W4311704346 cites W3081661050 @default.
- W4311704346 cites W3095117711 @default.
- W4311704346 cites W3108245859 @default.
- W4311704346 cites W3111995339 @default.
- W4311704346 cites W3118746794 @default.
- W4311704346 cites W3120027527 @default.
- W4311704346 cites W3121747711 @default.
- W4311704346 cites W3134224893 @default.
- W4311704346 cites W3142636974 @default.
- W4311704346 cites W3159126992 @default.
- W4311704346 cites W3159888010 @default.
- W4311704346 cites W3167507754 @default.
- W4311704346 cites W3185379947 @default.
- W4311704346 cites W3194169823 @default.
- W4311704346 cites W3208979749 @default.
- W4311704346 cites W4205283895 @default.
- W4311704346 cites W4205639217 @default.
- W4311704346 cites W4221037414 @default.
- W4311704346 cites W4225306386 @default.
- W4311704346 cites W4225327007 @default.
- W4311704346 cites W4283363538 @default.
- W4311704346 cites W4289782677 @default.