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- W4311757961 endingPage "100517" @default.
- W4311757961 startingPage "100517" @default.
- W4311757961 abstract "Hypoxia is a prominent feature of malignant tumors and contributes to tumor proliferation, metastasis, and drug resistance in various solid tumors. Therefore, improving tumor oxygenation is crucial for curing tumors. To date, multiple strategies, including oxygen delivering and producing materials, have been designed to increase the oxygen concentration in hypoxic tumors. However, the unsustainable supply of oxygen is still the main obstacle, resulting in a suboptimal outcome in treating oxygen-deprived tumors. Thus, a sufficient oxygen supply is highly desirable in the treatment of hypoxic tumors. Photosynthesis, as the main source of oxygen in nature through the conversion of light energy into chemical energy and oxygen, has been widely studied in scientific research. Moreover, photosynthetic microorganisms have been increasingly applied in cancer therapy by increasing oxygenation, which improves the therapeutic effect of oxygen-consuming tumor therapeutic tools such as radiotherapy and photodynamic therapy. In this review, we summarize recent advances in the design and manufacture of live bacteria as oxygen shuttles for a new generation of hypoxic tumor treatment strategies. Finally, current challenges and future directions are also discussed for successfully addressing hypoxic tumor issues." @default.
- W4311757961 created "2022-12-28" @default.
- W4311757961 creator A5018271860 @default.
- W4311757961 creator A5050803462 @default.
- W4311757961 creator A5062328598 @default.
- W4311757961 creator A5063825401 @default.
- W4311757961 creator A5080370122 @default.
- W4311757961 date "2023-02-01" @default.
- W4311757961 modified "2023-09-30" @default.
- W4311757961 title "The development of live microorganism-based oxygen shuttles for enhanced hypoxic tumor therapy" @default.
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