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• W4311731697 abstract "Abstract Background Canine heartworm is a widespread and potentially fatal mosquito-borne disease caused by infections with the parasitic nematode, Dirofilaria immitis . We have previously shown that systemic activation of the Toll immune pathway via silencing of the negative regulator Cactus in Aedes aegypti blocks parasite development in the Malpighian tubules (MT), the mosquito renal organ. However, it was not established whether the MT were directly responding to Toll activation or were alternatively responding to upregulated proteins or other changes to the hemolymph driven by other tissues. Distinguishing these possibilities is crucial for developing more precise strategies to block D. immitis while potentially avoiding the fitness cost to the mosquito associated with Cactus silencing. Methods This study defines the transcriptional response of the MT and changes to the hemolymph proteome of Ae. aegypti after systemic Toll activation via intra-thoracic injection of double-stranded Cactus (ds Cactus ) RNA. Results Malpighian tubules significantly increased expression of the Toll pathway target genes that significantly overlapped expression changes occurring in whole mosquitoes. A significant overlap between the transcriptional response of the MT and proteins upregulated in the hemolymph was also observed. Conclusions Our data show that MT are capable of RNA interference-mediated gene silencing and directly respond to ds Cactus treatment by upregulating targets of the canonical Toll pathway. Although not definitive, the strong correspondence between the MT transcriptional response and the hemolymph proteomic responses provides evidence that the MT may contribute to mosquito humoral immunity. Graphical Abstract" @default.
• W4311731697 created "2022-12-28" @default.
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• W4311731697 date "2022-12-15" @default.
• W4311731697 modified "2023-10-05" @default.
• W4311731697 title "Aedes aegypti Malpighian tubules are immunologically activated following systemic Toll activation" @default.
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• W4311731697 doi "https://doi.org/10.1186/s13071-022-05567-2" @default.
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• W4311731697 hasPublicationYear "2022" @default.
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