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• W4311761391 endingPage "175439" @default.
• W4311761391 startingPage "175439" @default.
• W4311761391 abstract "Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Limited options are available for the treatment of age-related, multiple pathogenic mechanism-contributed diseases that usually advance to irreversible conditions with severe neurological deficits and result in a heavy socioeconomic burden on patients, families, and society. A therapy that decelerates disease progression and reduces the socioeconomic burden stemming from these diseases is required. Glucagon-like peptide-1 receptor (GLP-1R) is an important class of medication for type 2 diabetes mellitus (T2DM). Through pancreatic effects, GLP-1R agonists can stimulate insulin secretion, increase β-cell proliferation, reduce β-cell apoptosis, and inhibit glucagon secretion in patients with T2DM. Currently, seven clinically approved GLP-1R agonists are used for T2DM: exenatide, liraglutide, lixisenatide, extended-release exenatide, albiglutide, dulaglutide, and semaglutide. Besides the pancreas, GLP-1Rs are also expressed in organs, such as the gastrointestinal tract, heart, lung, kidney, and brain, indicating their potential use in diseases other than T2DM. Emerging evidence reveals that GLP-1R agonists possess pleiotropic effects that enrich neurogenesis, diminish apoptosis, preclude neurons from oxidative stress, and reduce neuroinflammation in various neurological conditions. These favorable effects may also be employed in neurodegenerative diseases. Herein, we reviewed the recent progress, both in preclinical studies and clinical trials, regarding these clinically used GLP-1R agonists in aging-related neurodegenerative diseases, mainly AD and PD. We stress the pleiotropic characteristics of GLP-1R agonists as repurposing drugs to target multiple pathological mechanisms and for use in the future for these devastating neurodegenerative conditions." @default.
• W4311761391 created "2022-12-28" @default.
• W4311761391 creator A5010349545 @default.
• W4311761391 creator A5057584898 @default.
• W4311761391 creator A5068365096 @default.
• W4311761391 creator A5083315383 @default.
• W4311761391 date "2023-01-01" @default.
• W4311761391 modified "2023-10-14" @default.
• W4311761391 title "Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases" @default.
• W4311761391 cites W1498746154 @default.
• W4311761391 cites W1539187429 @default.
• W4311761391 cites W1549622883 @default.
• W4311761391 cites W1578038979 @default.
• W4311761391 cites W1596575266 @default.
• W4311761391 cites W1752193530 @default.
• W4311761391 cites W1840775077 @default.
• W4311761391 cites W1890054393 @default.
• W4311761391 cites W1918985013 @default.
• W4311761391 cites W1966214201 @default.
• W4311761391 cites W1979288606 @default.
• W4311761391 cites W1982795519 @default.
• W4311761391 cites W1985305554 @default.
• W4311761391 cites W1998882505 @default.
• W4311761391 cites W2007265598 @default.
• W4311761391 cites W2010034085 @default.
• W4311761391 cites W2013794398 @default.
• W4311761391 cites W2022847635 @default.
• W4311761391 cites W2030270894 @default.
• W4311761391 cites W2034930763 @default.
• W4311761391 cites W2037834336 @default.
• W4311761391 cites W2056578191 @default.
• W4311761391 cites W2059140614 @default.
• W4311761391 cites W2060170946 @default.
• W4311761391 cites W2065222310 @default.
• W4311761391 cites W2065372294 @default.
• W4311761391 cites W2069515205 @default.
• W4311761391 cites W2077445047 @default.
• W4311761391 cites W2078613171 @default.
• W4311761391 cites W2080785707 @default.
• W4311761391 cites W2085568322 @default.
• W4311761391 cites W2087787276 @default.
• W4311761391 cites W2106339546 @default.
• W4311761391 cites W2107387649 @default.
• W4311761391 cites W2118428015 @default.
• W4311761391 cites W2123319002 @default.
• W4311761391 cites W2124852816 @default.
• W4311761391 cites W2126525177 @default.
• W4311761391 cites W2129085204 @default.
• W4311761391 cites W2138677261 @default.
• W4311761391 cites W2147734798 @default.
• W4311761391 cites W2150472993 @default.
• W4311761391 cites W2154236525 @default.
• W4311761391 cites W2159205789 @default.
• W4311761391 cites W2159271495 @default.
• W4311761391 cites W2161457840 @default.
• W4311761391 cites W2164948885 @default.
• W4311761391 cites W2195120335 @default.
• W4311761391 cites W2211963426 @default.
• W4311761391 cites W2270971263 @default.
• W4311761391 cites W2292755321 @default.
• W4311761391 cites W231967990 @default.
• W4311761391 cites W2342553225 @default.
• W4311761391 cites W2344081812 @default.
• W4311761391 cites W2346080909 @default.
• W4311761391 cites W2395478387 @default.
• W4311761391 cites W2477594648 @default.
• W4311761391 cites W2513875819 @default.
• W4311761391 cites W2520005058 @default.
• W4311761391 cites W2563087870 @default.
• W4311761391 cites W2566099971 @default.
• W4311761391 cites W2570634615 @default.
• W4311761391 cites W2593866083 @default.
• W4311761391 cites W2595891670 @default.
• W4311761391 cites W2599792256 @default.
• W4311761391 cites W2609107212 @default.
• W4311761391 cites W2609885671 @default.
• W4311761391 cites W2613708921 @default.
• W4311761391 cites W2735873011 @default.
• W4311761391 cites W2744843428 @default.
• W4311761391 cites W2746649910 @default.
• W4311761391 cites W2756066122 @default.
• W4311761391 cites W2769441697 @default.
• W4311761391 cites W2772871657 @default.
• W4311761391 cites W2781793537 @default.
• W4311761391 cites W2793413710 @default.
• W4311761391 cites W2798054687 @default.
• W4311761391 cites W2808505023 @default.
• W4311761391 cites W2884234047 @default.
• W4311761391 cites W2887342138 @default.
• W4311761391 cites W2887818584 @default.
• W4311761391 cites W2888880555 @default.
• W4311761391 cites W2900848270 @default.
• W4311761391 cites W2903677519 @default.
• W4311761391 cites W2908881986 @default.
• W4311761391 cites W2909897769 @default.
• W4311761391 cites W2911194495 @default.
• W4311761391 cites W2913950552 @default.
• W4311761391 cites W2919649186 @default.

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