FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311748736> ?p ?o ?g. }

• W4311748736 abstract "Abstract Background Limited data exist on the long-term consequences of bloodstream infections (BSI). We examined incidence, 1-year mortality, and years of potential life lost (YPLL) following BSI by eight sentinel bacteria in adults. We also estimated the relative contribution of hospital-onset BSI (HO-BSI) and of antibiotic-resistant BSI to the burden of BSI. Methods We used data from Israel's national BSI surveillance system (covering E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, S. pneumoniae, S. aureus, E. faecalis and E. faecium, comprising 70% of all BSI) and the national death registry. Adults with BSI between 1/1/2018 and 31/12/2019 were included. The outcomes were all-cause 30-day and 1-year mortality. We constructed Kaplan-Meier curves and used the log-rank test to compare survival between age groups. We calculated the age-standardized mortality rate and YPLL using the Global Burden of Disease reference population and life expectancy tables. Results A total of 25,376 BSI occurred over 2 years in the adult Israeli population (mean adult population: 6,068,580). Drug-resistant BSI comprised 32% of all events (41.1% of HO-BSI). The annual BSI incidence was 209 per 100,000 population. The case fatality rate (CFR) was 25.6% at 30 days and 46.4% at 1 year. The 1-year CFR was higher among males than females (RR=1.17, 95% CI 1.14–1.20) and it increased with age (OR=1.37 per decade, 95% CI 1.36–1.39). In all age groups survival continued to decline up to 1 year (Figure). For the outcome of 1-year mortality, the annual age-standardized mortality rate and YPLL per 100,000 population following BSI were 48.6 and 1002.2, respectively. For comparison, the global mortality rate and YPLL from ischemic stroke are 36.6 and 521.8 per 100,000, respectively. HO-BSI represented 27.4% of BSI but contributed to 33.9% of deaths and 39.9% of YPLL. HO-BSI by drug-resistant bacteria represented 11.3% of BSI, 14.8% of deaths, and 17.4% of YPLL. Conclusion BSI have grave long-term consequences: nearly 50% of affected adult patients died within 1 year. The burden of BSI is higher than that of ischemic stroke. HO-BSI and drug-resistant BSI contribute disproportionately to BSI mortality and YPLL. Attention and resources should be directed to prevention of BSI, as well as to advances in early diagnosis and better treatment. Disclosures Yehuda Carmeli, MD, Allecra Therapeutics: Advisor/Consultant|MSD: Advisor/Consultant|Nabriva: Advisor/Consultant|Pfizer: Advisor/Consultant|Qpex Pharmaceuticals: Advisor/Consultant|Roche: Advisor/Consultant|Shinogi: Advisor/Consultant|Spero Therapeutics: Advisor/Consultant." @default.
• W4311748736 created "2022-12-28" @default.
• W4311748736 creator A5004373925 @default.
• W4311748736 creator A5023479710 @default.
• W4311748736 creator A5057532693 @default.
• W4311748736 creator A5060153696 @default.
• W4311748736 creator A5072201950 @default.
• W4311748736 creator A5081411031 @default.
• W4311748736 creator A5087323210 @default.
• W4311748736 creator A5087922206 @default.
• W4311748736 date "2022-12-01" @default.
• W4311748736 modified "2023-10-01" @default.
• W4311748736 title "739. The High Burden of Bloodstream Infection in Adults: A Nation-Wide Population- Based Study" @default.
• W4311748736 doi "https://doi.org/10.1093/ofid/ofac492.030" @default.
• W4311748736 hasPublicationYear "2022" @default.
• W4311748736 type Work @default.
• W4311748736 citedByCount "0" @default.
• W4311748736 crossrefType "journal-article" @default.
• W4311748736 hasAuthorship W4311748736A5004373925 @default.
• W4311748736 hasAuthorship W4311748736A5023479710 @default.
• W4311748736 hasAuthorship W4311748736A5057532693 @default.
• W4311748736 hasAuthorship W4311748736A5060153696 @default.
• W4311748736 hasAuthorship W4311748736A5072201950 @default.
• W4311748736 hasAuthorship W4311748736A5081411031 @default.
• W4311748736 hasAuthorship W4311748736A5087323210 @default.
• W4311748736 hasAuthorship W4311748736A5087922206 @default.
• W4311748736 hasBestOaLocation W43117487361 @default.
• W4311748736 hasConcept C120665830 @default.
• W4311748736 hasConcept C121332964 @default.
• W4311748736 hasConcept C126322002 @default.
• W4311748736 hasConcept C126451531 @default.
• W4311748736 hasConcept C133925201 @default.
• W4311748736 hasConcept C144024400 @default.
• W4311748736 hasConcept C149923435 @default.
• W4311748736 hasConcept C179755657 @default.
• W4311748736 hasConcept C187212893 @default.
• W4311748736 hasConcept C187316915 @default.
• W4311748736 hasConcept C2908647359 @default.
• W4311748736 hasConcept C61511704 @default.
• W4311748736 hasConcept C71924100 @default.
• W4311748736 hasConcept C99454951 @default.
• W4311748736 hasConceptScore W4311748736C120665830 @default.
• W4311748736 hasConceptScore W4311748736C121332964 @default.
• W4311748736 hasConceptScore W4311748736C126322002 @default.
• W4311748736 hasConceptScore W4311748736C126451531 @default.
• W4311748736 hasConceptScore W4311748736C133925201 @default.
• W4311748736 hasConceptScore W4311748736C144024400 @default.
• W4311748736 hasConceptScore W4311748736C149923435 @default.
• W4311748736 hasConceptScore W4311748736C179755657 @default.
• W4311748736 hasConceptScore W4311748736C187212893 @default.
• W4311748736 hasConceptScore W4311748736C187316915 @default.
• W4311748736 hasConceptScore W4311748736C2908647359 @default.
• W4311748736 hasConceptScore W4311748736C61511704 @default.
• W4311748736 hasConceptScore W4311748736C71924100 @default.
• W4311748736 hasConceptScore W4311748736C99454951 @default.
• W4311748736 hasIssue "Supplement_2" @default.
• W4311748736 hasLocation W43117487361 @default.
• W4311748736 hasLocation W43117487362 @default.
• W4311748736 hasOpenAccess W4311748736 @default.
• W4311748736 hasPrimaryLocation W43117487361 @default.
• W4311748736 hasRelatedWork W2001769621 @default.
• W4311748736 hasRelatedWork W2041342913 @default.
• W4311748736 hasRelatedWork W2067182892 @default.
• W4311748736 hasRelatedWork W2213541780 @default.
• W4311748736 hasRelatedWork W2280199486 @default.
• W4311748736 hasRelatedWork W2291139543 @default.
• W4311748736 hasRelatedWork W2615220822 @default.
• W4311748736 hasRelatedWork W3006272330 @default.
• W4311748736 hasRelatedWork W3166120058 @default.
• W4311748736 hasRelatedWork W4300753267 @default.
• W4311748736 hasVolume "9" @default.
• W4311748736 isParatext "false" @default.
• W4311748736 isRetracted "false" @default.
• W4311748736 workType "article" @default.