Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311732330> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4311732330 abstract "Abstract Background Increasing rates of antibiotic resistance has emerged as one of the top concerns in health care. New resistance mechanisms such as carbapenemase production present a challenge in treating common infections. Novel antibiotics are being developed to tackle these pathogens, and one of the newest drugs in this arsenal is cefiderocol, a siderophore cephalosporin. Real-world data regarding the clinical use and outcomes of cefiderocol is limited. Methods A single-center, retrospective chart review was completed from July 2020 to March 2022 and included adult patients who received at least one dose of cefiderocol. Patient baseline characteristics were obtained along with other variables related to the primary infection. The primary outcome was clinical failure defined as 30 day mortality following cefiderocol administration. Secondary outcomes were development of resistance to cefiderocol, clearance of bacteremia, adverse drug reactions, and hospital length of stay. Results Cefiderocol was dispensed in 22 unique patient encounters. It was most often used to treat respiratory tract (45.4%, 10/22) and cardiac device infections (40.9%, 9/22). Most infections were polymicrobial, however, the most common organisms isolated were Pseudomonas aeruginosa and Klebsiella pneumoniae. The clinical failure rate was 22.7% (5/22). One patient developed resistance to cefiderocol throughout the hospitalization. Eight patients were treated for bacteremia, and 87.5% (7/8) demonstrated microbiological cure. Minimal side effects were observed in this cohort; two patients developed diarrhea, and one of whom had confirmed C. difficile colitis. The median length of stay was 24 days. Conclusion This cohort of patients demonstrated that cefiderocol can be used in a variety of multidrug resistant infections including bacteremia. Although limited by a small sample size, this study demonstrated a low prevalence of resistance. These results are promising in the ongoing and emerging issue of antibiotic resistance, and larger studies are needed to determine true efficacy and place in therapy for cefiderocol. Disclosures All Authors: No reported disclosures." @default.
- W4311732330 created "2022-12-28" @default.
- W4311732330 creator A5002322606 @default.
- W4311732330 creator A5046218201 @default.
- W4311732330 creator A5065587585 @default.
- W4311732330 date "2022-12-01" @default.
- W4311732330 modified "2023-09-30" @default.
- W4311732330 title "1728. Real world experience with cefiderocol for multi drug resistant gram negative bacterial infection in a tertiary hospital" @default.
- W4311732330 doi "https://doi.org/10.1093/ofid/ofac492.1358" @default.
- W4311732330 hasPublicationYear "2022" @default.
- W4311732330 type Work @default.
- W4311732330 citedByCount "0" @default.
- W4311732330 crossrefType "journal-article" @default.
- W4311732330 hasAuthorship W4311732330A5002322606 @default.
- W4311732330 hasAuthorship W4311732330A5046218201 @default.
- W4311732330 hasAuthorship W4311732330A5065587585 @default.
- W4311732330 hasBestOaLocation W43117323301 @default.
- W4311732330 hasConcept C104317684 @default.
- W4311732330 hasConcept C114851261 @default.
- W4311732330 hasConcept C126322002 @default.
- W4311732330 hasConcept C177713679 @default.
- W4311732330 hasConcept C197934379 @default.
- W4311732330 hasConcept C2777058267 @default.
- W4311732330 hasConcept C2777637488 @default.
- W4311732330 hasConcept C2779443120 @default.
- W4311732330 hasConcept C2779802037 @default.
- W4311732330 hasConcept C501593827 @default.
- W4311732330 hasConcept C523546767 @default.
- W4311732330 hasConcept C54355233 @default.
- W4311732330 hasConcept C547475151 @default.
- W4311732330 hasConcept C55493867 @default.
- W4311732330 hasConcept C64778159 @default.
- W4311732330 hasConcept C71924100 @default.
- W4311732330 hasConcept C86803240 @default.
- W4311732330 hasConcept C89423630 @default.
- W4311732330 hasConcept C94665300 @default.
- W4311732330 hasConceptScore W4311732330C104317684 @default.
- W4311732330 hasConceptScore W4311732330C114851261 @default.
- W4311732330 hasConceptScore W4311732330C126322002 @default.
- W4311732330 hasConceptScore W4311732330C177713679 @default.
- W4311732330 hasConceptScore W4311732330C197934379 @default.
- W4311732330 hasConceptScore W4311732330C2777058267 @default.
- W4311732330 hasConceptScore W4311732330C2777637488 @default.
- W4311732330 hasConceptScore W4311732330C2779443120 @default.
- W4311732330 hasConceptScore W4311732330C2779802037 @default.
- W4311732330 hasConceptScore W4311732330C501593827 @default.
- W4311732330 hasConceptScore W4311732330C523546767 @default.
- W4311732330 hasConceptScore W4311732330C54355233 @default.
- W4311732330 hasConceptScore W4311732330C547475151 @default.
- W4311732330 hasConceptScore W4311732330C55493867 @default.
- W4311732330 hasConceptScore W4311732330C64778159 @default.
- W4311732330 hasConceptScore W4311732330C71924100 @default.
- W4311732330 hasConceptScore W4311732330C86803240 @default.
- W4311732330 hasConceptScore W4311732330C89423630 @default.
- W4311732330 hasConceptScore W4311732330C94665300 @default.
- W4311732330 hasIssue "Supplement_2" @default.
- W4311732330 hasLocation W43117323301 @default.
- W4311732330 hasOpenAccess W4311732330 @default.
- W4311732330 hasPrimaryLocation W43117323301 @default.
- W4311732330 hasRelatedWork W137943344 @default.
- W4311732330 hasRelatedWork W2201789966 @default.
- W4311732330 hasRelatedWork W2274212671 @default.
- W4311732330 hasRelatedWork W2358528625 @default.
- W4311732330 hasRelatedWork W2370252100 @default.
- W4311732330 hasRelatedWork W2761021459 @default.
- W4311732330 hasRelatedWork W2887469559 @default.
- W4311732330 hasRelatedWork W2891956809 @default.
- W4311732330 hasRelatedWork W3160359428 @default.
- W4311732330 hasRelatedWork W4284710444 @default.
- W4311732330 hasVolume "9" @default.
- W4311732330 isParatext "false" @default.
- W4311732330 isRetracted "false" @default.
- W4311732330 workType "article" @default.