Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311724830> ?p ?o ?g. }
- W4311724830 endingPage "3143" @default.
- W4311724830 startingPage "3143" @default.
- W4311724830 abstract "There is significant interest in the role of stem cells in cardiac regeneration, and yet little is known about how cardiac disease progression affects native cardiac stem cells in the human heart. In this brief report, cardiac mesenchymal stem cell-like cells (CMSCLC) from the right atria of a 21-year-old female patient with a bicuspid aortic valve and aortic stenosis (referred to as biscuspid aortic valve disease BAVD-CMSCLC), were compared with those of a 78-year-old female patient undergoing coronary artery bypass surgery (referred to as coronary artery disease CAD-CMSCLC). Cells were analyzed for expression of MSC markers, ability to form CFU-Fs, metabolic activity, cell cycle kinetics, expression of NANOG and p16, and telomere length. The cardiac-derived cells expressed MSC markers and were able to form CFU-Fs, with higher rate of formation in CAD-CMSCLCs. BAVD-CMSCLCs did not display normal MSC morphology, had a much lower cell doubling rate, and were less metabolically active than CAD-CMSCLCs. Cell cycle analysis revealed a population of BAVD-CMSCLC in G2/M phase, whereas the bulk of CAD-CMSCLC were in the G0/G1 phase. BAVD-CMSCLC had lower expression of NANOG and shorter telomere lengths, but higher expression of p16 compared with the CAD-CMSCLC. In conclusion, BAVD-CMSCLC have a prematurely aged phenotype compared with CAD-CMSCLC, despite originating from a younger patient." @default.
- W4311724830 created "2022-12-28" @default.
- W4311724830 creator A5006198474 @default.
- W4311724830 creator A5009128727 @default.
- W4311724830 creator A5038933168 @default.
- W4311724830 creator A5062701067 @default.
- W4311724830 creator A5064491988 @default.
- W4311724830 creator A5068897692 @default.
- W4311724830 date "2022-12-06" @default.
- W4311724830 modified "2023-10-15" @default.
- W4311724830 title "Cardiac Mesenchymal Stem Cell-like Cells Derived from a Young Patient with Bicuspid Aortic Valve Disease Have a Prematurely Aged Phenotype" @default.
- W4311724830 cites W1978511802 @default.
- W4311724830 cites W1985311481 @default.
- W4311724830 cites W1993977909 @default.
- W4311724830 cites W2003619963 @default.
- W4311724830 cites W2004247546 @default.
- W4311724830 cites W2004602806 @default.
- W4311724830 cites W2015548719 @default.
- W4311724830 cites W2025371271 @default.
- W4311724830 cites W2028339142 @default.
- W4311724830 cites W2030833321 @default.
- W4311724830 cites W2058446860 @default.
- W4311724830 cites W2060134459 @default.
- W4311724830 cites W2080539468 @default.
- W4311724830 cites W2086588348 @default.
- W4311724830 cites W2097766446 @default.
- W4311724830 cites W2100313400 @default.
- W4311724830 cites W2111486034 @default.
- W4311724830 cites W2115852450 @default.
- W4311724830 cites W2116254970 @default.
- W4311724830 cites W2121774318 @default.
- W4311724830 cites W2121967184 @default.
- W4311724830 cites W2129839972 @default.
- W4311724830 cites W2141755216 @default.
- W4311724830 cites W2163229747 @default.
- W4311724830 cites W2172126964 @default.
- W4311724830 cites W2266290735 @default.
- W4311724830 cites W2555325526 @default.
- W4311724830 cites W2568319444 @default.
- W4311724830 cites W2576152462 @default.
- W4311724830 cites W2611412318 @default.
- W4311724830 cites W2765979567 @default.
- W4311724830 cites W2775582148 @default.
- W4311724830 cites W2776089834 @default.
- W4311724830 cites W2790547652 @default.
- W4311724830 cites W2805637759 @default.
- W4311724830 cites W2814892626 @default.
- W4311724830 cites W2888679536 @default.
- W4311724830 cites W2890362621 @default.
- W4311724830 cites W2911496216 @default.
- W4311724830 cites W2912654909 @default.
- W4311724830 cites W2913284769 @default.
- W4311724830 cites W2916821145 @default.
- W4311724830 cites W2917025828 @default.
- W4311724830 cites W2922300104 @default.
- W4311724830 cites W2931875016 @default.
- W4311724830 cites W2944583173 @default.
- W4311724830 cites W2944902958 @default.
- W4311724830 cites W2949100461 @default.
- W4311724830 cites W2954376097 @default.
- W4311724830 cites W2965272246 @default.
- W4311724830 cites W3022659605 @default.
- W4311724830 cites W3032316377 @default.
- W4311724830 cites W3037517882 @default.
- W4311724830 cites W3089255423 @default.
- W4311724830 cites W3089915860 @default.
- W4311724830 cites W3092193422 @default.
- W4311724830 cites W3111207111 @default.
- W4311724830 cites W3111851840 @default.
- W4311724830 cites W3130773856 @default.
- W4311724830 cites W3147103840 @default.
- W4311724830 cites W3178452188 @default.
- W4311724830 cites W3201314047 @default.
- W4311724830 cites W4212916290 @default.
- W4311724830 cites W4292163501 @default.
- W4311724830 cites W4296781689 @default.
- W4311724830 cites W4298087324 @default.
- W4311724830 cites W4307370114 @default.
- W4311724830 cites W4308891647 @default.
- W4311724830 cites W82391255 @default.
- W4311724830 doi "https://doi.org/10.3390/biomedicines10123143" @default.
- W4311724830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36551899" @default.
- W4311724830 hasPublicationYear "2022" @default.
- W4311724830 type Work @default.
- W4311724830 citedByCount "0" @default.
- W4311724830 crossrefType "journal-article" @default.
- W4311724830 hasAuthorship W4311724830A5006198474 @default.
- W4311724830 hasAuthorship W4311724830A5009128727 @default.
- W4311724830 hasAuthorship W4311724830A5038933168 @default.
- W4311724830 hasAuthorship W4311724830A5062701067 @default.
- W4311724830 hasAuthorship W4311724830A5064491988 @default.
- W4311724830 hasAuthorship W4311724830A5068897692 @default.
- W4311724830 hasBestOaLocation W43117248301 @default.
- W4311724830 hasConcept C104317684 @default.
- W4311724830 hasConcept C107459253 @default.
- W4311724830 hasConcept C126322002 @default.
- W4311724830 hasConcept C142724271 @default.
- W4311724830 hasConcept C145103041 @default.