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• W4311724879 endingPage "15474" @default.
• W4311724879 startingPage "15474" @default.
• W4311724879 abstract "Oligonucleotides (OGNs) are relatively new modalities that offer unique opportunities to expand the therapeutic targets. Reliable and high-throughput bioanalytical methods are pivotal for preclinical and clinical investigations of therapeutic OGNs. Liquid chromatography-mass spectrometry (LC-MS) is now evolving into being the method of choice for the bioanalysis of OGNs. Ion paring reversed-phase liquid chromatography (IP-RPLC) has been widely used in sample preparation and LC-MS analysis of OGNs; however, there are technical issues associated with these methods. IP-free methods, such as hydrophilic interaction liquid chromatography (HILIC) and anion-exchange techniques, have emerged as promising approaches for the bioanalysis of OGNs. In this review, the state-of-the-art IP-RPLC-MS bioanalytical methods of OGNs and their metabolites published in the past 10 years (2012-2022) are critically reviewed. Recent advances in IP-reagent-free LC-MS bioanalysis methods are discussed. Finally, we describe future opportunities for developing new methods that can be used for the comprehensive bioanalysis of OGNs." @default.
• W4311724879 created "2022-12-28" @default.
• W4311724879 creator A5002831626 @default.
• W4311724879 creator A5028933202 @default.
• W4311724879 creator A5035358464 @default.
• W4311724879 creator A5073407872 @default.
• W4311724879 date "2022-12-07" @default.
• W4311724879 modified "2023-10-17" @default.
• W4311724879 title "Bioanalysis of Oligonucleotide by LC–MS: Effects of Ion Pairing Regents and Recent Advances in Ion-Pairing-Free Analytical Strategies" @default.
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