FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311732024> ?p ?o ?g. }

• W4311732024 abstract "Abstract Background A host-protein score (BV) combining the circulating levels of TRAIL, IP-10 and CRP was developed for distinguishing bacterial from viral infection. BV’s potential to impact decision making at the emergency department (ED) was assessed by comparing BV to physician’s etiological suspicion. Methods Rosetta study participants, aged 3 months to 18 years with febrile respiratory tract infection or fever without source, were prospectively recruited in a tertiary care pediatric ED. The main eligibility criteria were symptoms for less than 7 days and immunocompetence. ED physician’s initial etiological suspicion (bacterial/viral/I don’t know) and degree of confidence (low/medium/high) were recorded in a questionnaire. BV was interpreted based on pre-defined score thresholds (viral/bacterial/equivocal); the results were not available to the physician. The etiologic reference standard was based on the diagnoses (bacterial/viral/indeterminate) of 3 independent pediatricians who were provided with all available patient data but blinded to BV. BV’s potential to impact the physician’s etiologic accuracy was estimated according to alignment between BV and etiological suspicion as filled in the questionnaire (assuming full adoption of BV by the physician). Results Among 348 patients recruited, 290 met eligibility criteria and had requisite serum sample (Figure 1A). Median age was 1.3 years (interquartile range 1.7), 37.5% were female. 211 patients had questionnaires filled. BV matched physician’s label and reference standard in 72% of the cases (151/211; Figure 1B); of these, 52% (78/151) were labeled by the physician with low/medium confidence, i.e., BV could reinforce the physician’s suspicion. In 12% of the cases (26/211) BV aligned with the reference standard but not with the physician’s suspicion, and therefore could correct the physician's etiologic diagnosis. BV did not align with the reference standard in 7% of the cases (14/211) and was equivocal in 9% of the cases (20/211). Overall, BV could potentially correct physician diagnosis and reduce error &gt;2-fold, from 16.1% to 8.1%. Figure 1.Assessing the potential impact of BV on ED physician’s etiologic accuracy. (A) Reference standard outcomes and BV scores. (B) BV versus adjudication-based reference standard and ED physician etiologic suspicion. Cases with missing questionnaire were omitted; n=211. Conclusion BV has potential to aid the diagnostic process. Future studies are warranted to assess the real-world impact of BV on ED practice. Disclosures Meital Paz, MD, MeMed: employee Oded Scheuerman, MD, MeMed: Grant/Research Support Ron Berant, MD, GE: Advisor/Consultant." @default.
• W4311732024 created "2022-12-28" @default.
• W4311732024 creator A5009086108 @default.
• W4311732024 creator A5010460036 @default.
• W4311732024 creator A5019633252 @default.
• W4311732024 creator A5020963842 @default.
• W4311732024 creator A5028802430 @default.
• W4311732024 creator A5031571700 @default.
• W4311732024 creator A5044616819 @default.
• W4311732024 creator A5052937653 @default.
• W4311732024 creator A5066170164 @default.
• W4311732024 creator A5073252756 @default.
• W4311732024 creator A5076099569 @default.
• W4311732024 creator A5082252118 @default.
• W4311732024 creator A5084887081 @default.
• W4311732024 creator A5086895031 @default.
• W4311732024 date "2022-12-01" @default.
• W4311732024 modified "2023-10-16" @default.
• W4311732024 title "528. Bacterial vs viral etiology of fever: a prospective study to estimate a host score’s potential to support ED physicians' etiologic accuracy" @default.
• W4311732024 doi "https://doi.org/10.1093/ofid/ofac492.583" @default.
• W4311732024 hasPublicationYear "2022" @default.
• W4311732024 type Work @default.
• W4311732024 citedByCount "0" @default.
• W4311732024 crossrefType "journal-article" @default.
• W4311732024 hasAuthorship W4311732024A5009086108 @default.
• W4311732024 hasAuthorship W4311732024A5010460036 @default.
• W4311732024 hasAuthorship W4311732024A5019633252 @default.
• W4311732024 hasAuthorship W4311732024A5020963842 @default.
• W4311732024 hasAuthorship W4311732024A5028802430 @default.
• W4311732024 hasAuthorship W4311732024A5031571700 @default.
• W4311732024 hasAuthorship W4311732024A5044616819 @default.
• W4311732024 hasAuthorship W4311732024A5052937653 @default.
• W4311732024 hasAuthorship W4311732024A5066170164 @default.
• W4311732024 hasAuthorship W4311732024A5073252756 @default.
• W4311732024 hasAuthorship W4311732024A5076099569 @default.
• W4311732024 hasAuthorship W4311732024A5082252118 @default.
• W4311732024 hasAuthorship W4311732024A5084887081 @default.
• W4311732024 hasAuthorship W4311732024A5086895031 @default.
• W4311732024 hasBestOaLocation W43117320241 @default.
• W4311732024 hasConcept C118552586 @default.
• W4311732024 hasConcept C119060515 @default.
• W4311732024 hasConcept C126322002 @default.
• W4311732024 hasConcept C137627325 @default.
• W4311732024 hasConcept C142724271 @default.
• W4311732024 hasConcept C187212893 @default.
• W4311732024 hasConcept C188816634 @default.
• W4311732024 hasConcept C2776012195 @default.
• W4311732024 hasConcept C2780724011 @default.
• W4311732024 hasConcept C44249647 @default.
• W4311732024 hasConcept C534262118 @default.
• W4311732024 hasConcept C534529494 @default.
• W4311732024 hasConcept C71924100 @default.
• W4311732024 hasConceptScore W4311732024C118552586 @default.
• W4311732024 hasConceptScore W4311732024C119060515 @default.
• W4311732024 hasConceptScore W4311732024C126322002 @default.
• W4311732024 hasConceptScore W4311732024C137627325 @default.
• W4311732024 hasConceptScore W4311732024C142724271 @default.
• W4311732024 hasConceptScore W4311732024C187212893 @default.
• W4311732024 hasConceptScore W4311732024C188816634 @default.
• W4311732024 hasConceptScore W4311732024C2776012195 @default.
• W4311732024 hasConceptScore W4311732024C2780724011 @default.
• W4311732024 hasConceptScore W4311732024C44249647 @default.
• W4311732024 hasConceptScore W4311732024C534262118 @default.
• W4311732024 hasConceptScore W4311732024C534529494 @default.
• W4311732024 hasConceptScore W4311732024C71924100 @default.
• W4311732024 hasIssue "Supplement_2" @default.
• W4311732024 hasLocation W43117320241 @default.
• W4311732024 hasOpenAccess W4311732024 @default.
• W4311732024 hasPrimaryLocation W43117320241 @default.
• W4311732024 hasRelatedWork W1972441799 @default.
• W4311732024 hasRelatedWork W2067016513 @default.
• W4311732024 hasRelatedWork W2077799171 @default.
• W4311732024 hasRelatedWork W2096401844 @default.
• W4311732024 hasRelatedWork W2121088139 @default.
• W4311732024 hasRelatedWork W2796975958 @default.
• W4311732024 hasRelatedWork W2894880064 @default.
• W4311732024 hasRelatedWork W3087018904 @default.
• W4311732024 hasRelatedWork W4210965847 @default.
• W4311732024 hasRelatedWork W4317359064 @default.
• W4311732024 hasVolume "9" @default.
• W4311732024 isParatext "false" @default.
• W4311732024 isRetracted "false" @default.
• W4311732024 workType "article" @default.