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- W4311706608 abstract "Xenotransplantation has the potential to solve the shortfall of human organ donors. Genetically modified pigs have been considered as potential animal donors for human xenotransplantation and have been widely used in preclinical research. The genetic modifications aim to prevent the major species-specific barriers, which include humoral and cellular immune responses, and physiological incompatibilities such as complement and coagulation dysfunctions. Genetically modified pigs can be created by deleting several pig genes related to the synthesis of various pig specific antigens or by inserting human complement- and coagulation-regulatory transgenes. Finally, in order to reduce the risk of infection, genes related to porcine endogenous retroviruses can be knocked down. In this review, we focus on genetically modified pigs and comprehensively summarize the immunological mechanism of xenograft rejection and recent progress in preclinical and clinical studies. Overall, both genetically engineered pig-based xenografts and technological breakthroughs in the biomedical field provide a promising foundation for pig-to-human xenotransplantation in the future." @default.
- W4311706608 created "2022-12-28" @default.
- W4311706608 creator A5005669008 @default.
- W4311706608 creator A5009527431 @default.
- W4311706608 creator A5029667848 @default.
- W4311706608 creator A5046399093 @default.
- W4311706608 creator A5068581881 @default.
- W4311706608 creator A5071432504 @default.
- W4311706608 creator A5078143614 @default.
- W4311706608 date "2022-12-06" @default.
- W4311706608 modified "2023-10-14" @default.
- W4311706608 title "Genetic engineering of pigs for xenotransplantation to overcome immune rejection and physiological incompatibilities: The first clinical steps" @default.
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