FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311750816> ?p ?o ?g. }

• W4311750816 abstract "Abstract Background Shortly after its introduction into clinical practice, Staphylococcus aureus isolates gained resistance to penicillin via the acquisition of β-lactamases. By the 1960s, these strains became the dominant staphylococci in clinical practice. However, a number of centers have recently described an increase in the proportion of methicillin susceptible S. aureus (MSSA) which are also susceptible to penicillin (PSSA). In our center we have recently observed the emergence of PSSA in osteoarticular infections. Little data are available regarding the prevalence or impact of PSSA in pediatric skin-and-soft-tissue infections (SSTI). Methods MSSA SSTI isolates were obtained through an ongoing surveillance study at Texas Children’s (TCH) from 1/2017-12/2021. Twenty community-acquired MSSA SSTI isolates were chosen at random from every six-month interval during the study period, for a total of 200 isolates to be screened. All isolates underwent PCR for blaZ β-lactamase, PVL genes and agr group. All blaZ negative isolates then underwent penicillin susceptibility testing using macrobroth dilution. Isolates which were blaZ negative and had a penicillin MIC ≤ 0.125 μg/ml were regarded as PSSA with the remainder regarded as penicillin-resistant MSSA (PR-MSSA). Results During the study period 1701 MSSA SSTI isolates were collected with 200 examined for penicillin susceptibility. The overall median age of subjects was 4.1 years (IQR: 1.6-10.4). PSSA accounted for 9% of isolates during the study period; the annual frequency of PSSA varied from 5-17.5%. PSSA and PR-MSSA cases were similar with respect to age, demographics, anatomic site of infection and rates of prior antibiotic exposure. Subjects with SSTI secondary to PSSA more often had a prior history of SSTI, a diagnosis of abscess and were more often admitted to the hospital (Figure). Among PSSA, 94.4% belonged to agrI and 33.3% were PVL positive. Penicillin-Susceptible S. aureus (PSSA) vs. Penicillin-Resistant Methicillin-Susceptible S. aureus (PR-MSSA) Pediatric SSTI Isolates Comparison of the clinical features of PSSA and PR-MSSA SSTI isolates. PSSA were significantly associated with the diagnosis of abscess as well as hospital admission. Conclusion PSSA account for a small but significant proportion of MSSA SSTI in children. Clinically distinguishing patients with PSSA and PR-MSSA is challenging. However, PSSA SSTI were associated with a greater rate of abscess formation and hospital admission, suggesting a high clinical impact of these infections. Further studies are needed to understand the optimal management of these infections. Disclosures Jonathon C. McNeil, MD, Agency for Healthcare Research and Quality: Grant/Research Support|Allergan: Provided reagents for unrelated research|Nabriva: Site investigator for multicenter clinical trial Kristina G. Hulten, PhD, Me-med: Grant/Research Support|Pfizer: Grant/Research Support Sheldon L. Kaplan, MD, MeMed: Grant/Research Support|Pfizer: Grant/Research Support." @default.
• W4311750816 created "2022-12-28" @default.
• W4311750816 creator A5002448964 @default.
• W4311750816 creator A5003315106 @default.
• W4311750816 creator A5007227069 @default.
• W4311750816 creator A5054604363 @default.
• W4311750816 creator A5066812140 @default.
• W4311750816 date "2022-12-01" @default.
• W4311750816 modified "2023-10-17" @default.
• W4311750816 title "1324. Penicillin-Susceptibility among <i>Staphylococcus aureus</i> Skin-and-Soft-Tissue Infections at a Children’s Hospital" @default.
• W4311750816 doi "https://doi.org/10.1093/ofid/ofac492.1154" @default.
• W4311750816 hasPublicationYear "2022" @default.
• W4311750816 type Work @default.
• W4311750816 citedByCount "0" @default.
• W4311750816 crossrefType "journal-article" @default.
• W4311750816 hasAuthorship W4311750816A5002448964 @default.
• W4311750816 hasAuthorship W4311750816A5003315106 @default.
• W4311750816 hasAuthorship W4311750816A5007227069 @default.
• W4311750816 hasAuthorship W4311750816A5054604363 @default.
• W4311750816 hasAuthorship W4311750816A5066812140 @default.
• W4311750816 hasBestOaLocation W43117508161 @default.
• W4311750816 hasConcept C174802600 @default.
• W4311750816 hasConcept C2779489039 @default.
• W4311750816 hasConcept C42972112 @default.
• W4311750816 hasConcept C501593827 @default.
• W4311750816 hasConcept C523546767 @default.
• W4311750816 hasConcept C54355233 @default.
• W4311750816 hasConcept C71924100 @default.
• W4311750816 hasConcept C86803240 @default.
• W4311750816 hasConcept C89423630 @default.
• W4311750816 hasConceptScore W4311750816C174802600 @default.
• W4311750816 hasConceptScore W4311750816C2779489039 @default.
• W4311750816 hasConceptScore W4311750816C42972112 @default.
• W4311750816 hasConceptScore W4311750816C501593827 @default.
• W4311750816 hasConceptScore W4311750816C523546767 @default.
• W4311750816 hasConceptScore W4311750816C54355233 @default.
• W4311750816 hasConceptScore W4311750816C71924100 @default.
• W4311750816 hasConceptScore W4311750816C86803240 @default.
• W4311750816 hasConceptScore W4311750816C89423630 @default.
• W4311750816 hasIssue "Supplement_2" @default.
• W4311750816 hasLocation W43117508161 @default.
• W4311750816 hasLocation W43117508162 @default.
• W4311750816 hasOpenAccess W4311750816 @default.
• W4311750816 hasPrimaryLocation W43117508161 @default.
• W4311750816 hasRelatedWork W1544844195 @default.
• W4311750816 hasRelatedWork W1958176239 @default.
• W4311750816 hasRelatedWork W1995243332 @default.
• W4311750816 hasRelatedWork W2023720562 @default.
• W4311750816 hasRelatedWork W2026176496 @default.
• W4311750816 hasRelatedWork W2122019629 @default.
• W4311750816 hasRelatedWork W2326830576 @default.
• W4311750816 hasRelatedWork W2346104741 @default.
• W4311750816 hasRelatedWork W2382345126 @default.
• W4311750816 hasRelatedWork W2412089778 @default.
• W4311750816 hasVolume "9" @default.
• W4311750816 isParatext "false" @default.
• W4311750816 isRetracted "false" @default.
• W4311750816 workType "article" @default.