FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311736093> ?p ?o ?g. }

• W4311736093 abstract "Abstract Background Mollicutes, such as Mycoplasma hominis and Ureaplasma spp, are fastidious bacteria that can cause invasive donor-derived infections in lung transplant recipients. Best practices for donor screening and recipient surveillance for Mollicute infections are unknown. This study assessed the performance of donor respiratory tract screening for Mollicutes. Methods We prospectively analyzed all lung transplant surgeries performed 10/5/20 – 9/25/21 at a single transplant center. Donor bronchoalveolar lavage (BAL) performed at time of procurement was tested for presence of urogenital Mycoplasmas and Ureaplasma spp. using culture and PCR. Treating clinicians were blinded to these results. Post-transplant recipient evaluation was performed at the discretion of the treating clinicians, who maintained a high index of suspicion for Mollicute infection. Mollicute cases were defined as recipients with any post-transplant culture or PCR that detected a Mollicute. We analyzed recipient outcomes and assessed the performance of donor BAL screening in predicting recipient Mollicute cases. Results In total, 115 patients underwent lung transplant. Of this cohort, 99 (86%) donors had adequate BAL samples for Mollicute testing via both culture and PCR. 8/99 (8%) donors had culture-positive samples, and 15/99 (15%) had PCR-positive samples for Mollicutes. Among the 99 corresponding recipients, 9 (9%) patients met the Mollicute case definition (Figure 1). These recipients were diagnosed a median of 6 days after transplant (IQR 4-15 days). 6 patients had pulmonary Mollicute detection alone, and 3 had invasive extrapulmonary thoracic infections. The only death was unrelated (Table 1). Donor BAL culture sensitivity was 6/9 (67%) in predicting recipient Mollicute cases, and sensitivity of PCR was 5/9 (56%). Positive predictive value (PPV) was 6/8 (75%) for donor culture and 5/15 (33%) for PCR (Table 2). Figure 1Clinical courses of 9 lung transplant recipients who acquired post-transplant Mycoplasma hominis or Ureaplasma species. Table 1 Characteristics of 9 lung transplant recipients who acquired post-transplant Mycoplasma hominis or Ureaplasma species. Table 2 Performance of donor bronchoalveolar lavage screening methods in predicting Mollicute acquisition among 99 lung transplant recipients. Conclusion In our single center cohort, donor BAL screening via culture predicted all serious recipient Mollicute infections and had better PPV than PCR. Given limitations of either screening method, clinicians should maintain a high index of suspicion for Mollicute infection after lung transplant to facilitate early diagnosis and effective treatment. Disclosures Barbara D. Alexander, MD, Astellas: Advisor/Consultant|HealthtrackRx: Advisor/Consultant|HealthtrackRx: Grant/Research Support|Scynexis: Grant/Research Support|UpToDate: Advisor/Consultant Arthur W. Baker, MD, MPH, Medincell: Advisor/Consultant." @default.
• W4311736093 created "2022-12-28" @default.
• W4311736093 creator A5007627227 @default.
• W4311736093 creator A5014276680 @default.
• W4311736093 creator A5026956475 @default.
• W4311736093 creator A5045088678 @default.
• W4311736093 creator A5046969325 @default.
• W4311736093 creator A5047423426 @default.
• W4311736093 creator A5060094040 @default.
• W4311736093 creator A5080865595 @default.
• W4311736093 date "2022-12-01" @default.
• W4311736093 modified "2023-09-23" @default.
• W4311736093 title "632. Donor-Derived Mollicute Infections in Lung Transplant Recipients: a Prospective Study of Donor Respiratory Tract Screening and Recipient Outcomes" @default.
• W4311736093 doi "https://doi.org/10.1093/ofid/ofac492.684" @default.
• W4311736093 hasPublicationYear "2022" @default.
• W4311736093 type Work @default.
• W4311736093 citedByCount "1" @default.
• W4311736093 countsByYear W43117360932023 @default.
• W4311736093 crossrefType "journal-article" @default.
• W4311736093 hasAuthorship W4311736093A5007627227 @default.
• W4311736093 hasAuthorship W4311736093A5014276680 @default.
• W4311736093 hasAuthorship W4311736093A5026956475 @default.
• W4311736093 hasAuthorship W4311736093A5045088678 @default.
• W4311736093 hasAuthorship W4311736093A5046969325 @default.
• W4311736093 hasAuthorship W4311736093A5047423426 @default.
• W4311736093 hasAuthorship W4311736093A5060094040 @default.
• W4311736093 hasAuthorship W4311736093A5080865595 @default.
• W4311736093 hasConcept C126322002 @default.
• W4311736093 hasConcept C141071460 @default.
• W4311736093 hasConcept C149453125 @default.
• W4311736093 hasConcept C188816634 @default.
• W4311736093 hasConcept C2775881110 @default.
• W4311736093 hasConcept C2777714996 @default.
• W4311736093 hasConcept C2777961210 @default.
• W4311736093 hasConcept C2778838687 @default.
• W4311736093 hasConcept C2781448352 @default.
• W4311736093 hasConcept C2909217659 @default.
• W4311736093 hasConcept C523546767 @default.
• W4311736093 hasConcept C54355233 @default.
• W4311736093 hasConcept C71924100 @default.
• W4311736093 hasConcept C86803240 @default.
• W4311736093 hasConcept C89423630 @default.
• W4311736093 hasConceptScore W4311736093C126322002 @default.
• W4311736093 hasConceptScore W4311736093C141071460 @default.
• W4311736093 hasConceptScore W4311736093C149453125 @default.
• W4311736093 hasConceptScore W4311736093C188816634 @default.
• W4311736093 hasConceptScore W4311736093C2775881110 @default.
• W4311736093 hasConceptScore W4311736093C2777714996 @default.
• W4311736093 hasConceptScore W4311736093C2777961210 @default.
• W4311736093 hasConceptScore W4311736093C2778838687 @default.
• W4311736093 hasConceptScore W4311736093C2781448352 @default.
• W4311736093 hasConceptScore W4311736093C2909217659 @default.
• W4311736093 hasConceptScore W4311736093C523546767 @default.
• W4311736093 hasConceptScore W4311736093C54355233 @default.
• W4311736093 hasConceptScore W4311736093C71924100 @default.
• W4311736093 hasConceptScore W4311736093C86803240 @default.
• W4311736093 hasConceptScore W4311736093C89423630 @default.
• W4311736093 hasIssue "Supplement_2" @default.
• W4311736093 hasLocation W43117360931 @default.
• W4311736093 hasOpenAccess W4311736093 @default.
• W4311736093 hasPrimaryLocation W43117360931 @default.
• W4311736093 hasRelatedWork W1983543579 @default.
• W4311736093 hasRelatedWork W2000191327 @default.
• W4311736093 hasRelatedWork W2010238913 @default.
• W4311736093 hasRelatedWork W2022735141 @default.
• W4311736093 hasRelatedWork W2031581417 @default.
• W4311736093 hasRelatedWork W2383408280 @default.
• W4311736093 hasRelatedWork W2391926937 @default.
• W4311736093 hasRelatedWork W2417439006 @default.
• W4311736093 hasRelatedWork W2594821081 @default.
• W4311736093 hasRelatedWork W3084297930 @default.
• W4311736093 hasVolume "9" @default.
• W4311736093 isParatext "false" @default.
• W4311736093 isRetracted "false" @default.
• W4311736093 workType "article" @default.