Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311761025> ?p ?o ?g. }
- W4311761025 endingPage "104060" @default.
- W4311761025 startingPage "104060" @default.
- W4311761025 abstract "Magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) imaging are combined to diagnose cancer with high physiological, anatomical, and metabolism sensitivity. For targeting hepatoma carcinoma, a drug delivery system is employed to carry drugs or chemicals to a specific area. Galactose is one of the sugar molecules which can be bound and increase uptake with asialoglycoprotein receptor (ASGP-R). In this study, superparamagnetic iron oxide nanoparticles (SPIONs), Galactose-functionalized poly(ethylene glycol)-block-poly(lactic acid) (Gal-PEG-b-PLA) and Diethylenetriaminepentaacetic acid-functionalized poly(ethylene glycol)-block-poly(lactic acid) (DTPA-PEG-b-PLA) were successfully synthesized and constructed to DTPA/Gal/SPIO micelles (targeting micelles) and DTPA/Met/SPIO micelles (non-targeting micelles). Technetium-99 m (99mTc) formed a complex with DTPA on the micelles as 99mTc/Gal/SPIO micelles by using stannous chloride and the pH was adjusted to acidic condition. The sizes of DTPA/Gal/SPIO micelles and DTPA/Met/SPIO micelles were lower than 100 nm with a spherical shape. In vitro study with HepG2-and L929-incubated micelles showed the intensity of blue staining of Prussian blue related to the amount of SPIO. 99mTc/Gal/SPIO micelles incubated with HepG2 exhibited signal intensity (SPECT signal) and relative R2* (MRI signal) higher than 99mTc/Met/SPIO micelles at the same time. According to these results, 99mTc-labeled Galactose-functionalized SPIO micelles have the potential for specific targeting to HepG2 and can aid in the diagnosis of cancer with MRI and SPECT dual imaging." @default.
- W4311761025 created "2022-12-28" @default.
- W4311761025 creator A5000750833 @default.
- W4311761025 creator A5004510048 @default.
- W4311761025 creator A5012964554 @default.
- W4311761025 creator A5013434423 @default.
- W4311761025 creator A5018058817 @default.
- W4311761025 creator A5029018299 @default.
- W4311761025 creator A5041076779 @default.
- W4311761025 creator A5044550703 @default.
- W4311761025 creator A5059245526 @default.
- W4311761025 creator A5065988116 @default.
- W4311761025 creator A5066766358 @default.
- W4311761025 creator A5074512771 @default.
- W4311761025 date "2023-01-01" @default.
- W4311761025 modified "2023-09-27" @default.
- W4311761025 title "99mTc /SPIO-loaded polymeric micelles as MRI and SPECT imaging, cancer-targeted nanoprobe for liver cancer detection" @default.
- W4311761025 cites W1490508708 @default.
- W4311761025 cites W1531388150 @default.
- W4311761025 cites W1967260930 @default.
- W4311761025 cites W1984677400 @default.
- W4311761025 cites W1987747996 @default.
- W4311761025 cites W2023740230 @default.
- W4311761025 cites W2026136306 @default.
- W4311761025 cites W2027463801 @default.
- W4311761025 cites W2039985275 @default.
- W4311761025 cites W2048042220 @default.
- W4311761025 cites W2052108548 @default.
- W4311761025 cites W2103637700 @default.
- W4311761025 cites W2110721051 @default.
- W4311761025 cites W2253433356 @default.
- W4311761025 cites W2276061839 @default.
- W4311761025 cites W2305819920 @default.
- W4311761025 cites W2318656065 @default.
- W4311761025 cites W2363475390 @default.
- W4311761025 cites W2577652288 @default.
- W4311761025 cites W2588746623 @default.
- W4311761025 cites W2592163316 @default.
- W4311761025 cites W2761432332 @default.
- W4311761025 cites W2795017962 @default.
- W4311761025 cites W2808741207 @default.
- W4311761025 cites W2884712395 @default.
- W4311761025 cites W2901449182 @default.
- W4311761025 cites W2902512219 @default.
- W4311761025 cites W2907118622 @default.
- W4311761025 cites W2910344375 @default.
- W4311761025 cites W2910486488 @default.
- W4311761025 cites W2911610925 @default.
- W4311761025 cites W2967205362 @default.
- W4311761025 cites W2975426185 @default.
- W4311761025 cites W2976790463 @default.
- W4311761025 cites W3016685804 @default.
- W4311761025 cites W3045740727 @default.
- W4311761025 cites W3108941575 @default.
- W4311761025 cites W3109956221 @default.
- W4311761025 cites W3115205079 @default.
- W4311761025 cites W3128794480 @default.
- W4311761025 cites W4205719528 @default.
- W4311761025 cites W4226031390 @default.
- W4311761025 cites W4249150730 @default.
- W4311761025 doi "https://doi.org/10.1016/j.jddst.2022.104060" @default.
- W4311761025 hasPublicationYear "2023" @default.
- W4311761025 type Work @default.
- W4311761025 citedByCount "0" @default.
- W4311761025 crossrefType "journal-article" @default.
- W4311761025 hasAuthorship W4311761025A5000750833 @default.
- W4311761025 hasAuthorship W4311761025A5004510048 @default.
- W4311761025 hasAuthorship W4311761025A5012964554 @default.
- W4311761025 hasAuthorship W4311761025A5013434423 @default.
- W4311761025 hasAuthorship W4311761025A5018058817 @default.
- W4311761025 hasAuthorship W4311761025A5029018299 @default.
- W4311761025 hasAuthorship W4311761025A5041076779 @default.
- W4311761025 hasAuthorship W4311761025A5044550703 @default.
- W4311761025 hasAuthorship W4311761025A5059245526 @default.
- W4311761025 hasAuthorship W4311761025A5065988116 @default.
- W4311761025 hasAuthorship W4311761025A5066766358 @default.
- W4311761025 hasAuthorship W4311761025A5074512771 @default.
- W4311761025 hasConcept C11268172 @default.
- W4311761025 hasConcept C155672457 @default.
- W4311761025 hasConcept C16387964 @default.
- W4311761025 hasConcept C171250308 @default.
- W4311761025 hasConcept C178790620 @default.
- W4311761025 hasConcept C184651966 @default.
- W4311761025 hasConcept C185592680 @default.
- W4311761025 hasConcept C192562407 @default.
- W4311761025 hasConcept C2777516009 @default.
- W4311761025 hasConcept C2984398910 @default.
- W4311761025 hasConcept C2989005 @default.
- W4311761025 hasConcept C71924100 @default.
- W4311761025 hasConceptScore W4311761025C11268172 @default.
- W4311761025 hasConceptScore W4311761025C155672457 @default.
- W4311761025 hasConceptScore W4311761025C16387964 @default.
- W4311761025 hasConceptScore W4311761025C171250308 @default.
- W4311761025 hasConceptScore W4311761025C178790620 @default.
- W4311761025 hasConceptScore W4311761025C184651966 @default.
- W4311761025 hasConceptScore W4311761025C185592680 @default.
- W4311761025 hasConceptScore W4311761025C192562407 @default.
- W4311761025 hasConceptScore W4311761025C2777516009 @default.