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- W4311719608 endingPage "1768" @default.
- W4311719608 startingPage "1768" @default.
- W4311719608 abstract "Despite progress in biomedical technologies, cardiovascular disease remains the main cause of mortality. This is at least in part because current clinical interventions do not adequately take into account aging as a driver and are hence aimed at suboptimal targets. To achieve progress, consideration needs to be given to the role of cell aging in disease pathogenesis. We propose a model unifying the fundamental processes underlying most age-associated cardiovascular pathologies. According to this model, cell aging, leading to cell senescence, is responsible for tissue changes leading to age-related cardiovascular disease. This process, occurring due to telomerase inactivation and telomere attrition, affects all components of the cardiovascular system, including cardiomyocytes, vascular endothelial cells, smooth muscle cells, cardiac fibroblasts, and immune cells. The unified model offers insights into the relationship between upstream risk factors and downstream clinical outcomes and explains why interventions aimed at either of these components have limited success. Potential therapeutic approaches are considered based on this model. Because telomerase activity can prevent and reverse cell senescence, telomerase gene therapy is discussed as a promising intervention. Telomerase gene therapy and similar systems interventions based on the unified model are expected to be transformational in cardiovascular medicine." @default.
- W4311719608 created "2022-12-28" @default.
- W4311719608 creator A5015736762 @default.
- W4311719608 creator A5021912710 @default.
- W4311719608 creator A5028819467 @default.
- W4311719608 creator A5086201600 @default.
- W4311719608 date "2022-12-06" @default.
- W4311719608 modified "2023-09-30" @default.
- W4311719608 title "A Unified Model of Age-Related Cardiovascular Disease" @default.
- W4311719608 cites W164657808 @default.
- W4311719608 cites W1866068290 @default.
- W4311719608 cites W1908141864 @default.
- W4311719608 cites W1934246519 @default.
- W4311719608 cites W1952870193 @default.
- W4311719608 cites W1976416423 @default.
- W4311719608 cites W1979030852 @default.
- W4311719608 cites W1979176867 @default.
- W4311719608 cites W1985399572 @default.
- W4311719608 cites W1985461968 @default.
- W4311719608 cites W1989020172 @default.
- W4311719608 cites W1990423201 @default.
- W4311719608 cites W1990704631 @default.
- W4311719608 cites W1991243079 @default.
- W4311719608 cites W1991425040 @default.
- W4311719608 cites W1991590201 @default.
- W4311719608 cites W1993500521 @default.
- W4311719608 cites W1993856759 @default.
- W4311719608 cites W1994046047 @default.
- W4311719608 cites W1994328569 @default.
- W4311719608 cites W1996920927 @default.
- W4311719608 cites W1997335329 @default.
- W4311719608 cites W2001258453 @default.
- W4311719608 cites W2002437748 @default.
- W4311719608 cites W2004314923 @default.
- W4311719608 cites W2025966812 @default.
- W4311719608 cites W2030120780 @default.
- W4311719608 cites W2031568274 @default.
- W4311719608 cites W2031792875 @default.
- W4311719608 cites W2034297028 @default.
- W4311719608 cites W2037192636 @default.
- W4311719608 cites W2044642112 @default.
- W4311719608 cites W2049170821 @default.
- W4311719608 cites W2049680139 @default.
- W4311719608 cites W2050802679 @default.
- W4311719608 cites W2052278932 @default.
- W4311719608 cites W2053352181 @default.
- W4311719608 cites W2059660749 @default.
- W4311719608 cites W2060347940 @default.
- W4311719608 cites W2063324473 @default.
- W4311719608 cites W2066752981 @default.
- W4311719608 cites W2067349642 @default.
- W4311719608 cites W2069119991 @default.
- W4311719608 cites W2069519394 @default.
- W4311719608 cites W2074885541 @default.
- W4311719608 cites W2078937537 @default.
- W4311719608 cites W2082399402 @default.
- W4311719608 cites W2082822668 @default.
- W4311719608 cites W2083439327 @default.
- W4311719608 cites W2087402926 @default.
- W4311719608 cites W2091735481 @default.
- W4311719608 cites W2093382132 @default.
- W4311719608 cites W2096531787 @default.
- W4311719608 cites W2096761587 @default.
- W4311719608 cites W2096880686 @default.
- W4311719608 cites W2102172732 @default.
- W4311719608 cites W2102910849 @default.
- W4311719608 cites W2103428818 @default.
- W4311719608 cites W2105307472 @default.
- W4311719608 cites W2108106334 @default.
- W4311719608 cites W2108482850 @default.
- W4311719608 cites W2109196816 @default.
- W4311719608 cites W2112049232 @default.
- W4311719608 cites W2113072982 @default.
- W4311719608 cites W2113741117 @default.
- W4311719608 cites W2114777743 @default.
- W4311719608 cites W2115415613 @default.
- W4311719608 cites W2120923197 @default.
- W4311719608 cites W2131855555 @default.
- W4311719608 cites W2134676982 @default.
- W4311719608 cites W2138661165 @default.
- W4311719608 cites W2138670750 @default.
- W4311719608 cites W2138834299 @default.
- W4311719608 cites W2142403329 @default.
- W4311719608 cites W2145331177 @default.
- W4311719608 cites W2145805076 @default.
- W4311719608 cites W2148768345 @default.
- W4311719608 cites W2151009383 @default.
- W4311719608 cites W2153623205 @default.
- W4311719608 cites W2154676325 @default.
- W4311719608 cites W2155121555 @default.
- W4311719608 cites W2155554546 @default.
- W4311719608 cites W2156848121 @default.
- W4311719608 cites W2159652870 @default.
- W4311719608 cites W2165096496 @default.
- W4311719608 cites W2166910397 @default.
- W4311719608 cites W2167634473 @default.
- W4311719608 cites W2168198236 @default.
- W4311719608 cites W2168718017 @default.