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- W4311731729 abstract "Secondary lymphedema is a debilitating disease characterized by abnormal soft tissue swelling and caused by lymphatic system dysfunction. Despite a high prevalence of secondary lymphedema after cancer treatments, current management is supportive and there are no approved therapeutic agents that can thwart disease progression. We have previously demonstrated that 9-cis-retinoic acid (9-cisRA) has the potential to be repurposed for lymphedema as it mitigates disease by promoting lymphangiogenesis at the site of lymphatic injury. Although the efficacy of 9-cisRA has been demonstrated in previous studies, the mechanism of action is not completely understood. In this study, we demonstrate that when RXRα is specifically deleted in lymphatic endothelial cells, 9-cisRA fails to induce lymphangiogenesis in vitro and prevent pathologic progression of postsurgical lymphedema in vivo. These findings demonstrate that downstream nuclear receptor RXRα plays a critical role in the therapeutic efficacy of 9-cisRA in postsurgical lymphedema." @default.
- W4311731729 created "2022-12-28" @default.
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- W4311731729 date "2022-12-15" @default.
- W4311731729 modified "2023-10-17" @default.
- W4311731729 title "Lymphatic endothelial cell <scp>RXRα</scp> is critical for 9‐cis‐retinoic acid‐mediated lymphangiogenesis and prevention of secondary lymphedema" @default.
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- W4311731729 doi "https://doi.org/10.1096/fj.202200146rr" @default.
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