Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311758691> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4311758691 abstract "Abstract Background A strong relationship links migraine with aura (MHA) and patent foramen ovale (PFO). Increased platelet aggregation and oxidative stress were documented in migraineurs. To date, no mechanisms connecting MHA to PFO have been demonstrated. Objectives To perform a comprehensive analysis of platelet activation, inflammation, and oxidative stress status in 78 aspirin-treated MHA-patients before (T0) and 6-months after (T1) PFO closure (LEARNER Study-NCT03521193-clinicaltrials.gov). The primary endpoint was migraine regression rate in relation to these parameters. Methods P-selectinpos-, activated-glycoprotein IIbIIIa (aGPIIbIIIa)pos-, Tissue Factor (TF)pos-, reactive oxygen species (ROS)pos-platelets, platelet-leukocyte aggregates (PLA) and microvesicles (MVs) were evaluated by flow cytometry; thrombin generation (TG) by Calibrated Automated Thrombogram (CAT) assay; oxidative stress status by mass spectrometry; serotonin and cytokines by ELISA. 12 aspirin-treated-healthy subjects (HS) were enrolled for comparison. Results Migraine resolution occurred in 69.7%, a significant reduction in 27%, while no effect was observed in 2 patients (3.2%). Only ROSpos-platelets, and TFpos-platelets and -MVs were significantly higher at T0, sustaining a TG capacity that was associated with an altered blood GSSG/GSH (Oxidized/Reduced Glutathione). This phenotype reverted to HS levels at T1. MHA-PFO plasma, added to HS blood, mirrored the in vivo platelet activation and N-acetylcysteine blunted it. GSSG in vitro reproduced the in vivo condition. Aspirin had little effect on the platelet prothrombotic phenotype which was effectively inhibited by a P2Y12-antagonist. Conclusion This study suggests a pathophysiological mechanism linking PFO, or its right-to-left shunt, with MHA. MHA-PFO patients show a platelet-associated prothrombotic phenotype, sustained by altered oxidative stress status. This phenotype, not fully controlled by aspirin but by P2Y12-antagonism, could play a primary role in producing the prodromal symptoms of migraine, and it is reverted after PFO closure together with a complete migraine remission" @default.
- W4311758691 created "2022-12-28" @default.
- W4311758691 creator A5004336111 @default.
- W4311758691 creator A5014774282 @default.
- W4311758691 creator A5031122376 @default.
- W4311758691 creator A5036797392 @default.
- W4311758691 creator A5041027663 @default.
- W4311758691 creator A5061203618 @default.
- W4311758691 creator A5080369703 @default.
- W4311758691 creator A5087838868 @default.
- W4311758691 creator A5088410801 @default.
- W4311758691 date "2022-12-14" @default.
- W4311758691 modified "2023-10-16" @default.
- W4311758691 title "823 MIGRAINE IN PFO PATIENTS: CHARACTERIZATION OF A PLATELET-ASSOCIATED PATHOPHYSIOLOGICAL MECHANISM BEFORE AND AFTER PFO CLOSURE: THE LEARNER STUDY" @default.
- W4311758691 doi "https://doi.org/10.1093/eurheartjsupp/suac121.377" @default.
- W4311758691 hasPublicationYear "2022" @default.
- W4311758691 type Work @default.
- W4311758691 citedByCount "0" @default.
- W4311758691 crossrefType "journal-article" @default.
- W4311758691 hasAuthorship W4311758691A5004336111 @default.
- W4311758691 hasAuthorship W4311758691A5014774282 @default.
- W4311758691 hasAuthorship W4311758691A5031122376 @default.
- W4311758691 hasAuthorship W4311758691A5036797392 @default.
- W4311758691 hasAuthorship W4311758691A5041027663 @default.
- W4311758691 hasAuthorship W4311758691A5061203618 @default.
- W4311758691 hasAuthorship W4311758691A5080369703 @default.
- W4311758691 hasAuthorship W4311758691A5087838868 @default.
- W4311758691 hasAuthorship W4311758691A5088410801 @default.
- W4311758691 hasBestOaLocation W43117586911 @default.
- W4311758691 hasConcept C126322002 @default.
- W4311758691 hasConcept C134018914 @default.
- W4311758691 hasConcept C181199279 @default.
- W4311758691 hasConcept C185592680 @default.
- W4311758691 hasConcept C2776151105 @default.
- W4311758691 hasConcept C2777628954 @default.
- W4311758691 hasConcept C3018697912 @default.
- W4311758691 hasConcept C538909803 @default.
- W4311758691 hasConcept C55493867 @default.
- W4311758691 hasConcept C71924100 @default.
- W4311758691 hasConcept C89560881 @default.
- W4311758691 hasConcept C98274493 @default.
- W4311758691 hasConceptScore W4311758691C126322002 @default.
- W4311758691 hasConceptScore W4311758691C134018914 @default.
- W4311758691 hasConceptScore W4311758691C181199279 @default.
- W4311758691 hasConceptScore W4311758691C185592680 @default.
- W4311758691 hasConceptScore W4311758691C2776151105 @default.
- W4311758691 hasConceptScore W4311758691C2777628954 @default.
- W4311758691 hasConceptScore W4311758691C3018697912 @default.
- W4311758691 hasConceptScore W4311758691C538909803 @default.
- W4311758691 hasConceptScore W4311758691C55493867 @default.
- W4311758691 hasConceptScore W4311758691C71924100 @default.
- W4311758691 hasConceptScore W4311758691C89560881 @default.
- W4311758691 hasConceptScore W4311758691C98274493 @default.
- W4311758691 hasIssue "Supplement_K" @default.
- W4311758691 hasLocation W43117586911 @default.
- W4311758691 hasOpenAccess W4311758691 @default.
- W4311758691 hasPrimaryLocation W43117586911 @default.
- W4311758691 hasRelatedWork W1574451752 @default.
- W4311758691 hasRelatedWork W1989929097 @default.
- W4311758691 hasRelatedWork W2030293857 @default.
- W4311758691 hasRelatedWork W2081403995 @default.
- W4311758691 hasRelatedWork W2120301728 @default.
- W4311758691 hasRelatedWork W2185627097 @default.
- W4311758691 hasRelatedWork W2365634061 @default.
- W4311758691 hasRelatedWork W2388768538 @default.
- W4311758691 hasRelatedWork W2419082276 @default.
- W4311758691 hasRelatedWork W4380354184 @default.
- W4311758691 hasVolume "24" @default.
- W4311758691 isParatext "false" @default.
- W4311758691 isRetracted "false" @default.
- W4311758691 workType "article" @default.