FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311751457> ?p ?o ?g. }

• W4311751457 abstract "Abstract Background The incidence of carbapenem-resistant organisms (CROs) has increased over the past 3 decades. Carbapenem-resistance due to metallo-β-lactamases (MBLs) such as the Verona integron-encoded metallo-β-lactamase (VIM) are particularly problematic due to the limited treatment options. We describe a multi-species outbreak of VIM-producing CROs (VIM CROs) in a tertiary care hospital along with our experience using novel β-lactam antibiotics for treatment. Methods We performed a retrospective chart review after a cluster of patients in the burn unit of a tertiary care hospital were found to have infections with VIM CROs. Electronic medical records for all patients with a VIM CRO isolated between November 2021 and March 2022 were reviewed. Data regarding patient characteristics, antimicrobial use, culture results, antimicrobial susceptibility testing, and clinical outcomes were recorded for each patient. Results 8 patients were found to have VIM-mediated CRO burn wound infections, 5 of whom were also bacteremic with a VIM CRO. A VIM gene was identified in 5 different species (Pseudomonas aeruginosa and 4 Enterobacterales). None of the patients received carbapenems prior to isolation of a CRO. Among the 5 patients treated with cefiderocol, 2 had cefiderocol-resistant VIM CROs isolated 10-20 days after starting cefiderocol. 3 patients received the combination of ceftazidime/avibactam and aztreonam, and all had subsequent clearing of their CRO infection on follow-up cultures taken from the same site. Only one of the 8 patients died within 30 days of initial CRO isolation, after developing a subsequent fungal infection. The median Pitt bacteremia score at the time of initial CRO isolation was 1 (range 0-4) in the 7 patients who survived versus a score of 6 in the patient who died. Conclusion MBLs such as VIM have the potential for multi-species spread throughout hospital units even in the absence of carbapenem selection pressure. Although over 60% of the patients in this study had bacteremia and cefiderocol-resistance developed in 40% of the patients treated with cefiderocol, mortality was fortunately low in this group. While newer β-lactam antibiotics remain an exciting addition to our armamentarium, we must remain diligent in monitoring for rapid development of resistance. Disclosures Thomas R. Talbot, III, MD, MPH, OmniSolve: Board Member Romney Humphries, PhD, D(ABMM), M(ASCP), Accelerate: Advisor/Consultant|Accelerate: Stocks/Bonds|bioMerieux: Advisor/Consultant|IHMA: Advisor/Consultant|Pattern: Advisor/Consultant|Qiagen: Advisor/Consultant|QPex: Advisor/Consultant|Roche: Advisor/Consultant|Specific Diagnostics: Advisor/Consultant|Specific Diagnostics: Stocks/Bonds|ThermoFisher: Advisor/Consultant|Torus: Advisor/Consultant." @default.
• W4311751457 created "2022-12-28" @default.
• W4311751457 creator A5022932891 @default.
• W4311751457 creator A5028268383 @default.
• W4311751457 creator A5062111502 @default.
• W4311751457 creator A5074366699 @default.
• W4311751457 creator A5078065682 @default.
• W4311751457 date "2022-12-01" @default.
• W4311751457 modified "2023-10-14" @default.
• W4311751457 title "672. Report of a Multi-species Outbreak of VIM-producing Carbapenem-resistant Organisms in a Burn Unit and Subsequent Experience Using Novel β-lactam Antibiotics for Treatment" @default.
• W4311751457 doi "https://doi.org/10.1093/ofid/ofac492.724" @default.
• W4311751457 hasPublicationYear "2022" @default.
• W4311751457 type Work @default.
• W4311751457 citedByCount "0" @default.
• W4311751457 crossrefType "journal-article" @default.
• W4311751457 hasAuthorship W4311751457A5022932891 @default.
• W4311751457 hasAuthorship W4311751457A5028268383 @default.
• W4311751457 hasAuthorship W4311751457A5062111502 @default.
• W4311751457 hasAuthorship W4311751457A5074366699 @default.
• W4311751457 hasAuthorship W4311751457A5078065682 @default.
• W4311751457 hasBestOaLocation W43117514571 @default.
• W4311751457 hasConcept C116675565 @default.
• W4311751457 hasConcept C126322002 @default.
• W4311751457 hasConcept C159047783 @default.
• W4311751457 hasConcept C2775941552 @default.
• W4311751457 hasConcept C2776376669 @default.
• W4311751457 hasConcept C2776685102 @default.
• W4311751457 hasConcept C2776968632 @default.
• W4311751457 hasConcept C2777637488 @default.
• W4311751457 hasConcept C2779443120 @default.
• W4311751457 hasConcept C2779631663 @default.
• W4311751457 hasConcept C2780416669 @default.
• W4311751457 hasConcept C4937899 @default.
• W4311751457 hasConcept C501593827 @default.
• W4311751457 hasConcept C523546767 @default.
• W4311751457 hasConcept C54355233 @default.
• W4311751457 hasConcept C71924100 @default.
• W4311751457 hasConcept C86803240 @default.
• W4311751457 hasConcept C89423630 @default.
• W4311751457 hasConcept C94665300 @default.
• W4311751457 hasConceptScore W4311751457C116675565 @default.
• W4311751457 hasConceptScore W4311751457C126322002 @default.
• W4311751457 hasConceptScore W4311751457C159047783 @default.
• W4311751457 hasConceptScore W4311751457C2775941552 @default.
• W4311751457 hasConceptScore W4311751457C2776376669 @default.
• W4311751457 hasConceptScore W4311751457C2776685102 @default.
• W4311751457 hasConceptScore W4311751457C2776968632 @default.
• W4311751457 hasConceptScore W4311751457C2777637488 @default.
• W4311751457 hasConceptScore W4311751457C2779443120 @default.
• W4311751457 hasConceptScore W4311751457C2779631663 @default.
• W4311751457 hasConceptScore W4311751457C2780416669 @default.
• W4311751457 hasConceptScore W4311751457C4937899 @default.
• W4311751457 hasConceptScore W4311751457C501593827 @default.
• W4311751457 hasConceptScore W4311751457C523546767 @default.
• W4311751457 hasConceptScore W4311751457C54355233 @default.
• W4311751457 hasConceptScore W4311751457C71924100 @default.
• W4311751457 hasConceptScore W4311751457C86803240 @default.
• W4311751457 hasConceptScore W4311751457C89423630 @default.
• W4311751457 hasConceptScore W4311751457C94665300 @default.
• W4311751457 hasIssue "Supplement_2" @default.
• W4311751457 hasLocation W43117514571 @default.
• W4311751457 hasOpenAccess W4311751457 @default.
• W4311751457 hasPrimaryLocation W43117514571 @default.
• W4311751457 hasRelatedWork W1979120751 @default.
• W4311751457 hasRelatedWork W2077258216 @default.
• W4311751457 hasRelatedWork W2088118501 @default.
• W4311751457 hasRelatedWork W2091138882 @default.
• W4311751457 hasRelatedWork W2166164946 @default.
• W4311751457 hasRelatedWork W2169641796 @default.
• W4311751457 hasRelatedWork W2398314757 @default.
• W4311751457 hasRelatedWork W3137608310 @default.
• W4311751457 hasRelatedWork W4232680661 @default.
• W4311751457 hasRelatedWork W4367843616 @default.
• W4311751457 hasVolume "9" @default.
• W4311751457 isParatext "false" @default.
• W4311751457 isRetracted "false" @default.
• W4311751457 workType "article" @default.